蘇鴻麟[ 教授 ]

神經幹細胞實驗室
辦公室電話: (04) 22840416 # 417
實驗室電話: (04) 22840416 # 418
傳   真: (04) 22854391
實驗室位置: 402台中市南區國光路250號生命科學大樓4F 418
最高學歷: 國防醫學院生命科學研究所博士
專長領域: 胚胎幹細胞、神經科學、病毒學 
電子信箱: suhonglin@gmail.com
實驗室網站:  
 
年份 標題
2015 中興大學 產學績優教師
2016 中興大學 產學績優教師
2015 科技部 幹細胞、醫工、骨科學門 複審委員
2014 中興大學 研究績優教師
2013 Editorial Board member of Biomed Research International
2013 第六屆臺法前鋒科學論壇國際成員養成會議
2012 台灣幹細胞學會理事委員
2012 Editorial board member of Cell Transplantation
2010 中興大學傑出貢獻獎
2009 中興大學傑出青年教師獎
 
畢業學校 主修學門系所 學位 時期
國防醫學院 生命科學研究所 博士 1997-2001
國防醫學院 微生物及免疫學研究所 碩士 1995-1997
台灣大學 獸醫學系 學士 1988-1993
 
服務機關 服務部門 職稱 時期
中興大學生命科學系 生命科學系 教授 2013,08-
中興大學 生物科技發展中心 研發組組長 2013,02-2015,01.31
國立中興大學 生物科技發展中心 服務推廣組組長 2011.08-2013,01
國立中興大學 生命科學系 副教授 2010,08-2013,07
國立中興大學 生命科學系 助理教授 2005,02-2010,07
日本財團法人先端醫療振興財團 事業化推進部 主任研究員 2002-2005
日本理化學研究所 發生‧再生科學總合研究中心 訪問研究員 2002-2005
國立中山大學 生物醫學研究所 博士後研究員 2001-2002
 
研究興趣
1.遺傳性與退化性神經疾病之細胞模式的建立
2.由胚胎幹細胞分化成為特定的神經細胞,如多巴胺神經細胞與運動神經細胞
3.體外粒線體的遞送與治療

研究主題
1.胚幹細胞的神經分化
2.阿茲海默症的藥物開發
3.粒線體遞送與疾病治療

目前研究計畫
科技部 以粒線體遞送治療不孕症
教育部 邁頂計畫 動物疫苗
 
博士班
林智堯 郭啟中 吳詩芳 蔡昇峰 黃茂軒 莊弘盟 莊介森

碩士班
黃隆永、楊雅晴、江承運、黃逸軒、張㚬瑋、胡智勝、李亦可

大學部
林曉瑜

研究助理
許萌琮

博士後研究
申靜懿

畢業生
洪達任(碩96畢),高榮惠(碩96肄)、包翊絹(碩97畢),黃柏瑞(碩97畢),張兆嶔(碩97畢), 吳雅婷 (碩98畢),林智堯(碩98畢),張嘉佑(碩98畢),林秀鴻(碩99畢),丁筱茜(碩99畢),喬書荷(碩100畢),陳嬿如(碩101畢),蔡詠任(碩101畢),阮植垠(碩101畢),張菀婷(碩101畢),陳靜雯(博100畢),郭淑明(博100畢),陳聖美(博101畢),劉人瑋 (博102畢),曾莉萍(博士後研究員),李琇琴(博102肄),吳詩芳(碩102畢),沈博文(碩102畢),陳姵穎(碩102畢),葉文瑜(碩102畢),陳逸茵(碩102畢),曾學敏(碩103畢),張滋麟(碩103畢),賴正國 (博103畢),蔡筱琪(博103畢),黃柏瑞 (博104畢),申仕政(博103畢),張嘉佑 (博104畢),郭珊珊(碩104畢)
 
A.期刊論文
 
1.Chang, J.C., S.L. Wu, K.H. Liu, Y.H. Chen, C.S. Chuang, F.C. Cheng, H.L. Su, Y.H. Wei, S.J. Kuo, and C.S. Liu, 2016 Allogeneic/xenogeneic transplantation of peptide-labeled mitochondria in Parkinson's disease: restoration of mitochondria functions and attenuation of 6-hydroxydopamine-induced neurotoxicity.,Transl Res,. vol.170, pp.40-56. (SCI)
 
2.Chen, Y.H., C.C. Chung, Y.C. Liu, S.P. Yeh, J.L. Hsu, M.C. Hung, H.L. Su, and L.Y. Li, 2016 Enhancer of Zeste Homolog 2 and Histone Deacetylase 9c Regulate Age-Dependent Mesenchymal Stem Cell Differentiation into Osteoblasts and Adipocytes. ,Stem Cells. vol.34, no.8, pp.2183-93.. (SCI)
 
3.Chiang, C.Y., S.A. Liu, M.L. Sheu, F.C. Chen, C.J. Chen, H.L. Su, and H.C. Pan 2016 Feasibility of Human Amniotic Fluid Derived Stem Cells in Alleviation of Neuropathic Pain in Chronic Constrictive Injury Nerve Model,PLoS One. vol.11, no.7, pp.e0159482.. (SCI)
 
4.Chuang, C.S., H.L. Su, C.L. Lin, and C.H. Kao 2016 Risk of Parkinson disease after organophosphate or carbamate poisoning,Acta Neurol Scand, . (SCI)
 
5.Chuang, H.M., H.L. Su, C. Li, S.Z. Lin, S.Y. Yen, M.H. Huang, L.I. Ho, T.W. Chiou, and H.J. Harn, 2016 The Role of Butylidenephthalide in Targeting the Microenvironment Which Contributes to Liver Fibrosis Amelioration. ,Front Pharmacol, . vol.7, pp.112.
 
6.Huang, P.J., C.C. Kuo, H.C. Lee, C.I. Shen, F.C. Cheng, S.F. Wu, J.C. Chang, H.C. Pan, S.Z. Lin, C.S. Liu, and H.L. Su 2016 Transferring Xenogenic Mitochondria Provides Neural Protection Against Ischemic Stress in Ischemic Rat Brains. ,Cell Transplant.. vol.25, no.5, pp.913-27.. (SCI)
 
7.Lu, Y.C., M.L. Lin, H.L. Su, and S.S. Chen, 2016 ER-Dependent Ca++-mediated Cytosolic ROS as an Effector for Induction of Mitochondrial Apoptotic and ATM-JNK Signal Pathways in Gallic Acid-treated Human Oral Cancer Cells.,Anticancer Res. vol.36, no.2, pp.697-705.. (SCI)
 
8.Or, C.R., H.L. Su, W.C. Lee, S.Y. Yang, C. Ho, and C.C. Chang, 2016 Diphenhydramine induces melanoma cell apoptosis by suppressing STAT3/MCL-1 survival signaling and retards B16-F10 melanoma growth in vivo,Oncol. Rep. (SCI)
 
9.Pai, C.L., Y.C. Chen, C.Y. Hsu, H.L. Su, and P.S. Lai 2016 Carbon Nanotube-Mediated Photothermal Disruption of Endosomes/Lysosomes Reverses Doxorubicin Resistance in MCF-7/ADR Cells,J Biomed Nanotechnol, . vol.12, no.4, pp.619-29.. (SCI)
 
10.Chang, C.Y., S.M. Chen, H.E. Lu, S.M. Lai, P.S. Lai, P.W. Shen, P.Y. Chen, C.I. Shen, H.J. Harn, S.Z. Lin, S.M. Hwang, and H.L. Su, 2015 N-butylidenephthalide attenuates Alzheimer's disease-like cytopathy in Down syndrome induced pluripotent stem cell-derived neurons,Sci Rep.. vol.5, pp.8744. (SCI)
 
11.Chang, Y.J., H.L. Su, L.F. Hsu, P.J. Huang, T.H. Wang, F.C. Cheng, L.W. Hsu, M.S. Tsai, C.P. Chen, Y.L. Chang, A.S. Chao, and S.M. Hwang, 2015 Isolation of Human Neural Stem Cells from the Amniotic Fluid with Diagnosed Neural Tube Defects.,Stem Cells Dev.. vol.24, no.15, pp.1740-50.. (SCI)
 
12.Chen, C.J., F.C. Cheng, H.L. Su, M.L. Sheu, Z.H. Lu, C.Y. Chiang, D.Y. Yang, J. Sheehan, and H.C. Pan 2015 Improved neurological outcome by intramuscular injection of human amniotic fluid derived stem cells in a muscle denervation model. ,PLoS One. vol.10, no.5, pp.e0124624. (SCI)
 
13.Chen, S.M., M.S. Lee, C.Y. Chang, S.Z. Lin, E.H. Cheng, Y.H. Liu, H.C. Pan, H.C. Lee, and H.L. Su 2015 Prerequisite OCT4 Maintenance Potentiates the Neural Induction of Differentiating Human Embryonic Stem Cells and Induced Pluripotent Stem Cells. ,Cell Transplant.. vol.24, no.5, pp.829-44..
 
14.Lai, C.K., J.C. Su, Y.H. Lin, C.S. Chang, C.L. Feng, H.J. Lin, C.J. Lin, G.C. Tseng, H.H. Liu, J.T. Hsieh, H.L. Su, and C.H. Lai 2015 Involvement of cholesterol in Campylobacter jejuni cytolethal distending toxin-induced pathogenesis. ,Future Microbiol.. vol.10, no.4, pp.489-501.. (SCI)
 
15.Sun, C.K., F.Y. Lee, Y.H. Kao, H.J. Chiang, P.H. Sung, T.H. Tsai, Y.C. Lin, S. Leu, Y.C. Wu, H.I. Lu, Y.L. Chen, S.Y. Chung, H.L. Su*, and H.K. Yip* 2015 Systemic combined melatonin-mitochondria treatment improves acute respiratory distress syndrome in the rat. ,J. Pineal Res.. vol.58, no.2, pp.137-50.. (SCI)
 
16.Systemic combined melatonin-mitochondria treatment improves acute respiratory distress syndrome in the rat. 2015 Galangin Prevents Acute Hepatorenal Toxicity in Novel Propacetamol-Induced Acetaminophen-Overdosed Mice.,J. Med Food. vol.18, no.11, pp.1187-97.. (SCI)
 
17.Tsai HC, Su HL, Huang CY, Fong YC, Hsu CJ, Tang CH. 2014/06 CTGF increases matrix metalloproteinases expression and subsequently promotes tumor metastasis in human osteosarcoma through down-regulating miR-519d.,Oncotarget. vol.5, no.11, pp.3800-12.
 
18.Tseng LP, Juan CY, Lin SL, Doran MR, Lin JJ, Hsu SH, Liao JW, Shen CI and Su HL*. 2014/05 Nanohybrids of silver particles on clay platelets delaminate Pseudomonas biofilms, Nanomedicine (Lond). vol.9, no.6, pp.803-17.
 
19.Tsai HC, Huang CY, Su HL and Tang CH 2014/05 CTGF increases drug resistance to paclitaxel by upregulating 1 survivin expression in human osteosarcoma cells ,BBA-Molecular Cell Research. vol.1843, no.5, pp.846-54. (SCI)
 
20.Chen YJ, Cheng FC, Sheu ML, Su HL, Chen CJ, Sheehan J, Pan HC 2014/04 Detection of subtle neurological alterations by the Catwalk XT gait analysis system.,J. Neuroeng Rehabil.. vol.11, pp.62.
 
21.Tsai HC, Huang CY, Su HL, Tang CH. 2014/03 CCN2 enhances resistance to cisplatin-mediating cell apoptosis in human osteosarcoma.,PLoS One. vol.9, no.3, pp.e90159.
 
22.Chiang CY, Sheu ML, Cheng FC, Chen CJ, Su HL, Sheehan J, Pan HC. 2014/01 Comprehensive analysis of neurobehavior associated with histomorphological alterations in a chronic constrictive nerve injury model through use of the CatWalk XT system.,J. Neurosurg.. vol.120, no.1, pp.250-62..
 
23.Kuo CH, Lu CY, Yang YC, Chin C, Weng BC, Liu CJ, Chen YH, Chang LL, Kuo FC, Wu DC, Su HL 2014 Does long-term use of silver nanoparticles have persistent inhibitory effect on H. pylori based on Mongolian gerbil's model?,Biomed Res Int. vol.2014, pp.461034.
 
24.Huang MH, Lin SZ, Lin PC, Chiou TW, Harn YW, Ho LI, Chan TM, Chou CW, Chuang CH, Su HL, Harn HJ. 2014 Brain tumor senescence might be mediated by downregulation of S-phase kinase-associated protein 2 via butylidenephthalide leading to decreased cell viability.,Tumour Biol.. vol.35, no.5, pp.4875-84.
 
25.Chen CL, Wang LJ, Yan YT, Hsu HW, Su HL, Chang FP, Hsieh PC, Hwang SM, Shen CN. 2014 Cyclin D1 acts as a barrier to pluripotent reprogramming by promoting neural progenitor fate commitment.,FEBS Lett.. (SCI)
 
26.Shen CI, Lee, HC, Kao YH, Wu CS, Chen PH, Lin SZ, Lai PS and Su HL*. 2014 EpCAM induction functionally links to the Wnt-enhanced cell proliferation in human keratinocytes,Cell Transplant.. vol.23, no.8, pp.1031-44..
 
27.Chen, C.L., L.J. Wang, Y.T. Yan, H.W. Hsu, H.L. Su, F.P. Chang, P.C. Hsieh, S.M. Hwang, and C.N. Shen 2014 Cyclin D1 acts as a barrier to pluripotent reprogramming by promoting neural progenitor fate commitment.,FEBS Lett.. vol.588, no.21. (SCI)
 
28.Lai, C.K., Y.K. Rao, K.R. Chang, C.W. Lin, H.L. Su, C.S. Chang, C.H. Lai, and Y.M. Tzeng 2014 3,3',4', 5'-Tetramethoxychalcone inhibits human oral cancer cell proliferation and migration via p53-mediated mitochondrial-dependent apoptosis. ,Anticancer Res. vol.34, no.4, pp.1811-9. (SCI)
 
29.Shen, S.C., C.I. Shen, H. Lin, C.J. Chen, C.Y. Chang, S.M. Chen, H.C. Lee, P.S. Lai, and H.L. Su 2014 Susceptibility of human embryonic stem cell-derived neural cells to Japanese encephalitis virus infection. ,PLoS One. vol.9, no.12, pp.e114990. (SCI)
 
30.Lai CK, Lu YL, Hsieh JT, Tsai SC, Feng CL, Tsai YS, Tsai PC, Su HL*., Lin YH*, Lai CH*. 2014 Development of chitosan/heparin nanoparticle-encapsulated cytolethal distending toxin for gastric cancer therapy,Nanomedicine (Lond). vol.9, no.6, pp.803-17. (SCI)
 
31.Chang JC, Liu KH, Chuang CS, Su HL, Wei YH, Kuo SJ, Liu CS. 2013/12 Treatment of human cells derived from MERRF syndrome by peptide-mediated mitochondrial delivery.,Cytotherapy. vol.15, no.12, pp.1580-96.
 
32.Lai CH, Lai CK, Lin YJ, Hung CL, Chu CH, Feng CL, Chang CS and Su HL*. 2013/06 Characterization of putative cholesterol recognition/1 interaction amino acid consensus-like motif of Campylobacter jejuni cytolethal distending toxin C,PLoS ONE. vol.8, no.6, pp.e66202.
 
33.Kuo SM, Kao HW, Hou MH, Wang CH, Lin SH and Su HL* 2013 Evolution of infectious bronchitis virus in Taiwan,positively selected sites in the nucleocapsid protein and their effects on RNA-binding activity. Vet Microbiol.162. pp.408-18 .
 
34.Cheng, FC, Sheu, ML, Su HL, Chen, YJ, Chen, CJ, Chiu, WT, Sheehan, J. and Pan, HC 2013 The effect of exercise on mobilization of hematopoietic progenitor cells involved in the repair of sciatic nerve crush injury J,Neurosurgury.118(3):. pp.594-605..
 
35.Liu JW, Hsu YC, Kao CY, Su HL*., Chiu IM*. 2013 LIF-induced Stat3 signaling suppresses FGF1-induced Erk1/2 activation to inhibit the downstream differentiation in mouse embryonic stem cells,Stem Cells Dev.22(8):. pp.1190-7.
 
36.Kuo CC, Tsai HY, Lin JG, Su HL., Chen YF 2013 Spinal Serotonergic and Opioid Receptors Are Involved in Electroacupuncture-Induced Antinociception at Different Frequencies on ZuSanLi (ST 36) Acupoint,Evid Based Complement Alternat Med.. vol.2013, pp.291972.
 
37.Huang CP, Chen HN, Su HL., Hsieh CL, Chen WH, Lai ZR, Lin YW 2013 Electroacupuncture Reduces Carrageenan- and CFA-Induced Inflammatory Pain Accompanied by Changing the Expression of Nav1.7 and Nav1.8, rather than Nav1.9, in Mice Dorsal Root Ganglia,Evid Based Complement Alternat Med. 2013:312184.
 
38.Lu HE, Yang YC, Chen SM, Su HL, Huang PC, Tsai MS, Wang TH, Tseng CP,Hwang SM 2012 Modeling Neurogenesis Impairment in Down Syndrome with Induced Pluripotent Stem Cells from Trisomy 21 Amniotic Fluid Cells Exp,Cell Res. 319(4). pp.498-505.
 
39.Yang DY, Sheu ML, Su HL. Cheng FC, Chen YJ, Chen CJ, Chiu WT, Yiin JJ, Sheehan J, Pan HC 2012 Dual regeneration of muscle and nerve by intravenous administration of human amniotic fluid-derived mesenchymal stem cells regulated by stromal cell-derived factor-1α in a sciatic nerve injury model, J Neurosurg. 116(6). pp.1357-67.
 
40.Chiao SH, Lin SH, Shen CI, Liao JW, Bau IJ, Wei JC, Tseng LP, Hsu SH, Lai PS, Lin SZ, Lin JJ* and Su HL* 2012 Efficacy and Safety of Nanohybrids Comprising Silver Nanoparticles and Silicate Clay for Controlling Salmonella Infection Int,Int. J. Nanomed. 7:. pp.2421-32 .
 
41.Sheu ML, Cheng FC, Su HL, Ying-Ju Chen YJ, Chen CJ, Chiang CM, Chiu WT, Sheehan J and Pan HC 2012 Recruitment by SDF-1α of CD34-positive cells involved in sciatic nerve regeneration, J Neurosurg. 116(2). pp.432-44.
 
42.Lai CY, Ou YC, Chang CY, Pan HC, Chang CJ, Liao SL, Su HL* and Chen CJ* 2012 Endothelial Japanese encephalitis virus infection enhances migration and adhesion of leukocytes to brain microvascular endothelia via MEK-dependent expression of ICAM1 and the CINC and RANTES chemokines, J. Neurochem. 123(2):. pp.250-261.
 
43.Shen CI, Wang CH, Shen SC, Lee HC, Liao JW* and Su HL*. 2011 The infection of chicken tracheal epithelial cells with a H6N1 avian influenza virus, PLoS ONE.6(5):e18894 .
 
44.Lin ML, Lu YC, Su HL, Lin HT, Lee CC, Kang SE, Lai TC, Chung JG, and Chen SS 2011 Destabilization of CARP mRNAs by Aloe-Emodin Contributes to Caspase-8–Mediated p53-Independent Apoptosis of Human Carcinoma Cells J,Cell. Biochem. 112. pp.1176-91.
 
45.Chang CY, Shen CC, Su HL*, Chen CJ* 2011 Gefitinib induces apoptosis in human glioma cells via targeting Bad phosphorylation J,Neuro-Oncology. 105(3). pp.507-22.
 
46.Su HL*, Lin SH, Wei JC, Pao IC, Chiao SH, Huang CC, Lin SZ and Lin JJ* 2011 Novel Nanohybrids of Silver Particles on Clay Platelets for Inhibiting Silver-Resistant Bacteria PLoS ONE. 6(6):e2112.
 
47.Pan HC, Sheu ML, Su HL. Chen YJ, Chen CJ, Yang DY, Chiu WT, Cheng FC 2011 Magnesium Supplement Promotes Sciatic Nerve Regeneration and Down-regulates Inflammatory Response,Magnesium Research.24(2):. pp.54-70.
 
48.Pan HC, Wu YT, Shen SC, Wang CC, Tsai MS, Cheng FC, Lin SZ, Chen CW, Liu CS and Su HL*. 2011 Characterization of Axon Formation in the Embryonic Stem Cell-Derived Motoneuron, Cell Transplantation. 20(4):. pp.493-502.
 
49.Lin CD, Lai CK, Lin YH, Hsieh JT, Sing YT, Chang YC, Chen KC, Wang WC, Su HL, Lai CH 2011 Cholesterol Depletion Reduces Entry of Campylobacter jejuni Cytolethal Distending Toxin and Attenuates Intoxication of Host Cells,Infect Immun. 79(9):. pp.3563-75.
 
50.Wei JC, Yen YT, Su HL, Lin JJ. 2011 Inhibition of bacterial growth by the exfoliated clays and observation of physical capturing mechanism J,Phy. Chem. C, 115,. pp.18770-75.
 
51.Shen CI, Wang CH, Liao JW, Hsu TW, Kuo SM and Su HL*. 2010 The infection of primary avian tracheal epithelial cells with infectious bronchitis virus,Vet. Res. 41:06. .
 
52.Chen CW, Liu CS, Chiu IM, Shen SC, Pan HC, Lee KH, Lin SZ and Su HL*. 2010 The signals of FGFs on the neurogenesis of embryonic stem cells,J. Biomed. Sci. 17:33. .
 
53.Li PR, Wei JC, Chiu YF, Su HL. Peng FC, Lin JJ. 2010 Evaluation on cytotoxicity and genotoxicity of the exfoliated silicate nanoclay,ACS Appl Mater Interfaces. 2:. pp.1608-13.
 
54.Kuo SM, Wang CH, Hou MH, Huang YP, Kao HW and Su HL*. 2010 Evolution of infectious bronchitis virus in Taiwan,Characterisation of RNA recombination in the nucleocapsid gene. Vet. Microbiol. 144:. pp.293-302. .
 
55.Chuang CS, Su HL, Cheng FC, Hsu S, Chuang CF, and Liu CS 2010 Quantitative Evaluation of Motor Function Before and After Engraftment of Dopaminergic Neurons in a Rat Model of Parkinson's Disease,J. Biomed. Sci. 17:9. .
 
56.Su HL*, Chou CC, Hung DJ, Lin SH, Pao IC, Lin JH, Huang FL, Dong RX and Lin JJ*. 2009 The Disruption of Bacterial Membrane Integrity through ROS Generation Induced by Nanohybrids of Silver and Clay,Biomaterials. 30:. pp.5979-5987.
 
57.Chang JC, Hsu SH* and Su HL 2009 The regulation of the gap junction of human mesenchymal stem cells through the internalization of quantum dots,Biomaterials. 30: 1937-1946. IF=7.9 .
 
58.Chang JC, Su HL and Hsu SH. 2008 The use of peptide-delivery to protect human adipose-derived adult stem cells from damage caused by the internalization of quantum dots,Biomaterials. 29. pp.925-936.
 
59.Tsao CH, Su HL, Lin YL, Yu HP, Kuo SM, Shen CI, Chen CW. and Liao CL*. 2008 Japanese encephalitis virus infection activates caspases-8 and -9 in FADD-independent and mitochondrion-dependent manner,J. Gen. Virol. 89,. pp.1930-41.
 
60.Su HL, Muguruma K, Kengaku M, Watanabe K and Sasai Y. 2006 Generation of Cerebellar Neuron Precursors from Embryonic Stem Cells,Dev. Biol. 290:. pp.287-296.
 
61.Su HL, Liao CL and Lin YL 2002 Japanese encephalitis virus infection initiates endoplasmic reticulum stress and an unfolded protein response, J Virol. 76:. pp.4162-71.