Chen, Chuan-Mu[ Professor ]

Molecular Embryology & DNA Methylation Lab.
Office Tel: (04)22840319 # 701、(04)22856309
Lab. Tel: (04) 22840319 # 702
Fax: (04) 22874740
Location: Life Science, Room 701
Highest Education: PhD, National Taiwan University
Professional Specialty: Molecular Embryology; Embryonic Stem Cells; Transgenic Cloned Animals; Epigenetic Study, Cancer Biology 
E-mail: chchen1@dragon.nchu.edu.tw
Lab. WebSite:  
 
Year Title
2014.02 The 2014 MOST Outstanding Research Award
2013.12 The 2013 MOST Agricultural Biotechnology Industrialization Award
2012.10 The 2012 Taipei International Invention Award for technology trade
2012.09 The 9th National Invention and Creation Award, MEA
2011.10 The 18th TECO Award in Biomedical Science
2011.08 The Scientific Award of Excellence 2011 on Animal Biotechnology, USA
2011.02 The 3rd Taiwn National Innovation Award
2010.09 The 7th National Invention and Creation Awars, MEA
2010.07 The 4th Far Eastern Y. Z. Hsu Science and Technology Award
2006.09 The 44th ROC Ten Outstanding Young People Award
2006.02 The 2nd Taiwan President Agricultural Award
 
Graduate from Major in Degree Period
National Taiwan University Genetic Engineering, Institute of Animal Science Ph.D. 1991/09 - 1995/05
National Taiwan University Department of Animal Science Bachelor 1987/09 - 1991/06
 
Organization Department Title Period
National Chung Hsing University College of Life Sciences Dean 2016/08 - Now
Edinburgh University, UK Molecular and Clinical Medicine College Visiting Professor 2004/06 - 2004/07
Missuori University, Medical College, USA Microarray Center Visiting Professor 2001/03 - 2001/08
Ellis Fischel Cancer Center Missuori, MO, USA Researcher 2001/09 - 2002/03
National Quemoy University Biotechnology Chair Professor 2015/08 - Now
National Chung Hsing University Office of Research and Development Dean 2009/08 - 2016/01
National Chung Hsing University Ph.D. Program in Medical Biotechnology Distinguished Professor 2013/08 - Now
National Chung Hsing University Department of Life Sciences Honorary Distinguished Professor 2013/08 - Now
National Chung Hsing University Department of Life Sciences Distinguished Professor 2007/08 - Now
NCHU-Academia Sinica PhD. Program in Microbial Genomics Distinguished Professor 2010/08 - Now
Academia Sinica-NCHU Ph.D. Program in Mol. Biol. Agricul. Sci. (TIGP) Distinguished Professor 2007/08 - Now
NCHU - NHRI PhD. Program in Tissue Eng. Regen. Med. Distinguished Professor 2010/08 - Now
School of Medicine, National Yang Ming University Institute of Clinical Medicine Adjunct Professor 2007/08 - 2009/07
National Chung Hsing University Department of Life Sciences Professor & Director 2005/08 - 2009/07
National Chung Hsing University Biotechnology Center Professor & Division Director 2004/08 - 2008/07
National Chung Hsing University Department of Life Sciences Associate Professor 2002/08 - 2004/08
National Chung Hsing University Department of Zoology Associate Professor 2000/08 - 2002/08
National Chung Hsing University Department of Zoology Assistant Professor 1998/02 - 2000/07
National Chung Hsing University Department of Zoology Lecturer 1996/08 - 1998/01
National Taiwan University Molecular Reproduction Lab Postdoc fellow 1995/08 - 1996/07
 
 
Term Course Credit Class
下學期 動物基因轉殖技術學 2學分(選修) 博碩士班
下學期 遺傳學(正課+實驗) 4學分(必修) 生科系二年級
下學期 生物技術學(正課+實習) 3學分(選修) 生科系三年級
下學期 生命科學與工程 2學分(選修) 通識講座(材料系)
下學期 分子胚胎專題研究(二) 2學分(選修) 博碩士班
下學期 生物科技學特論 2學分(必修) 博士班
上學期 生物科技產程 2學分(選修) 生科系四年級
上學期 遺傳學實驗課 1學分(必修) 昆蟲系三年級
上學期 胚胎學 3學分(選修) 生科系三年級
上學期 生命科學與工程 3學分(選修) 通識講座(化工系)
上學期 生技產業暑期校外實習 1學分(選修) 博碩士班
上學期 分子生物學 4學分(必修) 生科系三年級
上學期 分子胚胎學專題研究(一) 2學分(選修) 博碩士班
 
A.期刊論文
 
1.Y. A. Tsou, Y. T. Tung, H. C. Chen, T. F. Wu, C. C. Lin, C. H. Lai, H. L. Chen, and C. M. Chen*. 2016/10 Lactoferrin interacts with SPLUNC1 to attenuate lipopolysaccharide-induced inflammation of human nasal epithelial cells via down-regulated MEK1/2-MAPK signaling.,Biochem. Cell Biol. (Accepted 2016, Oct. 16). (SCI)
 
2.C. W. Lai, H. L. Chen, T. C. Tsai, T. W. Chu, S. H. Yang, K. Y. Chong, and C. M. Chen*. 2016/08 Sexually dimorphic expression of eGFP transgene in the Akr1A1 locus of mouse liver regulated by sex hormone-related epigenetic remodeling.,Scientific Reports, 6: e24023. (SCI) [IF=5.578; Multidisciplinary Sciences, 5/57 = Top 8.7%] [Nature系列期刊]. (SCI)
 
3.P. H. Cheng, Y. F. Chang, S. H. Mao, H. L. Lin, C. M. Chen, and S. H. Yang*. 2016/08 Lentiviral transgenesis in mice via a simple method of viral concentration.,Theriogenology 86(6): 1427-1435.. (SCI)
 
4.Y. W. Lan, S. M. Theng, T. T. Huang, K. B. Choo, C. M. Chen, H. P. Kuo, and K. Y. Chong*. 2016/08 Oncostatin M-preconditioned mesenchymal stem cells alleviate bleomycin-induced pulmonary fibrosis through paracrine effects of the hepatocyte growth factor.,Stem Cells Translat. Med. (Accepted 2016, Aug. 29) [IF=4.247; Cell & Tissue Engineering, 6/21= 28.5%] . (SCI)
 
5.C. W. Lai, H. L. Chen, C. C. Yen, J. L. Wang, S. H. Yang, and C. M. Chen*. 2016/06 Using dual-fluorescence reporting genes to establish an in vivo imaging model of orthotopic lung adenocarcinoma in mice.,Mol. Imaging Biol. 2016 May 19. [Epub ahead of print]. (SCI)
 
6.W. J. Lo, W. S. Chang, H. F. Hsu, H. X. Ji, C. L. Hsiao, C. W. Tsai, S. P. Yeh, C. M. Chen* and D. T. Bau*. 2016/05 Significant association of interleukin-10 polymorphisms with childhood leukemia susceptibility in Taiwan.,In Vivo 30(3): 265-269. . (SCI)
 
7.S. W. Tsai, H. L. Chen, Y. T. Tung, S. H. Yang, C. Y. Liu, M. Lu, H. J. Pai, C. C. Lin, and C. M. Chen*. 2016/01 Myostatin propeptide gene delivery by gene gun ameliorates muscle atrophy in a rat model of botulinum toxin-induced nerve denervation.,Life Sci. 146: 15-23. (SCI) . (SCI)
 
8.H. L. Chen, T. C. Tsai, Y. C. Tsai, J. W. Liao, C. C. Yen, and C. M. Chen*. 2016 Kefir peptides prevent high-fructose corn syrup-induced non-alcoholic fatty liver disease in a murine model by modulation of inflammation and the JAK2 signaling pathway.,Nutrition & Diabetes Accepted Oct. 27, 2016. [Nature系列期刊]. (SCI)
 
9.Y. A. Tsou, C. C. Lin, C. J. Tai, M. H. Tsai, C. M. Chen*, and C. H. Lai*. 2015/12 Interleukin-13 inhibits lipopolysaccharide-induced BPIFA1 expression in nasal epithelial cells. ,PLoS ONE 10(12): e0143484.. (SCI)
 
10.M. Y. Tu, H. L. Chen, Y. T. Tung, T. C. Tsai, S. Y. Chang, C. H. Chuang, and C. M. Chen*. 2015/12 Short-term effects of kefir-fermented milk consumption on bone mineral density and bone metabolism in a randomized clinical trial of osteoporotic patients.,PLoS ONE, 10(12):e0144231. (SCI) [IF=4.092; Biology, 12/84 = Top 14.3%]. (SCI)
 
11.Y. L. Lin, H. L. Chen, S. B. Cheng, D. C. Yeh, C. C. Huang, F. K. P’eng, T. C. Tsai, C. C. Wu and C. M. Chen*. 2015/11 Methylation-silencing RCC1 expression is associated with tumorigenesis and depth of invasion in gastric cancer.,Int. J. Clin. Pathol. 8(11):14257-14269. (SCI) . (SCI)
 
12.M. H. Fu, C. L. Li, H. L. Lin, S. J. Tsai, Y. Y. Lai, Y. F. Chang, P. H. Cheng, C. M. Chen, and S. H. Yang*. 2015/09 The potential regulatory mechanisms of miR-196a in Huntington's disease through bioinformatic analyses.,PLoS ONE 10(9): e0137637.. (SCI)
 
13.W. Chen, Y. Y. Chen, C. F. Tsai, S. C. C. Chen, M. S. Lin, L. B. Ware, and C. M. Chen*. 2015/09 Incidence and outcomes of acute respiratory distress syndrome–A nationwide registry based study in Taiwan, 1997-2011.,Medicine, 94(43): e1849. [IF=5.723; Medicine, General & Internal, 15/153= Top 9.8%]. (SCI)
 
14.C. Y. Liu, M. L. Lee, C. S. Yang, C. M. Chen, M. Y. Min, and H.W. Yang*. 2015/08 Morphological and physiological evidence of a synaptic connection between the lateral parabrachial nucleus and neurons in the A7 catecholamine cell group in rats.,J. Biomed. Sci., 22(1): 79.. (SCI)
 
15.Y. W. Lan, K. B. Choo, C. M. Chen, T. H. Hung, Y. B. Chen, C. H. Hsieh, H. P. Kuo, and K. Y. Chong*. 2015/06 Hypoxia-preconditioned mesenchymal stem cells attenuates bleomycin-induced pulmonary fibrosis.,Stem Cell Res. Ther. 6(1): 97. (SCI) [IF=4.634; Medicine, Research & Experimental, 19/124= Top 15.3%] (Highly Access Paper: 2063 times) [Cell Ressearch & Therapy 6:130, 2015特別報導; 07/14/2015]). (SCI)
 
16.C. W. Kuo, C. J. Shen, Y. T. Tung, H. L. Chen, Y. H. Chen, W. H. Chang, K. C. Cheng, S. H. Yang, and C. M. Chen*. 2015/06 Extracellular superoxide dismutase ameliorates streptozotocin-induced diabetic nephropathy via inhibiting the ROS/ERK1/2 signaling.,Life Sci. 135: 77-86. (SCI). (SCI)
 
17.Y. A. Tsou, C. D. Lin, H. H. Hsu, M. T. Peng, Y. K. Kuo, N. Tien, J. P. Li, C. K. Wang, H. S. Wu, M. H. Tsai, C. M. Chen* and C. H. Lai. 2015/06 Association of beta-lactam-sensitive Haemophilus influenzae type B with adenoid biofilm formation in patients with adenoidectomy surgery.,Surg. Infect. 16(6): 709-715. (SCI) [Feature Articles 特別報導; 12/08-22/2015]. (SCI)
 
18.Y. T. Tung, P. W. Huang, Y. C. Chou, C. W. Lai, H. P. Wang, H. C. Ho, C. C. Yen, C. Y. Tu, D. C. Yeh, J. L. Wang, K. Y. Chong, and C. M. Chen* 2015/05 Lung tumorigenesis induced by human vascular endothelial growth factor (hVEGF)-A165 overexpression in transgenic mice and amelioration of tumor formation by miR-16.,Oncotarget. 6(12): 10222-10238. [IF=6.627; Oncology, 17/203= Top 8.4%]. (SCI)
 
19.T. C. Tsai, Y. T. Tung, Y. H. Kuo, J. W. Liao, H. C. Tsai, K. Y. Chong, H. L. Chen, and C. M. Chen* 2015/02 Anti-inflammatory effects of Antrodia camphorata, an herbal medicine, in a mouse skin ischemia model.,J. Ethnopharmacol. 159: 113-121. (SCI)
 
20.K. Y. Chong, C. J. Hsu, T. H. Hung, H. S. Hu, T. H. Wang, C. H. Wang, C. M. Chen, K. B. Choo, H. C. Lai, and C. P. Tseng. 2015/01 Wnt pathway activation and ABCB1 expression account for attenuation of proteasome inhibitor-mediated apoptosis in multidrug-resistant cancer cells.,Cancer Biol Ther. 16 (1): 149-159. [IF=3.630, Oncology, 65/202=32%]. (SCI)
 
21.H. C. Liu, M. C. Lu, Y. C. Lin, Y. C. Lai, M. S. Jan, W. L. Lin, and C. M. Chen* 2015/01 Aortic graft infection caused by invasive pulmonary aspergillosis. ,Surg. Infect. 16(1): 112-113.. (SCI)
 
22.H. C. Liu, H. L. Chen, and C.M. Chen*. 2015/01 House dust mite allergy and associated allergen-specific immunotherapy in allergic asthma.,Immunome Res. 11: 085. (SCI) [Unofficial IF*=19.87; Immunology]. (SCI)
 
23.H. L. Chen, Y. T. Tung, C. H. Chuang, M. Y. Tu, T. C. Tsai, S. Y. Chang, and C. M. Chen* 2015/01 Kefir improves bone mass and microarchitecture in an ovariectomized rat model of postmenopausal osteoporosis.,Osteoporosis Int. 26: 589-599. [IF=4.165; Endocrinology & Metabolism, 30/124= Top 24%] [World BioMed Frontiers 特別報導; 09/28/2015]. (SCI)
 
24.Y. W. Lan, K. B. Choo, C. M. Chen, T. H. Hung, C. H. Hsieh, H. P. Kuo, and K. Y. Chong* 2014/12 Wnt5A regulates ABCB1 expression in multidrug-resistant cancer cells through activation of the non-canonical PKA/β-catenin pathway.,Oncotarget. 5 (23): 12273-12290. [IF=6.627; Oncology, 17/203= Top 8.4%]. (SCI)
 
25.H. C. Liu, M. C. Lu, Y. C. Lin, T. C. Wu, J. Y. Hsu, M. S. Jan, and C. M. Chen* 2014/12 Differences in IL-8 in serum and exhaled breath condensate from patients with exacerbated COPD or asthma attacks,J. Formos. Med. Assoc. 113: 908-914.. (SCI)
 
26.L.Y. Sung, W. F. Chang, Q Zhang, C. C. Liu, C. C. Chang, H. Fu, J. Y. Liou, W. T. K. Cheng, M. Okuka, D. L. Keefe, Y. E. Chen, L. Liu, C. M. Chen, and J. Xu* 2014/10 Telomere elongation and naïve pluripotent stem cells achieved from telomerase haplo-insufficient cells by somatic cell nuclear transfer.,Cell Reports. 9: 1603-1609. [IF=7.207; Cell Biology, 32/185= Top 17.3%]. (SCI)
 
27.H. L. Chen, Y. T. Tung, C. L. Tsai, C. W. Lai, H. C. Tsai, Y. L. Lin, C. H. Wang, and C.M. Chen 2014/09 Kefir improves fatty liver syndrome through inhibited lipogenesis pathway in leptin-deficient ob/ob knockout mice.,Int. J. Obesity 38 (9): 1172-1179. [IF=5.221; Nutrition & Dietetics, 4/70= Top 5.7%] [Nature系列期刊]. (SCI)
 
28.T. H. Hung, C. M. Chen, C. P. Tseng, C. J. Shen, H. L. Wang, K. B. Choo, and K. Y. Chong 2014/08 FZD1 activates protein kinase C delta-mediated drug-resistance in multidrug-resistant MES-SA/Dx5 cancer cells.,Int. J. Biochem. Cell Biol. 53: 55-65. [IF=4.152; Biochemistry & Molecular Biology 75/290= 25.8%]. (SCI)
 
29.H. C. Liu, S. Y. Pai, H. L. Chen, C. W. Lai, T. C. Tsai, W.T.K. Cheng, S. H. Yang, and C. M. Chen* 2014/07 Recombinant Derp5 secreted in the milk leading by aS1-casein signal peptide protects against dust mite allergen-induced airway inflammation. ,J. Dairy Sci. 97: 6792-6803. (SCI)
 
30.Z. L. Lai, Y. A. Tsou, S. R. Fan, M. H. Tsai, H. L. Chen, J. C. Cheng, and C. M. Chen* 2014/06 Methylation-associated gene silencing of RARB in Areca arcinogens-induced mouse oral squamous cell carcinoma.,BioMed. Res. Int. 2014: e378358. (SCI)
 
31.C. C. Lin*, H. H. Chen, Y. K. Chen, H. C. Chang, P. Y. Lin, I. H. Pan, D. Y. Chen, C. M. Chen, and S. Y. Lin 2014/06 Rice bran feruloylated oligosaccharides activate dendritic cells via toll-like receptor 2 and 4 signaling, Molecules 19: 5325-5347 . (SCI)
 
32.R. H. Lin, C. C. Huang, Y. A. Tsou*, C. D. Lin, M. H. Tsai, J. H. Chen, C. M. Chen* and Y. T. Shiao 2014/06 Correlation between imaging characteristics and microbiology in patients with deep neck infections: A retrospective review of one hundred sixty-one cases. ,Surgical Infect. 15 (6): 794-799. (SCI)
 
33.Y. T. Tung, T. Y. Tang, H. L. Chen, S. H. Yang, K. Y. Chong, and C.M. Chen 2014/06 Lactoferrin protects against chemical-induced rat liver fibrosis through inhibiting stellate cells activation., J. Dairy Sci. 97 (6): 3281-3291. (SCI)
 
34.Y. J. Chen, M. S. Lin, K. Y. Hsu, C. R. Chen, C.M. Chen, and W. Chen 2014/05 Prevalence of asymptomatic peripheral arterial disease and related risk factors in younger and elderly patients in Taiwan. ,Angiology 65 (5): 396-401. (SCI)
 
35.Y. A. Tsou, C. C. Lin, C. J. Tai, M. H. Tsai, T. C. Tsai, and C. M. Chen 2014/04 Chronic rhinosinusitis and the risk of nasopharyngeal cancer in a Taiwanese health study. ,Am. J. Rhinol. Allergy 28 (4):168-172. [MDLinx特別報導; 07/28/2014]. (SCI)
 
36.C. W. Lai, H. L. Chen, K. Y. Lin, F. C. Liu, K. Y. Chong, W. T. K. Cheng, and C.M. Chen 2014/03 FTSJ2, a heat shock-inducible mitochondrial protein, suppresses cell invasion and migration. ,PLoS ONE 9 (3): e90818. (SCI)
 
37.H. L. Chen, C. C. Yen, S. M. Wang, T. C. Tsai, Z. L. Lai, J. Y. Sun, W. Lin, W. H. Hsu, and C. M. Chen 2014/03 Aerosolized bovine lactoferrin reduces lung injury and fibrosis in mice exposed to hyperoxia.,BioMetals 27: 1057-1068. (SCI)
 
38.Y. A. Tsou, M. T. Peng, Y. F. Wu, C. H. Lai, C. D. Lin, C. J. Tai, M. H. Tsai, C. M. Chen*, and H. C. Chen 2014/02 Decreased PLUNC expression in nasal polyps is associated with multibacterial colonization in chronic rhinosinusitis patients.,Eur. Arch. Otorhinolaryngol. 271 (2): 299-304. [Leading News特別報導; 05/07/20. (SCI)
 
39.Y. T. Tung, T. C. Tsai, Y. H. Kuo, H. L. Chen, C. C. Yen, J. Y. Sun, W. H. Chang, H. L. Chen, and C. M. Chen* 2014 Comparison of solid-state-cultured and wood-cultured Antrodia camphorata in anti-inflammatory effects using NF-κB/luciferase inducible transgenic mice.,Phytomedicine 21 (2014): 1708-1716. (SCI)
 
40.S. W. Tsai, H. L. Chen, Y. C. Chang, and C. M. Chen* 2013/12 Molecular Mechanisms of treadmill therapy on neuromusclar atrophy induced via botulinum toxin A.,Neural Plasticity. 2013: e593271. (SCI)
 
41.H. Y. Chen, C. J. Chen, Y. N. Lin, Y. H. Chen, W. C. Chen, and C. M. Chen 2013/12 Proteomic analysis related to stress urinary incontinence following vaginal trauma in female mice.,Eur. J. Obstet. Gynecol. Reprod. Biol. 171 (2013): 171-179. (SCI)
 
42.Y. T. Wang, S. Y. Chang, Y. C. Huang, T. C. Tsai, C. M. Chen, and C. T. Lim 2013/11 Nanomechanics insights into the performance of healthy and osteoporotic bones.,Nano Lett. 13 (11): 5247-5254. [IF=13.025; Nanoscience & Nanotechnology, 4/69= Top 5.8%] [Nanowerk News特別報導; 10/10/2013]. (SCI)
 
43.96. Y. T. Tung, H. L. Chen, H. C. Tsai, S. H. Yang, Y. C. Chang, and C.M. Chen* 2013/11 Therapeutic potential of andrographolide isolated from the leaves of Andrographis paniculata Nees for treating lung adenocarcinomas.,Evid. Complement. Alter. Med. 2013: e305898. (SCI)
 
44.Y. C. Lin, M. C. Lu, C. Lin, M. K. Chiang, M. S. Jan, H. L. Tang, H. C. Liu, W. L. Lin, C. Y. Huang, C.M. Chen* and Y. C. Lai 2013/11 Activation of IFN-r/STAT/IRF-1 in hepatic responses to Klebsiella pneumoniae infection.,PLoS ONE 8 (11): e79961. (SCI)
 
45.91. S. T. Wen, W. Chen, H. L. Chen, C. W. Lai, C. C. Yen, K. H. Lee, and C.M. Chen* 2013/09 Amniotic fluid stem cells from EGFP transgenic mice attenuate hyperoxia-induced acute lung injury.,PLoS ONE 8(9): e75383. (SCI)
 
46.W. Chen, J. Y. Chen, H. L. Chen, Y. T. Tung, C. W. Kuo, F. C. Mao, C. H. Chuang, K. Y. Chong, and C.M. Chen* 2013/09 High-frequency ultrasound imaging to evaluate liver fibrosis progression in rats and Yi Guan Jian herbal therapeutic effects.,Evid. Complement. Alter. Med. 2013: e302325. (SCI)
 
47.J. T. Huang, C. P. Tseng, M. H. Liao, C. H. Lu, W. Z. Yeh, N. Sakamoto,C. M. Chen*, and J. C. Cheng. 2013/09 Hepatitis C virus replication is modulated by the interaction of non-structural protein NS5B and fatty acid synthase,J. Virol. 87(9): 4994-5004. [IF=5.402; Virology, 6/32 = 18.7%] [SciBite: Pharma特別報導; 02/26/2013]. (SCI)
 
48.S. W. Tsai, Y. T. Tung, H. L. Chen, C. J. Shen, C. H. Chuang, T. Y. Tang, and C. M. Chen* 2013/08 Treadmill running upregulates the expression of acetylcholine receptor in rat gastrocnemius following Botulinum Toxin A injection,J. Orthop Res. 31: 125–131. [Science.gov特別報導; 03/15/2013]. (SCI)
 
49.Y. T. Tung, H. L. Chen, C. Y. Lee, Y. C. Chou, P. Y. Lee, H. C. Tsai, C. C. Yen, Y. L. Lin, and C.M. Chen*. 2013/07 Active component of Danshen (Salvia miltiorrhiza Bunge), Tanshinone I, attenuates lung tumorigenesis via inhibitions of VEGF, Cyclin A and Cyclin B expression,Evid. Complement. Alter. Med. 2013: e319247 . (SCI)
 
50.C. M. Chen*, Z. L. Lai, M. L. Wang, and H. L. Chen 2013/06 Cloning and expression of human extracellular superoxide dismutase (EC-SOD) gene in probiotic Lactobacillus casei.,Int. J. Biosci. Biochem. Bioinform. 3(6): 557-561. (SCI)
 
51.H. L. Chen, T. C. Tsai, J. C. Huang, D. C. Wang, and C.M. Chen* 2013/06 Dimorphic goat amelogenin alleles on sex chromosomes for gender determination of preimplantation embryos.,Int. J. Biosci. Biochem. Bioinform. 3(6): 619-623. (SCI)
 
52.Y. A. Tsou, C. C. Lin, C. H. Lai, C. Y. Wang, C. D. Lin, P. C. Chen, I. J. Tsai, C. M. Chen, F. C. Sung*, and M. H. Tsai 2013/05 Does Adenotonsillectomy really reduced clinic visits for pediatric upper respiratory tract infections? A national database study in Taiwan,Int. J. Pediatr. Otorhinolaryngol. 77(5): 677-681. (SCI)
 
53.C. J. Shen, C. C. Lin, P. C. Shen, W. T. K. Cheng, H. L. Chen, T. C. Chang, S. S. Liu, and C. M. Chen* 2013/05 Imprinted genes and satellite are differentially methylated loci in cloned bovine genomes,Cell Reprogram. 15(5): 413-424. (SCI)
 
54.M. S. Lin, K. Y. Hsu, Y. J. Chen, C. R. Chen, C. M. Chen,and W. Chen* 2013/05 Prevalence and risk factors of asymptomatic peripheral arterial disease in patients with COPD in Taiwan,PLoS ONE 8(5): e64714. [IF=4.092; Biology, 12/84 = Top 14.3%]. (SCI)
 
55.Y. T. Tung, C. C. Yen, H. L. Chen, P. Y. Lee, H. C. Tsai, M. F. Lin, and C.M. Chen*. 2013/04 Bovine lactoferrin inhibits lung cancer growth through suppression of inflammation and VEGF expression,J. Dairy Sci. 96(4): 2095-2106. [IF=2.564; Agriculture, Dairy & Animal Science, 2/55 = Top 3.6%]. (SCI)
 
56.Y. A. Tsou#, C. M. Chen#, T. C. Lin, F. W. Hu, C. J. Tai, H. C. Chen, T. H. Yeh, H. J. Harn, M. H. Tsai, and C. I. Jan* 2013/04 Decreased Splunc-1 expression is associated with Pseudomonas infection in surgical treated chronic rhinosinusitis patients who may require repeated sinus surgery, Laryngoscope 123(4): 845-851. #Co-first author. (SCI)
 
57.P. H. Cheng, C. L. Li, S. J. Tsai, Y. Y. Lai, A. W. S. Chan, C.M. Chen, and S. H. Yang* 2013/02 MiR-196a ameliorates phenotypes of Huntington's disease in cell, transgenic mouse and individual-derived induced pluripotent stem cell models.,Am. J. Hum. Genet. 93 (2): 306-312. [IF=10.603; Genetics & Heredity, 8/158= Top 5.1%]. (SCI)
 
58.P. H. Cheng, C. L. Li, L. S. Her, Y. F. Chang, A. W. S. Chan,C.M. Chen, and S. H. Yang. 2013/01 Significantly differential diffusion of neuropathological aggregates in the brain of transgenic mice carrying N-terminal mutant huntingtin fused with green fluorescent protein,Brain Struct. Funct. 218(1): 283-94. [IF=5.628; Anatomy & Morphology, 1/21= Top 4.8%]. (SCI)
 
59.94. H. C. Liu, S. Y. Pai, W. T. K. Cheng, H. L. Chen, T. C. Tsai, S. H. Yang, and C.M. Chen* 2013/01 Ingestion of transgenic animal milks containing the Dp2 peptide, a dust mite allergen, potentially protects mice from allergic airway inflammation and hyper-responsiveness.,Allergy Asthma Clin. Immunol. 9(1): e21. [OtoRhinoLaryngology特別報導; 07/23/2013]. (SCI)
 
60.J. Y. Chen, H. L. Chen, S. H. Wu, T. C. Tsai, M. F. Lin, C. C. Yen, W. H. Hsu, W. Chen, and C. M. Chen* 2012/12 Application of high-frequency ultrasound for the detection of surgical anatomy in the rodent abdomen,Vet. J. 191: 246-252. pp. 246-252. (SCI)
 
61.M. C. Chen, C. Y. Huang, S. L. Hsu, E. Lin, C. T. Ku, H. Lin*, and C. M. Chen* 2012/10 Retinoic acid induces apoptosis of prostate cancer DU145 cells through Cdk5 over-activation,Evid. Complement. Alter. Med. 2012: e580736. (SCI)
 
62.W. C. Chen, K. D. Tsai, C. H. Chen, M. S. Lin, C. M. Chen, C. M. Shih, and W. Chen* 2012/09 Role of Gallium-67 scintigraphy in the evaluation of occult sepsis in the medical ICU,Intern. Emerg. Med. 7: 53-58. (SCI)
 
63.J. Y. Chen, H. L. Chen, J. C. Cheng, H. J. Lin, Y. T. Tung, C. F. Lin, and C.M. Chen* 2012/06 A Chinese herbal medicine, Gexia-Zhuyu Tang (GZT), prevents dimethylnitrosamine-induced liver fibrosis through inhibition of hepatic stellate cells proliferation, J. Ethnopharmacol. 142: 811-818. (SCI)
 
64.Y. J. Chen, Y. T. Chang, J. L. Shen, C. B. Wang, T. Z. Chen,C. M. Chen, and C. Y. Wu* 2012/06 The risk of ischemic heart disease in patients with psoriasis and psoriatic arthritis taking long term methotrexate: a nationwide cohort study,Arthritis & Rheumatism 64(6): 1879-1887. [IF=8.435, Rheumatology 2/29= Top 6.9%]. (SCI)
 
65.J. C. Lai, M. Y. Tu*, C. M. Chen, and F. Y. Wang 2012/03 Spinal epidural abscess in the lumbar spine after dental extraction in a 53-year-old man,Formos. J. Musculoskel. Disor. 3: 144-147. (SCI)
 
66.C. J. Shen, W. T. K. Cheng, S. C. Wu, H. L. Chen, T. C. Tsai, S. H. Yang, and C.M. Chen* 2012/02 Differential differences in methylation status of putative imprinted genes among cloned swine genomes,PLoS ONE 7(2): e32812. [IF=4.411; Biology, 12/86 = Top 14%] . (SCI)
 
67.S.W. Tsai, C.J. Chen, H.L. Chen, C. M. Chen* and Y. Y. Chang 2012/02 The effects of treadmill running on rat gastrocnemius function following botulinum toxin A injection,J. Orthop Res. 30 (2): 319-324. (SCI)
 
68.S. W. Tsai, H. L. Chen, and C.M. Chen* 2012 The effects of treadmill on muscle activity and neuromuscular junction of botulinum toxin-induced muscle atrophy,In: M. C. Rogers and N. D. Peterson, Treadmills: Kinematic variability, uses in therapy and effects on muscle activity. Nova Science Publishers, Inc. New York, USA. pp.1-8.
 
69.C. M. Hung, C. C. Yeh, K. Y. Chong, H. L. Chen, S. T. Kao, C. C. Yen, M. H. Yeh, M. S. Lin, and C. M. Chen* 2011 Gingyo-San enhances peripheral lymphocyte proliferation and assists infectious Bursal disease vaccination in native chicken,Evid. Complement. Alter. Med. 2011: e238208. SCI [IF=4.774, Integrative & complementary medicine, 1/22= Top 4.5%]. (SCI)
 
70.T. C. Tsai, S. H. Wu, H. L. Chen, Y. T. Tung, W. T. K. Cheng, J. C. Huang and C. M. Chen* 2011 Identification of sex-specific polymorphic sequences in goat amelogenin gene for embryo sexing,J. Animal Sci. 89 (8): 2407-2414. SCI [IF=2.580; Agriculture, Dairy & Animal Science,1/55= Top 1.8%]. (SCI)
 
71.Y. T. Chang†,C. M. Chen†, M. Y. Tu, H. L. Chen, S. Y. Chang, T. C. Tsai, Y. T. Wang, and H. L. Hsiao 2011 Effects of osteoporosis and nutrition supplements on structures and nanomechanical properties of bone tissue, J. Mechan. Behav. Biomed. Materi. 4: 1412-1420. SCI [IF=3.176; BioMeterials, ranking 4/25= Top 16%].†Co-first author.. (SCI)
 
72.Y. C. Lin, M. C. Lu, H. L. Tang, H. C. Liu, C. H. Chen, K. S. Liu, C. Lin, C. S. Chiou, M. K. Chiang, C. M. Chen* and Y. C. Lai*. 2011 Assessment of hypermucoviscosity as a virulence factor for experimental Klebsiella pneumoniae infections: comparative virulence analysis with hypermuco- viscosity-negative strain,BMC Microbiology 11:50. SCI [IF=2.890; Microbiology, ranking 35/95= 36.8%](獲選為2011年BMC Open Assess 190種期刊中之Highly Assessed Paper). (SCI)
 
73.Y. T. Tung, H. L. Chen, C. W. Lai, C. J. Shen, Y. W. Lai, and C. M. Chen* 2011 Curcumin reduces pulmonary tumorigenesis in vascular endothelial growth factor (VEGF)-overexpressing transgenic mice, Mol. Nutri. Food Res. 55: 1036-1043. SCI [IF=4.713; Top 1% (1/126)]. pp.1036-1043. (SCI)
 
74.H. C. Liu, M. S. Jan, Y. C. Lin, T. C. Wu, C. N. Huang, C. M. Chen*, and M. C. Lu* 2011 Zygomycosis manifested as chronic mediastinitis and bronchial perforation in a diabetic patient,Eur. Respir. J. 38: 734-735. SCI [IF=5.527; Respiratory System, Top 9.3% (4/43)]. (SCI)
 
75.H. J. Lin, J. Y. Chen, C. F. Lin, S. T. Kao, J. C. Cheng, H. L. Chen, and C.M. Chen* 2011 Hepatoprotective effects of Yi Guan Jian, an herbal medicine, in rats with dimethylnitrosamine- induced liver fibrosis,J. Ethnopharmacol. 134: 953-960. SCI [IF=2.466, Integrative & complementary medicine, ranking 2/17=11.7%]. (SCI)
 
76.C. C. Yen, C. J. Shen, W. H. Hsu, Y. H. Chang, H. T. Lin, H. L. Chen and C. M. Chen*. 2011 Lactoferrin – an iron-binding antimicrobial protein against Escherichia coli infection. ,BioMetals 24: 585-594. SCI [IF=3.172; Biochemistry & Molecular Biology 107/283=37.8%]. (SCI)
 
77.C.C. Yen, Y.W. Lai, H.L. Chen, C.W. Lai, C.Y. Lin, W. Chen, Y.P. Kuan, W.H. Hsu, and C.M. Chen*. 2011 Aerosolized human extracellular superoxide dismutase prevents hyperoxia-induced lung injury,PLoS ONE 6(10): e26870. SCI [IF=4.411; Biology, 12/86 = Top 14%]. (SCI)
 
78.M.S. Lee, C.H. Lin, T.H. Lee, H.M. Wu, C.C. Huang, L.S. Huang, C. M. Chen and E.H. Cheng* 2010 Association of creatin kinase B and peroxiredoxin 2 expression with age and embryo quality in cumulus cells,J. Assist. Reprod. Genet. vol.27, pp.629-639. (SCI)
 
79.K. T. Ho§, M. Y. Shiau, Y. H. Chang, C. M. Chen§, S. C. Yang, and C. N. Huang* 2010 Association of interleukin-4 promoter polymorphisms in Taiwanese patients with type 2 diabetes mellitus,Clin. Exp. 59: 1717-1722. (§ Equal contribution). (SCI)
 
80.T. C. Tsai, W. Lin, S. H. Yang, W.T.K. Cheng, E.H. Cheng, M.S. Lee, K.Y. Chang, and C. M. Chen* 2010 Granzyme G is expressed in the two-cell stage mouse embryo and is required for the maternal-zygotic transition,BMC Dev. Biol. 10: 88. SCI [IF=3.29, Developmental Biology, 10/35=28%](獲選為2010年BMC Open Assess 190種期刊中之Highly Assessed Paper; Assessed Times: 958). (SCI)
 
81.F. C. Liu, H. L. Chen, W. Lin, Y.T. Tang, C.W. Lai, A. L. Hsu, and C. M. Chen* 2010 Application of porcine lipase secreted by Pichia pastoris to improve fat digestion and growth performance of postweaning piglets, J. Agri. Food Chem. 58: 3322-3329. SCI [IF= 2.532; Agriculture, Multidisciplinary 1/35 = 2.9 %]. (SCI)
 
82.H. L. Chen, Y.W. Lai, C. S. Chen, T. W. Chu, W. Lin, C. C. Yen, M. F. Lin, M.Y. Tu, and C. M. Chen*. 2010 Probiotic Lactobacillus casei expressing human lactoferrin elevates antibacterial activity in the gastrointestinal tract,BioMetals. 23: 543-554. SCI [IF=3.172; Biochemistry & Molecular Biology 107/283=37.8%]. (SCI)
 
83.H.J. Lin, C.P. Tseng, C.F. Lin, M.H. Liao, C. M. Chen, S.T. Kao and J.C. Cheng* 2010 A Chinese herbal decoction, modified Yi Guan Jian, induces apoptosis in hepatic stellate cells through a ROS-mediated mitochondrial/ caspase pathway,Evid. Complement. Alter. Med. 2011: e459531. SCI [IF=4.774, Integrative & complementary medicine, 1/22= Top 4.5%]. (SCI)
 
84.C. M. Hung, C. C. Yeh, H. L. Chen, C.W. Lai, M.F. Kuo, M. H. Yeh, W. Lin, M.Y. Tu, H. C. Cheng, and C. M. Chen* 2010 Porcine lactoferrin administration enhances peripheral lymphocyte proliferation and assists infectious bursal disease vaccination in native chickens,Vaccine. 28: 2895-2902. (SCI) SCI [SCI IF= 3.298; Veterinary Sciences, 1/135= Top 1%]. (SCI)
 
85.C. H. Lin, C. J. Chen, C. M. Chen, S. L. Liao, S. L. Raung, and S. W. Tsai 2010 Treatment of atlantoaxial rotatory fixation with botulinum toxin muscle block and manipulation,J. Chin. Med. Assoc. vol.73, pp.222-224. (SCI)
 
86.C. M. Hung, S. C. Wu, C. C. Yen, M. F. Lin, Y. W. Lai, Y. T. Tung, H. L. Chen, and C. M. Chen*. 2010 Porcine lactoferrin as feedstuff additive elevates avian immunity and potentiates vaccination, BioMetals. 23: 579-587. SCI [IF=3.172; Biochemistry & Molecular Biology 107/283=37.8%]. (SCI)
 
87.Y. J. Chen, J. L. Shen, C. Y. Wu, S. Y. Chu, Y. T. Chang, C. M. Chen and F. Y. Lee 2009 Elevated plasma osteopontin level is 1 associated with occurrence of psoriasis and is an unfavorable cardiovascular risk factor in patients with psoriasis, J.Am. Acad. Dermatol. 60(2): 225-230. SCI [IF=2.904; Ranking 5/41 in Dermatology]. (SCI)
 
88.C. C. Yen, C. Y. Lin, K. Y. Chong, T. C. Tsai, C. J. Shen, M. F. Lin, C. Y. Su, H. L. Chen and C. M. Chen* 2009 Lactoferrin as a natural regimen of selective decontamination of the digestive tract, J. Infect. Dis. 199(4): 590-598. SCI [IF=6.288, Infectious diseases, 5/58= Top 8.6%]. (SCI)
 
89.Y. J. Chen, C. Y. Wu, C. C. Chang, C. J. Ma, M. C. Li, and C. M. Chen* 2008 Nuclear Kruppel-like factor 4 expression is associated with human skin squamous cell carcinoma progression and metastasis,Cancer Biol. Ther. vol.7, no.5, pp.777-782. (SCI)
 
90.H. L. Chen, L. C. Wang, C. H. Chang, C. C. Yen, W.T.K. Cheng, S. C. Wu, C. M. Hung, M. F. Kuo, and C. M. Chen* 2008 Recombinant Porcine Lactoferrin Expressed in the Milk of Transgenic Mice Protects Neonatal Mice from a Lethal Challenge with Enterovirus Type 71,Vaccine. 26: 891-898. SCI [SCI IF= 3.298; Veterinary Sciences, 1/135= Top 1%]. (SCI)
 
91.H. L. Chen, J. Y. Huang, T. W. Chu, T. C. Tsai, C. M. Hung, C. C. Lin, L. C. Wang, Y. J. Chen, M. F. Lin, and C. M. Chen*. 2008 Expression of VP1 protein in the milk of transgenic mice: As a potential oral vaccine against for enterovirus 71 strain infection,Vaccine. 26: 2882-2889. SCI [SCI IF= 3.298; Veterinary Sciences, 1/135= Top 1%]. (SCI)
 
92.F. C. Liu, H. L. Chen, K. Y. Chong, A. L. Hsu, and C. M. Chen* 2008 Production of recombinant porcine colipase secreted by Pichia pastoris and its application to improve dietary fat digestion and growth of postweaning piglets,Biotech. Prog. vol.24, pp.1333-1341. (SCI)
 
93.Y. J. Chen, C. Y. Wu, J. L. Shen, S. Y. Chu, C. K. Chen, Y. T. Chang.and C. M. Chen*. 2008 Psoriasis independently associated with hyperleptinemia contributing to metabolic syndrome,Arch Dermatol. 144(12): 1571-1575. SCI [IF=4.231, Dermatology; 5/54= Top 9%][Leading News特別報導] . (SCI)
 
94.K. M. Lin, T. H. Chao, C. M. Chen, L. P. Chen, H. M. Wang, and F. F. Chiang 2007 Methylation of the PCDH21 (Protocadherin-21) gene in colorectal cancer,J. Soc. Colon Rectal Surg. vol.18, pp.93-98. (SCI)
 
95.S. C. Wu, H. L. Chen, C. C. Yen, M. F. Kuo, T. S. Yang, S. R. Wang, C. N. Weng, C. M. Chen*, and W. T. K. Cheng. 2007 Recombinant porcine lactoferrin expressed in the milk of transgenic mice enhances offspring growth J, Agri. Food Chem. 55: 4670-4677. SCI [IF=2.507; Top 3.2% (1/32)] [ACS News特別報導;並被撰文收錄於J. Chem. Edu.期刊作為美國高中及大學生物與化學之參考教材)] . (SCI)
 
96.F. C. Liu, and C. M. Chen* 2007 The effect of dietary addition of the recombinant colipase on growth performance and fat utilization of TLRI black piglets 2wks postweaning,Taiwan Livestock Res. vol.40, pp.169-175.
 
97.H. L. Chen, C. C. Yen, C. Y. Lu, C. H. Yu, and C. M. Chen* 2006 Synthetic porcine lactoferricin with 20-residue peptide exhibits antimicrobial activity against Esch J,Agri. Food Chem. 54: 3277-3282. SCI [IF=2.507; Top 3.2% (1/32)] . (SCI)
 
98.W.T.K. Cheng, S. Y. Pai, C. H. Hsu and C.M. Chen*. 2006 Oral tolerance of allergic airway inflammation and hyper-reactivity by transgenic milk delivering du.
 
99.H.L. Chen, C.C. Yen, T.C. Tsai, C.H. Yu, Y.J. Liou, Y.W. Lai, M.L. Wang, and C.M. Chen* 2006 Production and characterization of hman extracellular superoxide dismutase (ECSOD) in the methylotro J,Agri. Food Chem. 54: 8041-8047. SCI [IF=2.507; Top 3.2% (1/32)][ACS News特別報導] . (SCI)
 
100.C. J. Hu, S. D. Chen, D. I. Yang, T. N. Lin, C. M. Chen, T. H. M. Huang and C. Y. Hsu 2006 Promoter region methylation and reduced expression of thrombospondin-1 after oxygen-glucose deprivat J,Cereb. Blood Flow Metabol. 26: 1519-1526. SCI [IF=5.673; Top 8.6% (17/198)]. (SCI)
 
101.C. C. Yen, S. H. Yang, C. Y. Lin, and C. M. Chen* 2006 Stem cells in the lung parenchyma and prospects for lung injury therapy. Euro. J,Clin. Invest. vol.36, pp.310-319. (SCI)
 
102.C. M. Chen*, W. T. K. Cheng, C. C. Chang, Y. N. Jiang, J. T. Hsu, and T. J. Chang 2005 Cloning, cDNA sequence, and alternative splicing of goat amelogenin mRNAs,Gene (in revised) .
 
103.H. L. Chen, Y. W. Lai, C. C. Yen, Y. Y. Lin, C.Y. Lu, S. H. Yang, T. C. Tsai, C. W. Lin and C. M. Chen* 2005 Production of recombinant porcine lactoferrin exhibiting antibacterial activity in methylotrophic ye J,Mol. Microbiol. Biotechnol. vol.8, pp.141-149. (SCI)
 
104.S. H. Wei, T. C. Yip, and C. M. Chen*. 2005 Identifying clinicopathological association of DNA hypermethylation in cancers using CpG island micr Kluwer Academic. ,NY, USA. pp.107-116.
 
105.S. Y. Pai, S. H. Yang, W. T. K. Cheng, C. H. Hsu and C.M. Chen*. 2004 Desensitivity therapy of allergic airway inflammation and hyper-reactivity by mammary specific expre.
 
106.S. H. Tsai, C. M. Chen, C. S. Chang, and G. H. Chen. 2004 Effect of Helicobacter pylori infection on intragastric acidity in patients with reflux esophagitis,J. Gastroenterol. vol.39, pp.821-826. (SCI)
 
107.C. M. Chen, H. L. Chen, T. H. C. Hsiau, A. H. A. Hsiau, H. Shi, G. J. R. Brock, S. H. Wei, C. W. Caldwell, P. S. Yan, and T. H. M. Huang 2003 Methylation target array for rapid analysis of CpG island hypermethylation in multiple tissue genome Am,J. Pathol. 163: 37-45. SCI [IF= 5.224; Pathology, 4/76= Top 5.3%; Cited times: 80]. (SCI)
 
108.H. Yang, C. M. Chen, P. S. Yan, T. H. M. Huang, H. Shi, M. Burger, I. Nimmrich, S. Maier, K. Berlin, and C. W. Caldwell 2003 The androgen receptor gene is preferentially hypermethylated in follicular non-Hodgkin’s lymphomas,Clin. Cancer Res. 9: 4034-4042. SCI [IF=5.715; Top 12% (15/123)]. (SCI)
 
109.S. H. Wei, C. M. Chen, G. Strathdee, J. Harnsomburana, C. R. Shyu, F. Rahmatpanah, H. Shi, S. W. Ng, P. S. Yan, K. P. Nephew, R. Brown, and T. H. M. Huang 2002 Methylation microarray analysis of late-stage ovarian carcinomas distinguishes progression-free surv Clin,Cancer Res. 8: 2246-2252. SCI [IF= 7.338; oncology, 16/184= Top 8.7%; Cited times: 129]. (SCI)
 
110.C. M. Chen*, C. H. Wang, S. C. Wu, C. C. Lin, S. H. Lin, and W. T. K. Cheng. 2002 Temporal and spatial expression of biologically active human factor VIII in the milk of transgenic m,Transgenic Res. 11: 257-268. SCI [IF=2.284; Top 30% (41/139); Cited times: 12] . (SCI)
 
111.J. C. Wu, C. M. Chen, T. Y. Chiang, W. H. Tsai, W. J. Jeng, I. J. Sheen, C. C. Lin, and X. J. Meng 2002 Spread of hepatitis E virus among different-aged pigs: Two-year survey in Taiwan,J. Med. Virol. 66: 488- 492. SCI [IF=3.188; Top 20% (5/25); Cited times: 31] . (SCI)
 
112.H. Shi, P. S. Yan, C. M. Chen, F. Rahmatpanah, C. Lofton-Day, C. W. Caldwell, and T. H. M. Huang 2002 Expressed CpG island sequence tag microarray for dual screening of DNA hypermethylation and gene silencing,Cancer Res. 62: 3214-3220. SCI [IF= 8.234; oncology, 12/184= Top 6.5%; Cited times: 62]. (SCI)
 
113.C. M. Chen, H. L. Chen, H. Shi, C. W. Caldwell, G. J. R. Brock, P. S. Yan, and T. H. M. Huang. 2002 Complex patterns of DNA methylation in cancer,In: Cancer Epigenetics: DNA methylation and chromatin. Madrid, Spanish.. pp.43-44.
 
114.P. S. Yan, C. M. Chen, H. Shi, F. Rahmatpanah, S. H. Wei, and T. H. M. Huang 2002 Applications of CpG island microarrays for high-throughput analysis of DNA methylation,J. Nutri. 132: 2430- 2434. SCI IF=4.295; Nutrition & Dietetics, 8/70= Top 11.4%; Cited times: 63]. (SCI)
 
115.S. C. Liu, C. M. Chen, and Y. H. Yu 2002 Sex identification of duck embryos by polymerase chain reaction,Taiwan Livestock Res. vol.35, pp.169-173.
 
116.R. S. Gitan, H. Shi, C. M. Chen, P. S Yan, and T. H. M. Huang 2002 Methylation-specific oligonucleotide microarray: A new potential for high-throughput methylation ana Genome Res,[IF= 13.588; Genetics & Heredity, 6/156= Top 3.8%; Cited times: 321]. vol.12, pp.158-164. (SCI)
 
117.G. J. R. Brock, T. H. M. Huang, C. M. Chen, and K. J. Johnson 2001 A novel technique for the identification of CpG islands exhibiting altered methylation patterns (ICEAMP). ,Nucl. Acids Res. 29(24): e123. SCI [IF= 7.836; Biochemistry & Molecular Biology, 30/286= Top 10.4%; Cited times: 33]. (SCI)
 
118.P. S. Yan, C. M. Chen, H. Shi, F. Rahmatpanah, S. H. Wei, C. W. Caldwell, and T. H. M. Huang. 2001 Disecting complex epigenetic alterations in breast cancer using CpG island microarrays, Cancer Res. 61: 8375-8380. SCI [IF= 8.234; oncology, 12/184= Top 6.5%; Cited times: 208]. (SCI)
 
119.J. C. Wu, C. M. Chen, W. H. Tsai, T. Z. Chen, and S. D. Lee 2000 Clinical and epidemiological implications of swine hepatitis E virus infection,J. Med. Virol. vol.60, pp.166-171. (SCI)
 
120.C. M. Chen, Y. C. Chang, H. L. Chen, and W. T. K. Cheng. 2000 High-level expression of growth hormone in the methylotropic yeast and its application on growth imp J,Anim. Sci. vol.13, pp.158-161. (SCI)
 
121.C. M. Chen, Winston T. K. Cheng, Y. C. Chang, T. J. Chang, and C. L. Chen. 2000 Growth enhancement of fowls by dietary administration of recombinant yeast cultures containing enric ,Life Sci. vol.67, pp.2103-2115. (SCI)
 
122.Winston T. K. Cheng, C. H. Lee and C. M. Chen. 2000 Growth hormone gene polymorphisms and growth performance traits in Duroc, ,Landrace and Tao-Yuan pigs Theriogenology . vol.54, pp.1225-1237. (SCI)
 
123.C. M. Hung, T. H. Hong, C. H. Hsu, and C. M. Chen* 2000 Production of anti-insulin monoclonal antibody by a novel immunization protocol and its clinical app J.,Agri. Soci. China. vol.1, pp.343-352.
 
124.C. M. Chen, C. L. Hu, and W. T. K. Cheng 1999 The techniques of bovine embryo sexing,Natl. Sci. Coun. Monthly (ROC) . vol.27, pp.381-392.
 
125.M. F. Kuo, C. M. Chen, H. K. Hu, and W. T. K. Cheng. 1999 The feasibleness of using mouse embryonic stem cells after retrovirus vector-PSN transfection to agg J, Chin. Soc. Anim. Sci. vol.28, pp.471-490.
 
126.C. M. Chen, C. L. Hu, C. H. Wang, C. M. Hung, H. K. Wu, K. B. Choo, and W. T. K. Cheng 1999 Gender determination in single bovine blastomeres by polymerase chain reaction amplification of sex- Mol,Reprod. Dev. vol.54, pp.209-214. (SCI)
 
127.M. F. Kuo, C. M. Chen, H. K. Hu, and W. T. K. Cheng 1998 Integration and expression of porcine growth hormone gene after transfected into the mouse embryonic stem cells by retroviral vector. J,Chin. Soc. Anim. Sci. vol.27, no.1, pp.59-73.
 
128.W. T. K. Cheng, B. C. Chen, S. T. Chiou, and C. M. Chen 1998 Growth hormone gene therapy for growth improvement of swine with nonautologous microencapulated fibr Hum,Gene Ther. 9: 1995-2003. SCI [IF= 4.829; Biotechnology & Applied Microbiology, 19/160= Top 11%; Cited times: 36]. (SCI)
 
129.M. F. Kuo, C. M. Chen, H. K. Hu, and W. T. K. Cheng. 1998 Integration and expression of porcine growth hormone gene after transfected into the mouse embryonic J,Chin. Soc. Anim. Sci. vol.27, no.1, pp.59-73.
 
130.K. B. Choo, C. M. Chen, and W. T. K. Cheng. 1996 1996 Molecular analysis of cellular loci disrupted by papillomavirus 16 integration in cervical cancer: frequent viral integration in topologically destabilized and transcriptionally active chromosomal regions,J. Med. Virol. 49. pp.15-22. (SCI)
 
131.J. C. Wu, C. M. Chen, T. Z. Chen, S. D. Lee, F. S. Yen, and K. B. Choo, 1996 Prevalence and type of precore hepatitis B virus mutants in hepatitis D virus superinfection and its clinical implications,J. Infect. Dis. 173: 457-459. SCI [IF=6.288, Infectious diseases, 5/58= Top 8.6%]. (SCI)
 
132.J. C. Wu, C. M. Chen, I. J. Sheen, S. D. Lee, H. M. Tzeng, and K. B. Choo 1996 Evidence of transmission of hepatitis D virus to spouses from sequence analysis of the viral genome,Hepatology 22: 1656-1660. SCI [IF=10.885; Gastroenterology & Hepatology, 2/71=Top 3%]. (SCI)
 
133.K. B. Choo, C. J. Huang, C. M. Chen, C. P. Han, and L. C. Au, 1995 Jun-B oncogene aberrations in cervical cancer cell lines,Cancer Letters . vol.93, pp.249-253. (SCI)
 
134.C. M. Chen, W. T. K. Cheng, and K. B. Choo, 1995 Frequent deletions and sequence aberrations at the transgene junctions of transgenic mice carrying the papillomavirus regulatory and the SV40 TAg gene sequences,Transgenic Res. vol.4, pp.52-59. (SCI)
 
135.J. C. Wu, K. B. Choo, C. M. Chen, T. Z. Chen, and S. D. Lee 1995 Genotyping of hepatitis D virus by restriction-fragment length polymorphism and relation to outcome of hepatitis D,The Lancet 346: 939-941. SCI [IF=33.633; Medicine, General & Internal, 2/151=Top 1%; Cited times: 87]. (SCI)
 
136.K. B. Choo, C. M. Chen, C. N. Shen, and L. C. Au, 1995 Resolution of uncertainties in restriction maps of cosmid clones by ,Anal. Biochem. vol.288, pp.355-357. (SCI)
 
137.C. M. Chen, M. P. Shyu, L. C. Au, H. W. Chu, W. T. K. Cheng, and K. B. Choo 1994 Analysis of deletion of the integrated HPV16 sequences in cervical cancer: a rapid multiplex PCR approach,J. Med. Virol. vol.44, pp.206-211. (SCI)
 
138.C. M. Chen*, W. T. K. Cheng, and K. B. Choo 1994 Structure analysis of transgenes in transgenic mice: evidence for frequent deletions, insertions and Asian-Aus,J. Anim. Sci. vol.7, pp.15-18. (SCI)
 
139.K. B. Choo, and C. M. Chen, 1994 Cellular genes and sequences disrupted by human papillomavirus integration in cervical cancer,J. Cell. Biochem. vol.18A, pp.224-225. (SCI)
 
140.K. Y. Chong, C. M. Chen, and K. B. Choo 1993 Post-hybridization recovery of DNA from membrane filter for polymerase chain reaction (PCR) amplification. ,BioTechniques. vol.14, pp.575-578. (SCI)
B.研討會論文
 
1.J. C. Yang, H. L. Chen and C. M. Chen*. 2015/10 A novel stem cell therapy approach ameliorates hyperoxia-induced acute lung injury by differentiated amniotic fluid stem cells into lung progeitor cells. ,In The 2015 International Conference on Stem Cells and Developmental Biology.. Oct. 16-17, 2015. Poster No. 34. Taipei, Taiwan..
 
2.C. M. Chen* (Invited Speaker; Organizer) 2015/10 Lung tumorigenesis induced by human vascular endothelial growth factor (hVEGF) overexpression in transgenic mice and amelioration of tumor formation by miR-16.,In The 2015 Symposium on Agricultural and Biological Sciences.. Oct. 27-31, 2015. Guangxi, China..
 
3.Y. S. Huang and C. M. Chen*. (Section Chair) 2015/09 The apoptosis effect of lactoferrin on the HBV-induced hepatocellular carcinoma.,In The 2015 Symposium on Application of Taiwan's Agricultural Biotechnology and Natural Resources. . Sep. 3-4, 2015. Nantou, Taiwan..
 
4.C. M. Chen* (Invited Speaker) 2015/09 Lactoferrin prevents DMN-induced chemical injury of liver fibrosis by inhibiting stellate cell activation.,In The 11th International Symposium on Biocatalysis and Agricultural Biotechnology.. Sep. 13-15, 2015. Banff, Alberta, Canada..
 
5.C. W. Kuo and C. M. Chen* (Invited Speaker) 2015/09 Extracellular superoxide dismutase with heparin binding domain retard the progression of streptozotocin-induced diabetic nephropathy.,In The 4th International Conference on Nephrology and Therapeutics.. Sep. 14-16, 2015. Baltimore, USA..
 
6.C. M. Chen*, Y. T. Tung, P. W. Huang, Y. C. Chou, D. C. Yeh, and J. L. Wang. 2015/03 Dissection of lung tumorigenesis induced by human vascular endothelial growth factor (hVEGF)-A165 overexpression in Clara cells of transgenic mice.,In The 2015 Experimental Biology International Conference.. Mar. 28-Apr. 1, 2015. Boston, MA, USA..
 
7.T. C. Tsai, Y. T. Tung, Y. H. Kuo, J. W. Liao, H. C. Tsai, K. Y. Chong, H. L. Chen, and C. M. Chen*. 2015/03 Anti-inflammatory effects of Antrodia camphorata and its active compound, ergostatrien-3β-ol, in a mouse skin ischemia model., In The 2015 Experimental Biology International Conference. . Mar. 28-Apr. 1, 2015. Boston, MA, USA..
 
8.C. W. Lai (賴政威), H. L. Chen and C. M. Chen*. 2014/10 The systemic promoter driving-EGFP transgenic mice represent a sexual dimorphic EGFP expression in liver: controlled by testosterone during the pubertal period of mice.,In the 15th IUBMB International Conference on “Molecular Medicine and Drug Discovery”.. Poster No. G9-6. Oct. 21-26, 2014. Taipei, Taiwan..
 
9.C. M. Chen*, C. J. Shen, W.T.K. Cheng, and H. L. Chen. 2014/07 Aberrant epigenetic regulation of osteoponin gene in cloned swine genome.,In the 2014 International Conference on Life Science and Biological Engineering.. ID: LSBE-1479, Jul. 21-24. Sapporo, Japan..
 
10.Y. C. Tsai(蔡沂瑾), H. L. Chen, and C. M. Chen*. 2014/03 Kefir prevents the development of fatty liver via AMPK activation to reduce lipogenesis. ,In the 29th Joint Annual Conference of Biomedical Science.. P925, Mar. 15-16, NDMC, Taipei, Taiwan. .
 
11.H. Ou-Yang (歐陽桓), S.C. Wu, T.C. Tsai, W.T.K. Cheng, and C. M. Chen* 2014/03 The mechanism of granzyme G specific expressed in mouse embryo 2-cell stage.,In the 29th Joing Annual Conference of Biomedical Science. . P434, Mar. 15-16, NDMC, Taipei, Taiwan..
 
12.H. N. Wu (吳欣珊), H. L. Chen, and C. M. Chen* 2014/03 Cloning and expression of recombinant wild-type porcine myostatin propeptide and its mutant form in Pichia pastoris.,In the 29th Joint Annual Conference of Biomedical Science.. P613, Mar. 15-16, NDMC, Taipei, Taiwan. .
 
13.Y. H. Chen (陳昱璇), H. L. Chen, C. C. Kao, and C. M. Chen* 2014/03 Kefir-fermented peptides (KFP) exhibiting anti-hypertension and reducing cerebral hemorrhage in stroke-prone spontaneously hypertensive rats.,In the 29th Joint Annual Conference of Biomedical Science.. P610, Mar. 15-16, NDMC, Taipei, Taiwan. (*榮獲2014年第29屆生醫年會_台灣生化與分生學會壁報論文競賽優勝獎).
 
14.C. W. Lai, S. T. Wen, W. Chen, H. L. Chen, C. C. Yen, K. H. Lee, S. C. Wu and C. M. Chen*. 2013/11 Amniotic fluid stem cells from egfp transgenic mice attenuate hyperoxia-induced acute lung injury.,In the 2013 Taiwan Society for Biochemistry and Molecular Biology. . P01. Nov. 22-24. Taichung, Taiwan..
 
15.Y. T. Tung, H. L. Chen, C. L. Tsai, and C. M. Chen*. 2013/11 Kefir improves fatty liver syndrome by inhibiting the lipogenesis pathway in leptin-defective ob/ob knockout mice. ,In the 2013 Taiwan Society for Biochemistry and Molecular Biology.. P21. Nov. 22-24. Taichung, Taiwan..
 
16.T. C. Tsai, Y. T. Tung, Y. H. Kuo, L. T. Chen, W. H. Chang, and C. M. Chen*. 2013/11 Anti-inflammatory effects of antrodia camphorata on hyperoxia-induced systemic inflammatory responses in NF-κB/luciferase transgenic mice., In the 2013 Taiwan Society for Biochemistry and Molecular Biology.. P23. Nov. 22-24. Taichung, Taiwan..
 
17.H. C. Tsai, S. X. Low, and C. M. Chen*. 2013/11 Dissecting microrna profile in hyperglycemia and hypoxia wound healing.,In the 2013 Taiwan Society for Biochemistry and Molecular Biology.. P52. Nov. 22-24. Taichung, Taiwan..
 
18.M. H. Ho, C. L. Tsai, H. L. Chen, and C. M. Chen*. 2013/11 Effects of kefir-fermented peptides on reduction of lipid accumulation in hepatic steatosis cells induced by oleic/palmitic acid. ,In the 2013 Taiwan Society for Biochemistry and Molecular Biology.. P66. Nov. 22-24. Taichung, Taiwan..
 
19.Y. T. Tung, H. L. Chen, H. C. Tsai, S. H. Yang, Y. C. Chang, and C. M. Chen*. 2013/11 Therapeutic potential of andrographolide isolated from the leaves of andrographis paniculata nees for treating lung adenocarcinomas. ,In the 2013 Taiwan Society for Biochemistry and Molecular Biology.. P74. Nov. 22-24. Taichung, Taiwan. (*本篇論文榮獲2013台灣生物化學學會口頭發表論文獎第三名).
 
20.C. M. Chen*, T. C. Tsai, Y. T. Tung, and H. L. Chen. 2013/09 Purification different forms of extracellular superoxide dismutase and their effects on anti-hypertension through nitric oxide induction in spontaneous hypertension rats.,In The 13th International Conference on Endothelin. Sep. 8-11, 2013. Poster No: P.71. Tokyo, Japan..
 
21.H. L. Chen, T. C. Tsai, Y. T. Tung, and C. M. Chen*. 2013/09 Identification and characterization of novel anti-hypertensive peptides obtained from fermented milk.,In The 13th International Conference on Endothelin. Sep. 8-11, 2013. Poster No: P.72. Tokyo, Japan..
 
22.H. L. Chen, T. C. Tsai, J. C. Huang, D. C. Wang, and C. M. Chen*. 2013/08 Amelogenin alleles on sex chromosomes for gender determination of preimplantation goat embryos. ,ICEBB 2013,. August 24-25, 2013. Singapore. .
 
23.145. Y. T. Tung, H. L. Chen, H. C. Tsai, S. H. Yang, Y. C. Chang, and C. M. Chen*. 2013/02 Andrographolide, an active component of Andrographis paniculata Nees, for treating lung adenocarcinomas.,In the 5th International Conference on Drug Discovery & Therapy (ICDDT). . Poster No. PO-107. pp. 103. Feb. 18-21, 2013, Dubai, UAE..
 
24.C. H. Zhuang (莊家輝), H. L. Chen, and C. M. Chen*. 2012/12 The functional assessment of kefir on the postponement of bone loss in ovariectomized rats. ,In the 2012 Conference of Taiwan Society for Biochemistry and Molecular Biology.. Poster No. 68. pp. 106. Dec. 6-8, 2012, Nantou, Taiwan..
 
25.H. L. Chen, Y. W. Lai, and C. M. Chen*. 2012/08 Epigenetic silence of DnaJD1 gene in hepatitis B virus X protein–positive hepatocellular carcinoma. In The 2012 FASEB Summer Research Conference on,“Liver Biology: Fundamental Mechanisms & Translational Applications. Poster No. 6. Jul. 29-Aug. 3, 2012. Snowmass Village, CO, USA..
 
26.H. L. Chen, C. Y. Chen, and C. M. Chen*. 2012/07 A Chinese herbal medicine, Gexia-Zhuyu Tang (GZT), prevents dimethylnitrosamine-induced liver fibrosis through inhibition of hepatic stellate cells proliferation,In The 2012 FASEB Summer Research Conference on “Liver Biology: Fundamental Mechanisms & Translational Applications. Poster No. 9. Jul. 29-Aug. 3, 2012. Snowmass Village, CO, USA..
 
27.C. M. Chen*, H. C. Liu, S. Y. Pai, W. T. K. Cheng, and H. L. Chen 2012/04 Oral administration of transgenic Dp2 peptide-enriched milk induces tolerance from allergic asthma,In The 2012 Experimental Biology International Meeting: Translating Science for Tomorrow’s Health. The FASEB J. 2012; 26: LB197. Apr. 21-25, 2012. San Diego, CA, USA.
 
28.Lu-Tzu Chen(陳律慈), H.L. Chen, and C.M. Chen*. 2012 Nuclear factor kappa B plays an important role during the spermatogenesis development of testis,In the 2012 Asia-Pacific Development Biology Conference Poster No. 2248. Oct. 5-8, 2012. Taipei, Taiwan. .
 
29.W.H. Chang(張雯惠), H.L. Chen, and C.M. Chen*. 2012 Anti-inflammatory effect of lactoferrin on hyperoxia-induced systemic inflammatory responses using NF-κB/luciferase transgenic mice,In the 2012 Asia-Pacific Development Biology Conference. Poster No. 2080. Oct. 5-8, 2012. Taipei, Taiwan.
 
30.C.W. Lai(賴政威), H.L. Chen, and C.M. Chen* 2012 The position effect of transgenic mice causes EGFP gender differential expression in liver. In the 2012 Asia-Pacific Development Biology Conference,Poster No. XP-07. Oct. 5-8. Taipei, Taiwan.
 
31.Y. T. Tung, H. L. Chen, H. C. Tsai, S. H. Yang, Y. C. Chang, and C. M. Chen*. 2012 Therapeutic potential of andrographolide for treating lung adenocarcinomas,In the 5th International Conference on Industrial Bioprocesses. Oct. 7-10, 2012, Taipei, Taiwan., pp.356.
 
32.C. M. Chen*, Y. T. Tung, Y. W. Lai, M. L. Wang, T. C. Tsai, and H. L. Chen. 2012 Cloning and expression of human extracellular superoxide dismutase gene (EcSOD) in food-grade Lactobacillus casei,In the 5th International Conference on Industrial Bioprocesses. Oct. 7-10, 2012, Taipei, Taiwan, pp.357.
 
33.C. J. Shen, W. T. K. Cheng, J. Y. Cheng, H. L. Chen, and C. M. Chen* 2012 Production of multimeric methyl-binding domain (MBD) protein for genome- wide hypermethylated genes screening,In the 5th International Conference on Industrial Bioprocesses. Oct. 7-10, 2012, Taipei, Taiwan, pp.359.
 
34.W.H. Chang(張雯惠), H.L. Chen, C. C. Yen, and C.M. Chen* 2012 Anti-inflammatory pathway of lactoferrin on hyperoxia-induced lung inflammatory responses using NF-κB/luciferase transgenic mice, In the 2012 Eleventh Annual AACR International Conference on Frontiers in Cancer Prevention Research. Poster No. 270347_1.. Oct. 16-19, 2012, Anaheim, California, USA. , pp.168.
 
35.Y. T. Tung (童鈺棠), H. L. Chen, and C. M. Chen* 2012 Tanshinone I attenuates lung tumorigenesis in VEGF-overexpressing transgenicmice via inhibition of tumor-activated cell cycle pathway,In the 2012 Eleventh Annual AACR International Conference on Frontiers in Cancer Prevention Research. Poster No. 247589_1.. Oct. 16-19, 2012, Anaheim, California, USA, pp.133.
 
36.G. J. Wang(王冠傑), H. L. Chen, and C. M. Chen* 2012 Production of recombinant casein phosphopeptide trimer using Pichia pastoris. In the 2012 Conference of Taiwan Society for Biochemistry and Molecular Biology. ,Poster No. 50. Dec. 6-8, 2012, Nantou, Taiwan. , pp.88.
 
37.M.C. Chen, C.Y. Huang, C.T. Ku, H. Lin, and C. M. Chen* 2011/09 The Role of P25/Cdk5 in Retinoic Acid-Triggered Apoptosis of Prostate Cancer Cells,In The 7th FAOPS Congress. Taipei, Taiwan. Sep 11-14, 2011. (oral #O5-05) .
 
38.M.C. Chen, C. M. Chen*, and H. Lin*. 2011 Cyclin-Dependent Kinase 5 Regulates Androgen Production in Mouse Ovary Thecal Cells,Program and Abstract of the 40th Annual Meeting of the Society for the Study of Reproduction (poster #708). July 31-August 4, 2011. Portland, USA..
 
39.J.Y. Sun (孫正岳), H.L. Chen, and C. M. Chen* 2011 Establishment of antihypertensive peptide expressed in transgenic mice mammary system and recombinant Pichia pastoris yeast,In The 2011 Taiwan Society for Biochemistry and Molecular Biology. Poster No. P3.. Nov. 24-25, 2011. Peikong Creek, Nantou, Taiwan. .
 
40.C.L. Tsai (蔡至倫), H.L. Chen, and C. M. Chen*. 2011 Fermented milk improves leptin deletion OB/OB mice induced non-alcoholic fatty liver disease by decreasing lipogenesis genes expression,In The 2011 Taiwan Society for Biochemistry and Molecular Biology Poster No. P50.. Nov. 24-25, 2011. Peikong Creek, Nantou, Taiwan. .
 
41.Y.T. Tung, H.L. Chen, T.C. Tsai, C.W. Lai, C.J. Shen, Y.W. Lai, and C. M. Chen*. 2011 Curcumin reduces pulmonary tumorigenesis in vascular endothelial growth factor,In Annual Meeting of the 102th American Association for Cancer Research (AACR). No.2380. Apri 2-6, Orlando, USA. .
 
42.H.L. Chen, C.W. Lai, C.J. Shen, Y.W. Lai, and C. M. Chen* 2011 Curcumin reduces pulmonary tumorigenesis via inhibition of vascular endothelial growth factor A165 (VEGF-A165) in lung adenocarcinoma cells,In 19th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB). No. C11. . July 15-19, Vienna, Austria. .
 
43.Y.W. Lai, H.L. Chen, J. J.W. Chen and C. M. Chen*. 2011 The effects of methylation-controlled DnaJD1 in hepatitis B virus X protein expressed hepatocellular carcinoma. In Annual Meeting of the 102th American Association for Cancer Research (AACR). NO.2416. Apri 2-6,Orlando, USA.
 
44.C. M. Chen*, T.C. Tsai, W. Lin, S.H. Yang, W. T. K. Cheng, E.H. Cheng, M.S. Lee, and K.Y. Chong 2011 Granzyme G, a serine protease, is expressed in the two-cell stage mouse embryo that required for MZT,. In 19th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB). No. C11. July 15-19. Vienna, Austria.
 
45.J. Y. Chen, H. J. Lin, H.L. Chen and C. M. Chen* 2011 Hepatoprotective and antihepatofibrootic effects of Yi Guan Jian in rats with dimethylnitrosamine-induced liver fibrosis,In The 46th Annual Meeting of the European Association (EASL). . March 30–April 3, Berlin, Germany, pp.241.
 
46.C.W.Lai, K.Y. Lin, F.J. Liou, H.L. Chen, J.C. Cheng and C. M. Chen*. 2011 FTSJ2, a putative ribosomal RNA methyltransferase, suppressed cell invasion and migration in cancer cell line,In Annual Meeting of the 102th American Association for Cancer Research (AACR). No.3877. Apri 2-6, Orlando, USA.
 
47.M.T. Wu(吳敏翠), Y.J. Chen, H.L. Chen and C. M. Chen*. 2011 The tumor suppressor functional studies of protocadherin 19 (PCDH19) gene in hepatoma cell lines,In the 2011 Joined Medical Oncology Conference. A1-37. Apr 30-May 1, Taipei, Taiwan. .
 
48.. J. Shen(沈志傑), J. Cheng, E.H. Hsieh, H. L. Chen and C. M. Chen*. 2011 Methyl-binding domain protein applications for hypermethylated genes identification in cloned porcine and cancer cells,In the 44th Annual Meeting for the Japanese Society of Developmental Biology. P1183. May 17-21, Okinawa, Japan.
 
49.T.C. Tsai (蔡東州), W. Lin, S.H. Yang, W. T. K. Cheng, E.H. Cheng, M.S. Lee, K.Y. Chong and C. M. Chen*. 2011 Granzyme G is expressed in the two-cell stage mouse embryo and is required for the maternal-zygotic transition, In the 44th Annual Meeting for the Japanese Society of Developmental Biology. May 17-21, Okinawa, Japan, pp.1183.
 
50.C. M. Chen* 2010 New strategy of pharmaceutical protein productions by the milks of transgenic cloned animals,In 2010 New Appoaches of Targeted Drug Medical Therapy Conference. Mar. 24-25. Kaohsiung Medical University, Taiwan. (Invited speaker) .
 
51.H. L. Chen, C. J. Shen, S. C. Wu, C. M. Chen*. 2010 Differential epigenetic changes presenting in imprinted genes of cloned swine genomes,In 2010 Lorne Genomics International Conference. Feb. 12-17. Lorne, Melbourne, Australia.
 
52.I. A. Chen, F. C. Liu, H. L. Chen, and C. M. Chen* 2010 Administration of recombinant myostatin propeptide promotes myogensis of C2C12 myoblast cells. In Proc,of the 25th Joint Annual Conference of Biomedical Sciences. P689. Mar. 27-28, NDU, Taipei, Taiwan. .
 
53.T. H. Hung, C. J. Shen, C. M. Chen, and K. Y. Chong 2010 Methylation profiling of CpG islands in multiple drug resistant cell line,In Annual Meeting of the 101th American Association for Cancer Research (AACR). P4914.. Washington DC, USA..
 
54.T. H. Hung, C. P. Tseng, N. Sakamoto, C. M. Chen, and J. C. Cheng 2010 The interaction of non-structure protein NS5B and lipogenic enzyme modulates hepatitis C virus replication,In the 7th International Meeting on Hepatitis C Virus and Related Viruses (HCV2010). P-125. Pacifico Yokohama, Japan.
 
55.C. J. Shen, C. C. Lin, P. C. Shen, W. T. K. Cheng, H. L. Chen, and C. M. Chen*. 2010 Dissecting satellite and imprinting genes methylation status in cloned bovine,Aberrant methylation in imprinting loci. In Annual Meeting of the 101th American Association for Cancer Research (AACR). P173. Apr. 18-22, Washington DC, USA..
 
56.H. L. Chen, C. J. Shen, and C. M. Chen*. 2010 Differential epigenetic changes presenting in imprinted genes of cloned swine genomes,2010 Lorne Genomics International Conference. Feb. 12-17. Lorne, Melbourne, Australia.
 
57.Y. C. Chang, H. L. Chen, Y. J. Chen, and C. M. Chen. 2009/05 Characterization of B domain-deleted recombinant human factor VIII in transgenic pigs,In Proc. of the 14th Taiwan Joint Cancer Conference Molecular Oncology- Pushing Cancer Management, A step forward. A1-19. May 2-3, NDU, Taipei, Taiwan. .
 
58.S. R. Fan, Y. W. Lai, C. F. Lin, N. W. Chang, M. H. Tsai, C. M. Chen, and J. C. Cheng 2009 Identifying DNA methylation status in oral cancers using CpG islands microarray,In Proc. of the 14th Taiwan Joint Cancer Conference: Molecular Oncology- Pushing Cancer Management, A step forward. A1-56. May 2-3, NDU, Taipei, Taiwan.
 
59.C. C. Lin, P. C. Shen, W.T.K. Cheng, C. J. Shen, and C. M. Chen 2009 Epigenetic aberration of imprinting genes in somatic nuclear transferred cloning bovine genomes,In Proc. of 2009 International Symposium of Stem Cells and Biogengineering. P1-1. May 16-17, NCKU Medical College, Tainan, Taiwan. (*本篇論文榮獲第五屆台灣幹細胞學會2009幹細胞與組織工程國際研討會壁報論文優勝獎).
 
60.S. T. Wen, C.W. Lai, C.C. Yen, H. L. Chen, and C. M. Chen. 2009 Identification of mouse amniotic fluid-derived stem cells from eGFP transgenic mice and its application on the repairs of hyperoxia-induced lung injury,In Proc. of 2009 International Symposium of Stem Cells and Biogengineering. P3-3. . May 16-17, NCKU Medical College, Tainan, Taiwan. (*本篇論文榮獲第五屆台灣幹細胞學會2009幹細胞與組織工程國際研討會壁報論文優勝獎).
 
61.H. L. Chen, and C. M. Chen. 2009 Lactoferrin-enriched Milk reduces need for antibiotics in animal feed and enhances offspring growth performance,In China- Taiwan Biotech Interaction Conference. Feb. 4-7, 2009. Fuchou University, China. .
 
62.C. M. Chen*. 2009 The applications of ransgenic cloning animals in phamarceutical protein drugs and subunit vaccines,In Xth Chinese Experimental Animal Society Annual Conference. Nov. 26-27, 2009. Taipei, Taiwan. (Invited speaker) .
 
63.H. L. Chen, C. C. Yen, T. C. Tsai, and C. M. Chen*. 2009 Recombinant porcine lactoferrin expressed in the milk of transgenic mice enhances offspring growth performance,In IXth International Conference on Lactoferrin. P VIII-2. Oct. 18-23, 2009. Beijing, China.
 
64.C. M. Chen*, C. C. Yen, and H. L. Chen. 2009 Lactoferrin as a natural regimen of selective decontamination of the digestive tract,In IXth International Conference on Lactoferrin. P IX-2.. Oct. 18-23, 2009. Beijing, China..
 
65.C. M. Chen*, (Invited speaker) and H. L. Chen. 2009 Lactoferrin-enriched milk protects neonatal from a lethal challenge with enterovirus type 71,In China- Taiwan Biotech Interaction Conference. Feb. 4-7, 2009. Fuchou University, China.
 
66.C. J. Shen, S. C. Wu, W.T.K. Cheng, H. L. Chen, and C. M. Chen 2009 OPN promoter controlled by DNA methylation: Aberrant methylation in cloned porcine,In Annual Meeting of the 100th American Association for Cancer Research (AACR). P3364. Denver, Colorado, USA.
 
67.Y. W. Lai, H. L. Chen, J. Chen, and C. M. Chen 2009 Use of mouse CpG islands microarray for high-throughput analysis of the hepatocellular carcinoma in HBx protein overexpressed transgenic mice,In Annual Meeting of the 100th American Association for Cancer Research (AACR). P5203. Denver, Colorado, USA. .
 
68.C. M. Chen*.(Invited speaker) 2008/07 PCDH21 promoter hypermethylation and gene function studies in sporadic breast tumors and cancer cell lines,In 2008 Taiwan Epigenomics Symposium. July, 25-26, 2008. NCCU, Chia-Yi, Taiwan.
 
69.Y. C. Hung, C. K. Chou, P. J. Tsai, and C. M. Chen 2008 Inflammatory role of NF-kB in hyperoxia-induced lung injury,In 2008 Chinese-Taipei Society of Laboratory Animal Sciences Anneal Conference. Dec. 4-5, 2008. Taipei, Taiwan. (*本篇論文榮獲第十屆中華實驗動物學會2008學術研討會壁報論文優勝獎) , pp.101.
 
70.. L. Chen, W. E. Chen, Y. W. Lai, and C. M. Chen 2008 Epigenetic downregulation of death-associated protein kinase in hepatocellular carcinoma,In the AACR International Special Conference: Infection and Cancer – Biology, Therapeutics, and Prevention. B26, pp.40. Hong Kong Academy of Medicine, Hong Kong.
 
71.C. J. Shen, S. C. Wu, W. T. K. Cheng, T. C. Tsai, C. H. Chen, H. L. Chen, and C. M. Chen 2008 Dissecting epigenetic changes of imprinting genes in cloned porcine,In the 9th Developmental Biology Conference. Sep. 5-6. . National Chung Hsing University. O-06. (*本篇論文榮獲第九屆發育生物學研討會口頭發表最佳內容獎) .
 
72.M.F. Lin, M. H. Lee, Y. C. Chen, L. S. Ju, M. Y. Huang, C. J. Chang, C. H. Chen, Y. W. Lai, C. J. Shen, and C. M. Chen 2008 CpG island microarray analysis of gene expression in urothelial cell carcinoma,2008 Urology Medical Annual Conference. PD10. Aug. 30-31. Fu-Jen Catholic University, Taipei county, Taiwan. (*本篇論文榮獲2008台灣泌尿科醫學年會最佳海報論文獎) .
 
73.H. L. Chen, C. C. Yen, and C. M. Chen. 2008 Lactoferrin-enriched milk reduces need for antibiotics in animal feed and enhances offspring growth performance,In International Conference of 2008 Nutrigenomics. 17-18 March, Paris, France.
 
74.Y. C. Chou, P. W. Huang, H. C. Ho, H. L. Chen, and C. M. Chen 2008 Molecular mechanism of pulmonary tumorigenesis induced by VEGF-A165 overexpression in the tissue of transgenic mice,In Proc. of the 23th Joint Annual Conference of Biomedical Sciences. P697. Mar. 29-30, NDU, Taipei, Taiwan. (*本篇論文榮獲第二十三屆生物醫學年會之台灣生物化學及分子生物學學會最佳論文獎) .
 
75.C. M. Chen*, Y. J. Lin, and H. L. Chen. 2008 Methylation profiling of five selected genes on chromosome 16 in human hepatocellular carcinomas,In the AACR International Special Conference: Infection and Cancer – Biology, Therapeutics, and Prevention. B25. Dec. 5-7, 2008. Hong Kong Academy of Medicine, Hong Kong., pp.39..
 
76.C. M. Chen, H. L. Chen, C. M. Hung, and W.T.K. Cheng 2008 Lactoferrin-enriched milk protects neonatal from a lethal challenge with enterovirus type 71,In International Conference of 2008 Nutrigenomics. 17-18 March, Paris, France.
 
77.J. T. Huang, C. P. Tseng, N. Sakanoto, S. C. Lu, C. M. Chen, and J. C. Cheng 2008 A novel NS5B-interacting protein modulates hepatitis C virus replication,In 15th International Symposium on Hepatitis C Virus & Related Viruses. P417. October 5-9, 2008. Marriott Rivercenter, San Antonio, Texas, USA. .
 
78.S. T. Wen, H. L. Chen, and C. M. Chen 2008 Identification of mouse amniotic fluid-derived stem cells from eGFP transgenic mice and its application on the repairs of hyperoxia-induced lung injury,4th International Conference on Stem Cell Research and Therapeutics. April 17-18. Boston, MA, USA. .
 
79.C. J. Shen, S. C. Wu, W. T. K. Cheng, T. C. Tsai, H. L. Chen, and C. M. Chen 2008 Characterization of epigenetic methylation changes of four imprinting genes in cloned porcine,4th International Conference on Stem Cell Research and Therapeutics. April 17-18. Boston, MA, USA. .
 
80.. L. Chen, C. C. Yen, and C. M. Chen*. 2007 Synthetic Porcine Lactoferricin with 20-Residue Peptide Exhibits Antimicrobial Activity against Escherichia coli, Staphylococcus aureus and Candida albicans, In Symposium of International Developments in Science and Health Claims. 9-11 May 2007, Malta.Europe .
E.技術報告
 
1.C. M. Chen 2005 Production of recombinant human FVIII therapeutic protein by animal biotechnology and its applicatio Agriculture Biotechnology. (ROC). 3: 21-27. (GPN 2009305478).
 
2.C. M. Chen*, and H. L. Chen 2005 The development of CpG islands microarray technique and its applications on embryogenesis and tumorgenesis. Life Sci. Newsletter, NSC (ROC).
 
3.C. M. Chen 2004 Transgenic DNA determination by PCR screening and slot blot quantitative hybridization. In: Transgenic Animal Technology and Protocol. M. C. Huang. Ministry of Education Press, Taiwan (ROC). Pp. 335-340. (ISBN 957-01-7605-9.
 
4.C. M. Chen 2004 The research and development of transgenic animal biotechnology in biomedical sciences. In: The Development of Animal Biotechnology Industry. Pung Tung Agricultural Biotechnology Park Council of Agriculture, Executive Yuan Press, Taiwan (ROC). Pp. 2.
 
5.C. M. Chen 2004 The recombination mechanism of concatamerization and integration of exogenous genes in the chromosome of transgenic animals. In: Transgenic Animal Technology and Protocol. M. C. Huang. Ministry of Education Press, Taiwan (ROC). Pp. 189-200. (ISBN 95.
 
6.C. M. Chen 2004 The protocol for transgenic DNA purification and quantification. In: Transgenic Animal Technology and Protocol. M. C. Huang. Ministry of Education Press, Taiwan (ROC). Pp. 297-302. (ISBN 957-01-7605-9.
 
7.S. H. Wei, T. C. Yip, C. M. Chen, and T. H. M. Huang 2003 Identifying clinicopathological association of DNA hypermethylation in cancers using CpG island microarrays. In: DNA Methylation and Cancer Therapy. Moshe Szyf, McGill University Press. Montreal, Quebec, Canada. Pp. 1-11. (ISBN 1417574585.
 
8.C. M. Chen 2003 The development and application of transgenic animal systems in biopharmaceuticals. Biotech Taiwan (ROC). Vol. 1: 16-.
 
9.C. M. Chen* and H. L. Chen 2003 Applications of methylated gene microarray on biology research. In: Research Technology to Adiopocyte Biology. S. T. Ding and W. T. K. Cheng. National Library Press, Taiwan Pp. 124-130. (ISBN 957-01-5467-5).
 
10.C. M. Chen*, and H. D. Yen 2000 The report of animal science congress in the Asian-Australasian association of animal production societies. Natl. Sci. Coun. Monthly (ROC) 28: 982-985. (ISSN 0250-1651).
 
11.C. M. Chen, W. T. K. Cheng, C. C. Chang, T. L. Weng, Y. N. Jiang, and J. T. Hsu 1999 Capra hircus X chromosome amelogenin (gAML-X) mRNA, complete cds., 752 base pairs. Accession number: AF21589.
 
12.C. M. Chen*, C. C. Chang, T. L. Weng, and W. T. K. Cheng 1999 Capra hircus amelogenin gene located on Y chromosome (gAML-Y), complete intron 5 sequence, 1780 base pairs Accession number: AF21588.
 
13.C. M. Chen*, C. C. Chang, T. L. Weng, and W. T. K. Cheng 1999 Capra hircus amelogenin gene located on X chromosome (gAML-X), complete intron 5 sequence, 1577 base pairs. Accession number: AF21588.
 
14.C. M. Chen, W. T. K. Cheng, C. C. Chang, T. L. Weng, Y. N. Jiang, and J. T. Hsu 1999 Capra hircus Y chromosome amelogenin (gAML-Y) mRNA, complete cds., 746 base pairs. Accession number: AF21588.
 
15.C. M. Chen*, C. L. Hu, and W. T. K. Cheng 1999 techniques of bovine embryo sexing. Natl. Sci. Coun. Monthly (ROC) 27: 381-392. (ISSN 0250-1651.
 
16.W. T. K. Cheng, C. M. Chen, C. L. Hu, C. H. Wang, and K. B. Choo 1996 Bos taurus chromosome Y amelogenin (AMLY) gene, complete intron 5 sequences, 1539 base pairs. Accession number: L4860.
 
17.W. T. K. Cheng, C. M. Chen, C. L. Hu, C. H. Wang, and K. B. Choo 1996 Bos taurus chromosome X amelogenin (AMLX) gene, complete intron 5 sequences, 1684 base pairs. Accession number: L4860.
 
18.C. M. Chen*, W. T. K. Cheng, and K. B. Choo 1995 Homo sapiens PID-2 gene, chromosome recombination site, papillomavirus integration-disrupted cellular locus. Accession number: L4299.
 
19.C. M. Chen*, W. T. K. Cheng, and K. B. Choo 1995 Homo sapiens PID-3 gene, chromosome recombination site, papillomavirus integration-disrupted cellular locus. Accession number: L4230.
 
20.C. M. Chen*, W. T. K. Cheng, and K. B. Choo 1995 Homo sapiens PID-1 gene, chromosome recombination site, derived from CaSki cell line. Accession number: L4299.
 
21.C. M. Chen 1994 Major histocompatibility complex and its role in poultry productions. World's poultry Science Assoc. (ROC) 19:22-3.
F.專利
 
1.H. L. Chen, C. M. Chen 2010 -2029 Novel Antihypertensive Peptide And Use Thereof. USA Patent,No.7,763,281 B2.
 
2.C. M. Chen*, and H. L. Chen 2008 Novel Enterovirus type 71 capsid protein VP1 (EV71-VP1) gene and its production method. USA Patent, , No. US-2010-0125918-A1.
 
3.C. M. Chen*, and H. L. Chen 2008 Novel Enterovirus type 71 capsid protein VP1 (EV71-VP1) gene and its production method. Taiwan Patent,,No. 097139140; pending.
 
4.C. M. Chen, H. L. Chen and C. C. Huang 2008 Novel Mer B enzyme act as a potential antidote against methylmercury toxicity expressed in transgenic milks. Taiwan Patent,No.097141690 .
 
5. S. C. Wu, W.T.K.Cheng, C. M. Chen, S. P. Lin, C. H. Yen, and P. C. Yang 2007 -2026. Method for expressing human clotting factor IX and lactoferrin proteins in the lactating milk of transgenic non-human mammals. Taiwan Patent,No. I273.
 
6.W.T.K. Cheng, C.M. Chen, S. H. Lin, C. H. Wang, C. J. Lin, and S. C. Wu 2007 -2025. Method for transgenic animals producing biologically active human factor VIII in their milk driven by mammary-specific expression cassette with intact or B-domain-deleted gene constructs. Taiwan Paten,No. I287578.
 
7.H. L. Chen, C. M. Chen 2007 Novel Antihypertensive Peptide And Use Thereof. Taiwan Patent,,No. 096135346.
 
8.F. C. Liu, C. M. Chen 2007 Isolation of Porcine Colipase And Use Thereof. Taiwan Patent,No.11/901,989.
 
9.S. C. Wu, W. T. K.Cheng, C. M. Chen, S. P. Lin, C. H. Yen, and P. C. Yang 2006 -2025. Method for expression multiple recombinant proteins in the milk of transgenic non-human mammals. USA Patent,No. 7,087,808.
 
10.C. M. Chen*, H. L. Chen, and W. T. K. Cheng 2006 -2025 Transgenic Animals Producing Low-Lactose Milk and Newly Identified Human Small Intestinal Extracellular Lactase-phlorizin Hydrolase (ecLPH) Gene. USA Patent,No.7,501,554 B.
 
11.C. M. Chen*, H. L. Chen, and W. T. K. Cheng 2006 Transgenic Animals Producing Low-Lactose Milk and Newly Identified Human Small Intestinal Extracellular Lactase-phlorizin Hydrolase (ecLPH) Gene. Taiwan Patent,No. 095117017.
 
12.C. M. Chen, P. S. Yan, and T. H. M. Huang 2002 Methylation target array (MTA) for high-throughput analysis of promoter hypermethylation in multiple tissue genomes. USA, Canada, Europe, Japan, Australia Patents, (pending.
 
13.C.M. Chen W.T.K.Cheng, C. H. Hsu 2002 Allergen-containing transgenic milk for allergy treatment. European Patent, Application number: 02252702.2; pendin.
 
14.C. M. Chen*, C. C. Chang, T. L. Weng, and W. T. K. Cheng 2001 -2019. Procedure for gender determination of goat embryos by sex-specific sequences of goat amelogenin gene. Taiwan Patent,No. 140,077.
 
15.C. H. Hsu, W.T.K.Cheng, C. M. Chen 2001 Allergen-containing transgenic milk for allergy treatment. USA Patent,09/877,160.
 
16.C. H. Hsu, W.T.K.Cheng, C.M. Chen 2001 Allergen-containing transgenic milk for allergy treatment. USA Patent,09/877,16.
 
17.C. M. Chen*, and M. F. Kuo 2000 The Process for growth improvement of fowls using recombinant rGH-enriched yeast culture as feedstuff additive. USA Patent,No.09/563,742.
 
18.W. T. K. Cheng, C. M. Chen, C. L. Hu, C. H. Wang, and K. B. Choo 1999 -2017. Process for sexing cow embryos. USA Patent,No.5,876,942.
 
19.W. T. K. Cheng, C. M. Chen, C. L. Hu, C. H. Wang, and K. B. Choo 1999 -2017 Sex-specific sequences identified from amelogenin gene in the Holstein dairy cattle and method devel Taiwan Patent,No. 101,194.
G.學術活動
 
1.陳全木等 2010 年澳洲Lorne基因體國際研討會.
 
2.陳全木等 2010 頂尖大學研發長訪英暨『台-英高等教育論壇.
 
3.陳全木等 2009/09 頂尖大學研發長訪歐盟-比利時、德國、法國.
 
4.陳全木等 2009 第100屆AACR美國癌症年.