陳鴻震[ 教授 ]

腫瘤細胞學研究室
辦公室電話: (04) 2284-0320 # 703
實驗室電話: (04) 2284-0320 # 704, 705
傳   真: (04) 2285-3469
實驗室位置: 生命科學大樓 703 室
最高學歷: 美國康乃爾大學病理系博士
專長領域: 細胞移動與腫瘤轉移。 細胞附著及生長因子對細胞功能之調節。 致癌基因與細胞訊息傳遞。  
電子信箱: hcchen@dragon.nchu.edu.tw
實驗室網站:  
 
年份 標題
2016.3 榮獲『科技部104年度傑出研究獎』
2011 –迄今 國立中興大學榮譽特聘教授
2011 國家衛生研究院頒獎表揚執行「國家衛生研究院整合性醫藥衛生科技研究計畫」三次以上
2009 國立中興大學建教合作計畫績優獎
2007-2011 國立中興大學特聘教授
2003-2005 榮獲『國科會傑出研究獎』
2001 榮獲『國立中興大學青年教師研究獎』
2001 榮獲『中央研究院年輕學者研究著作獎』
2001 獲頒「興大之光」獎牌
2016.8 指導台中女中李岱芸同學參加第56屆全國中小學科展榮獲動物與醫學學科第二名
2016.7 指導研究生林宛儀榮獲2016生物醫學國際研討會論文優等獎
2016.7 指導博士後研究員陳建霖榮獲2016生物醫學國際研討會論文特優獎
2016.3 指導研究生郭偲琳榮獲第三十一屆生物醫學聯合學術年會優秀看板論文獎
2015.6 指導研究生張珀瑋榮獲103學年度中興大學生科系碩士畢業論文特優獎
2015.6 指導大學生王奕勛榮獲103學年度中興大學生科系學士畢業論文特優獎
2015.5 指導研究生許文馨榮獲三分鐘生科論文口說競賽全國網路人氣獎
2015.5 指導研究生張珀瑋榮獲三分鐘生科論文口說競賽中興校內佳作
2014.3 指導研究生蔡宛臻榮獲第二十九屆生物醫學聯合學術年會優秀看板論文獎
2013.12 指導研究生潘羿汝榮獲第九屆永信李天德醫藥科技獎-傑出論文獎
2013.11 指導研究生詹博兆榮獲2013年台灣生化及分生學會冬令營優秀論文壁報獎(博班組)
2013.11 指導研究生許文馨榮獲2013年台灣生化及分生學會冬令營優秀論文壁報獎(碩班組)
2012.7 指導大學生許文馨榮獲100學年度中興大學生科系學士畢業論文特優獎
2012.5 指導研究生潘羿汝榮獲第九屆林榮耀教授學術教育基金會優秀論文獎
2012.1 指導研究生潘羿汝榮獲第二十屆細胞及分子生物新知研討會徐千田優秀論文獎
2012.12 指導研究生王舒慧榮獲台灣生化及分生學會冬令營口頭論文競賽(碩班組)第一名
2012.12 指導研究生潘羿汝榮獲台灣生化及分生學會冬令營口頭論文競賽(博班組)第二名
2012 指導研究生潘羿汝榮獲2012轉譯醫學之基因體與蛋白質體臨床應用研討會壁報論文競賽第一名(台灣基因體暨遺傳學會)
2012 指導研究生卓克桓榮獲2012轉譯醫學之基因體與蛋白質體臨床應用研討會壁報論文競賽第三名(台灣基因體暨遺傳學會)
2012 指導博士後詹博兆榮獲2012轉譯醫學之基因體與蛋白質體臨床應用研討會壁報論文競賽佳作(台灣基因體暨遺傳學會)
2011.3 指導研究生潘羿汝榮獲第二十六屆生物醫學聯合學術年會優秀看板論文獎
2011.11 指導研究生呂瑛哲榮獲台灣生物化學及分子生物學學會秋令營英語口頭論文競賽B組第三名
2011 指導研究生呂瑛哲及曾瑋珊榮獲轉譯醫學之基因體與蛋白質體臨床應用研討會壁報競賽第一名及第二名
2010.11 指導博士後研究員詹博兆榮獲台灣生物化學及分子生物學學會秋令營英語口頭論文競賽A組第三名
2010 指導研究生陳宗華榮獲第二十五屆生物醫學聯合學術年會優秀看板論文獎
2009 指導研究生陳建霖榮獲前瞻性生物醫學暨科學新知研討會(第六屆財團法人台北市林榮耀教授學術教育基金會)優秀論文獎
2008 指導台中一中學生鄭經倫參加台灣國際科學展覽會榮獲醫學及健康科學類第三名(第一及第二名從缺)
2008 指導研究生陳建霖榮獲第十六屆(97年度)中華民國細胞及分子生物學學會「徐千田優秀論文獎」
2008 指導研究生潘羿汝榮獲第二十三屆生物醫學聯合學術年會優秀看板論文獎
2008 指導研究生陳建霖榮獲第二十三屆生物醫學聯合學術年會優秀看板論文獎
2007 指導研究生陳淑怡榮獲第二十二屆生物醫學聯合學術年會優秀看板論文獎
2007 指導研究生陳淑怡榮獲第十五屆(96年度)中華民國細胞及分子生物學學會「徐千田優秀論文獎」
2007 指導研究生陳建霖榮獲第二十二屆生物醫學聯合學術年會優秀看板論文獎
2005 指導研究生張連成榮獲第十三屆(94年度)中華民國細胞及分子生物學學會優秀看板論文獎
2004 指導研究生陳淑怡榮獲第十二屆(93年度)中華民國細胞及分子生物學學會優秀看板論文獎
2003 指導研究生陳柏樺榮獲第十一屆(2003年)中華民國細胞及分子生物學學會「徐千田優秀論文獎」
2003-2004 指導研究生詹博兆連續榮獲第十一及十二屆(92及93年度)中華民國細胞及分子生物學學會「徐千田優秀論文獎」
2002 指導研究生陳彥伶榮獲第十七屆(91年度)生物醫學聯合學術年會優秀看板論文獎
1999 指導大學生邱嘉傑榮獲88學年度國科會大專生參與專題研究計畫「研究創作獎」
 
畢業學校 主修學門系所 學位 時期
美國康乃爾大學 病理系 博士 1991.08 - 1995.05
國立中興大學 獸醫學研究所 碩士 1989.09 - 1991.06
國立中興大學 獸醫學系 學士 1984.09 - 1989.06
 
服務機關 服務部門 職稱 時期
國立陽明大學 生命科學院 院長 2017.02 - 迄今
國立陽明大學 生化暨分子生物研究所 教授 2017.02-迄今
國立中興大學 生命科學系 特聘教授 2007.08-迄今
國立中興大學 生物醫學研究所 合聘教授 2007-迄今
科技部 生科司生化及藥理醫學學門 召集人 2017/01 –迄今
國立中興大學 校友總會 名譽理事 2016/01 –迄今
國立中興大學 校友總會 顧問 2012.10 – 2015.06
國立中興大學 生命科學院 院長 2010.08-2016.07
中華民國細胞及分子生物學學會 理事 2011.05-迄今
台灣基因體暨遺傳學會 理事 2014.05-迄今
中華存善慢飛天使關懷協會 監事 2015.12-迄今
國際生物化學及分子生物學聯盟(IUBMB) Young Scientists Program 主席 2014.01-2014.12
國際生物化學及分子生物學聯盟(IUBMB) Travel Fellowship Committee 2014.01-2014.12
國際生物化學及分子生物學聯盟(IUBMB) Delegate of Adhering Bodies 台灣代表 2012.05-2015.06
亞洲及大洋洲生物化學家及分子生物學家聯盟(FAOBMB) 台灣代表 Council Member 2012.06-2015.06
亞洲及大洋洲生物化學家及分子生物學家聯盟(FAOBMB) Travel Fellowship Committee 2012.06-2015.06
台灣生物化學及分子生物學學會 理事長 2012.07-2015.06
台灣生物化學及分子生物學學會 理事 2010.06-2012.05
美國密西根大學 內科系 訪問教授 2008.07-2009.07
國立中興大學 生命科學院 代理院長 2007.01-2007.07
國立中興大學 生命科學系 教授 2001.08-迄今
國立中興大學 生物醫學研究所 所長 2001.08-2007.07
國立中興大學 生物科技發展中心研發推動組 組長 2001.08 - 2006.07
國立中興大學 動物學系 副教授 1996.08-2001.07
美國康乃爾大學 分子醫學系 博士後研究 1995.06-1996.05
 
研究方向
1.細胞有絲分裂之調控
2.中間絲細胞骨架之調控
3.細胞移動與腫瘤轉移
4.細胞附著及生長因子對細胞功能之調節


目前研究計畫
1.探討Adducin-1在維持紡錘體端點完整性的角色。科技部。(2016/08-2019/07)
2.探討致癌因子Src在調控vimentin細胞骨架的角色。科技部。(2014/08-2017/07)
3.探討酪胺酸去磷酸SHP2在podosome rosette組裝及分裂過程中的角色探討JNK在Podosome 形成過程中的角色。科技部。(2013/08-2016/07)
4.探討JNK在Podosome形成過程中的角色。科技部。(2011/08-2014/07)
5.探討Adducin在有絲分裂過程中所扮演的角色。國佳衛生研究院。(2012/1/1-2014/12/31)
6.探討Adducin分布在細胞內不同位置的機轉及其生物意義。科技部。(2010/08-2013/07)
7.Focal Adhesion Kinase在Podosome Ring形成過程中的角色。科技部。2008/08 -2011/07)
8.Ras活化Src的機轉及其生物意義。國家衛生研究院。(2008/01 - 2010/12)
9.探討肝細胞生長因子接受體與focal adhesion kinase間的作用其作用生物意義。基因體醫學國家型計畫。 (2006/05-2009/04)
10.PKC delta在肝細胞生長因子所引起的細胞功能中所扮演的角色。科技部。(2005/08 – 2008/07)
11.國立中興大學生物科技與奈米科技跨領域整合計畫。教育部。(2004)
12.中部科學工業園區生物科技產業關鍵性技術平台之建立與整合。科技部。(2003)
13.探討FAK基因剔除造成細胞移動缺陷的原因。科技部。(2003/08–2006/07)
14.探討肝細胞生長因子引起持續性ERK活化的機轉及其在細胞功能上的意義。科技部。 (2002/08–2005/07)
15.探討肝細胞生長因子引起上皮細胞轉變為間質細胞的機轉。科技部。(2001/08–2002/07)
16.Focal adhesion kinase在致癌基因met的生理及病理過程中所扮演的角色。科技部。(1999/08–2002/07)
 
博士班
許文馨

碩士班
蘇珈誼 郭偲琳 楊承益 褚璟彤 張崧年

大學部
謝于宣 胡哲瑋 顏睿良

研究助理
陳貞如

博士後研究
陳建霖 范嘉榕
 
A.期刊論文
 
1.Leu, C.-M., Hsu, W.-H., Lin, W.-Y., and Chen, H.-C.* 2016/05 Adducin family proteins possess different nuclear export potential ,Journal of Biomedical Science. vol.24, no.30. (SCI)
 
2.Chen, C.-L., Wang, S.-H., Chan, P.-C., Shen, M.-S., Chen, H.-C. 2016 Phosphorylation of E-cadherin at threonine 790 by protein kinase Cδ reduces β-catenin binding and suppresses the function of E-cadherin.,Oncotarget. vol.7, pp.37260-37276. (SCI)
 
3.Chen CH, Chang WH, Su KY, Ku WH, Chang GC, Hong QS, Hsiao YJ, Chen HC, Chen HY, Wu R, Yang PC, Chen JJ, Yu SL.* 2016 HLJ1 is an endogenous Src inhibitor suppressing cancer progression through dual mechanisms. ,Oncogene . vol.35, pp.5674-5685. (SCI)
 
4.Kao, S.-L., Chen, C.-.L., Pan, Y.-R., and Chen, H.-C.* 2016 Biogenesis of podosome rosettes through fission (in revision). (SCI)
 
5.Chang, C.-H., Chan, P.-C., Li, J.-R., Chen, C.-J., Shieh, J.-J., Fu, Y.-C., Chen, H.-C.,* and Wu, M-.J.* 2015 Gab1 is essential for membrane translocation, activity and integrity of mTORCs after EGF stimulation in urothelial cell carcinoma.,vol.6, pp.1478-1489. (SCI)
 
6.Tsai, W.-C., Chen, C.-L., Chen, H.-C. 2015 Protein tyrosine phosphatase SHP2 promotes invadopodia formation through suppression of Rho signaling.,oncotarget. vol.6, pp.23845-23856. (SCI)
 
7.Chan, P.-C., Hsu, Rosaline Y.-C., Liu, C.-W., Lai, C.-C. and Chen, H.-C.* 2014 Adducin-1 is essential for mitotic spindle assembly through its interaction with myosin-X,Journal of Cell Biology. vol. 204 , no.1, pp.19-28 . (SCI)
 
8.Hsieh, Y.-T., Chou, M.–M., Chen, H.-C.,* and Tseng, J.-J.* 2013 IMP1 promotes choriocarcinoma cell migration and invasion through novel effectors RSK2 and PPME1.,oncology. vol.131, pp.182-190. (SCI)
 
9.Pan, Y.-R., Cho, K.-H., Lee, H.-H., Chang, Z.-F., and Chen, H.-C.* 2013 Protein tyrosine phosphatase SHP2 suppresses podosome rosette formation in Src-transformed fibroblasts,Journal of Cell Science. vol.126, pp.657-666. (SCI)
 
10.Pan, Y.-R., Tseng, W.-S., Chang, P.-W., Chen and H.-C. 2013 Phosphorylation of moesin by Jun N-terminal kinase is important for podosome rosette formation in Src-transformed fibroblasts.,Journal of Cell Science. vol.126, no.24, pp.5670-5680. (SCI)
 
11.Pan, Y.-R., Cho, K.-H., Lee, H.-H., Chang, Z.-F., and Chen, H.-C.* 2013 Protein tyrosine phosphatase SHP2 suppresses podosome rosette formation in Src-transformed fibroblasts,Journal of Cell Science. vol.126, no.24, pp.5670-5680. (SCI)
 
12.Chan, P.-C. and Chen, H.-C.* 2012 P120RasGAP-medaited activation of c-Src is critical for oncogenic Ras to induce tumor invasion,Cancer Research . vol.72, no.9, pp.2405-2415. (SCI)
 
13.Lu, Y.-C. and Chen, H.-C.* 2011 Involvement of lipid rafts in adhesion-induced activation of Met and EGFR,Journal of Biomedical Science 18: 78. (SCI)
 
14.Pan, Y.-R., Chen, C.-L., and Chen, H.-C.* 2011 FAK is required for the assembly of podosome rosettes.,Journal of Cell Biology 195. pp.113-129. (SCI)
 
15.Chen, C.-L., Lin, Y.-P., Lai, Y.-C., and Chen, H.-C.* 2011 α-Adducin translocates to the nucleus upon loss of cell-cell adhesions,Traffic 12. pp.1327-1340.
 
16.Chen, T.-H., Chan, P.-C., Chen, C.-L., and Chen, H.-C.* 2011 Phosphorylation of focal adhesion kinase on tyrosine 194 by Met leads to its activation through relief of autoinhibition ,Oncogene 30. pp.153-166. (SCI)
 
17.Chen, C.-L., Chan, P.-C., Wang, S.-W., Pan, Y.-R., and Chen, H.-C.* 2010 Elevated expression of protein kinase Cδinduces cell scattering upon serum deprivation,Journal of Cell Science 123. pp.2901-13. (SCI)
 
18.Chan, P.-C., Sudhakar, J. N., Lai, C.-C., and Chen, H.-C.* 2010 Differential phosphorylation of the docking protein Gab1 by c-Src and the hepatocyte growth factor receptor regulates different aspects of cell functions,Oncogene 29. pp.698-710. (SCI)
 
19.Chen C.-L and Chen, H.-C.* 2009 Functional suppression of E-cadherin by protein kinase Cδ,Journal of Cell Science 122. pp.513-523. (SCI)
 
20.Lee, H.-H., Chang, S.-S., Lin, S.-J., Chua, H.-H., Tsai, T.-J., Tsai, K., Lo, Y.-C., Chen, H.-C. and Tsai, C.-H.* 2008 Essential role of PKCd in histone deacetylase inhibitor-induced Epstein-Barr virus reactivation in nasopharyngeal carcinoma cells,Journal of General Virology 89. pp.878-883. (SCI)
 
21.Kao SC, Chen CY, Wang SL, Yang JJ, Hung WC, Chen YC, Lai NS, Liu HT, Huang HL, Chen H-C, Lin TH, Huang HB 2007 Identification of phostensin, a PP1 F-actin cytoskeleton targeting subunit. ,Biochem. Biophys. Res. Commun. 356. pp.594-598. (SCI)
 
22.Chen, C.-L., Hsieh, Y.-T., and Chen, H.-C.* 2007 Phosphorylation of adducin by protein kinase C delta promotes cell motility,Journal of Cell Science 120. pp.1157-1167. (SCI)
 
23.Lee, W.-C., Wu, M.-J., Cheng, C.-H., Chen, C.-H., Wen, M.-C., Chen, H.-C., and Shu, K.-H.* 2006 Acute pancreatitis following antilymphocyte globulin therapy in a renal transplant recipient,Clinical Nephrology 65. pp.144-146. (SCI)
 
24.Chen, J.T., Lin, T.S., Chow, K.C.*, Huang, H.H., Chiou, S.H., Chiang, S. F., Chen, H.-C., Chuang, T.L., Lin, T.Y., and Chen, C.Y. 2006 Cigarette smoking induces overexpression of hepatocyte growth factor in type II pneumocytes and lung cancer cells,American Journal of Respiratory Cell and Molecular Biology 34. pp.264-273. (SCI)
 
25.Chan, P.C., Chen, S.Y., Chen, C.H., and Chen, H.-C*. 2006 Crosstalk between hepatocyte growth factor and integrin signaling pathways,Journal of Biomedical Science 13. pp.215-223.. (SCI)
 
26.Chen, S.Y. and Chen, H.-C.* 2006 Direct interaction of focal adhesion kinase (FAK) with MET is required for FAK to promote hepatocyte growth factor-induced cell invasion,Molecular and Cellular Biology 26. pp.5155-5167. (SCI)
 
27.Chiang, C.-J., Chen, H.-C., Chao, Y.-P., and Tzen, J.T.C.* 2006 One-step purification of insoluble hydantoinase overproduced in Escherichia coli,Protein Expression and Purification 52. pp.14-18. (SCI)
 
28.Hsin, Y.-H., Cheng, C.-H., Tzen, J.T.C., Wu, M.-J., Shu, K.-H., and Chen, H.-C.* 2006 Effect of aristolochic acid on intracellular calcium concentration and its links with apoptosis in renal tubular cells,Apoptosis11. pp.2167-2177. (SCI)
 
29.Chiang, C.J., Chen, H.-C., Huo, H.-F., Chao, Y.-P., and Tzen, J. T. C.* 2006 A simple and effective method to prepare immobilized enzymes using artificial oil bodies,Enzyme and Microbial Technology 39. pp.1152-1158. (SCI)
 
30.Chiang, C.-J., Chen, H.-C., Chao, Y. P., and J.T.C. Tzen.* 2005 An efficient system of artificial oil bodies for functional expression and purification of recombinant nattokinase in Escherichia coli,J. Agric. Food Chem. 53. pp.4799-4804. (SCI)
 
31.Chang, L.-C., Huang, C.-H., Cheng, C.-H., Chen, B.-H., Chen, H.-C.* 2005 Differential effect of the focal adhesion kinase Y397F mutant on v-Src-stimulated cell invasion and tumor growth,J. Biomed. Sci.12. pp.571-585. (SCI)
 
32.Cheng, C.-H., Yu, K.-C., Chen, H.-L., Chen, S.-Y., Huang, C.-H., Chan, P.-C., Wung, C.-W., and Chen, H.-C.* 2004 Blockade of v-Src-stimulated tumor formation by the Src homolog 3 domain of Crk-associated substrate,FEBS Letters 557. pp.221-227. (SCI)
 
33.Chuang, K.-P, Huang, Y.-F, Hsu, Y.-L, Liu, H.-S, Chen, H.-C, and Shieh, C.-C.* 2004 Ligation of lymphocyte function-associated antigen-1 on monocytes decreases very late antigen-4-mediated adhesion through a reactive oxygen species dependent pathway,Blood 104. pp.4046-4053. (SCI)
 
34.Chan, P.-C., Chen, Y.-L., Cheng, C.-H., Yu, K.-C., Cary, L. A., Shu, K.-H., Ho, W. L., and Chen, H.-C.* 2003 Src phosphorylates Grb2-associated binder 1 upon hepatocyte growth factor stimulation,Journal of Biological Chemistry 278. pp.44075-44082. (SCI)
 
35.Chan, P.-C., Liang, C.-C., Yu, K.-C., Chang, M.-C., Ho, W. L., and Chen, H.-C.* 2002 Synergistic effect of focal adhesion kinase overexpression and hepatocyte growth factor stimulation on cell transformation,Journal of Biological Chemistry 277. pp.50373-50379. (SCI)
 
36.Chen, B.-H., Tzen, J. T. C., Bresnick, A.R., and Chen, H.-C.* 2002 Roles of Rho-associated kinase and myosin light chain kinase in morphological and migratory defects of focal adhesion kinase-null cells,Journal of Biological Chemistry 277. pp.33857-33863. (SCI)
 
37.Cheng, C.-H., Hsieh, C.-L., Shu, K.-H., Chen, Y.-L., and Chen, H.-C.* 2002 Effect of calcium channel antagonist diltiazem and calcium ionophore A23187 on cyclosporine A-induced apoptosis of renal tubular cells,FEBS Letters 516. pp.191-196. (SCI)
 
38.Liang, C.-C., and Chen, H.-C.* 2001 Sustained activation of extracellular signal-regulated kinase stimulated by hepatocyte growth factor leads to integrin alpha2 expression that is involved in cell scattering,Journal of Biological Chemistry 276. pp.21146-21152. (SCI)
 
39.Jiang, S.-T., Chiu, S.-J., Chen, H.-C., Chuang, W.-J., and Tang, M.-J.* 2001 The role of alpha3 beta1 integrin in tubulogenesis of MDCK cells,Kidney International 59. pp.1770-1778. (SCI)
 
40.Lai, J.-F., Kao, S.-C., Jiang, S.-T., Tang, M.-J., Chan, P.-C., and Chen, H.-C.* 2000 Involvement of focal adhesion kinase in hepatocyte growth factor-induced scatter of Madin-Darby canine kidney cells,Journal of Biological Chemistry 275. pp.7474-7480.
 
41.Cheng, C.-H.*, Chen, H.-C., Shu, K.-H., Chen, C.-H., Wu, M.-J. and Lian, J.-D. 2000 Increase of hepatocyte growth factor after renal transplantation,Transplantation Proceedings 32. pp.2070-2072. (SCI)
 
42.Chan, P.-C., Lai, J.-F., Cheng, C.-H., Tang, M.-J., Chiu, C.-C., and Chen, H.-C.* 1999 Suppression of ultraviolet irradiation-induced apoptosis by overexpression of focal adhesion kinase in Madin-Darby canine kidney cells,Journal of Biological Chemistry 274. (SCI)
 
43.Reiske, H. R., Kao, S.-C., Cary, L.A., Guan, J.-L., Lai, J.-F., and Chen, H.-C.* 1999 Requirement of phosphatidylinositol 3-kinase in focal adhesion kinase-promoted cell migration, Journal of Biological Chemistry 274. pp.12361-12366. (SCI)
 
44.Chen, H.-C.*, Chan P.-C, Tang M.-J, Cheng C.-H, and Chang T.-J. 1998 Tyrosine phosphorylation of focal adhesion kinase stimulated by hepatocyte growth factor leads to mitogen-activated protein kinase activation,Journal of Biological Chemistry 273. pp.25777-25782. (SCI)
 
45.Chen, H.-C., Appeddu, P. A., Isoda, H. and Guan, J.-L. 1996 Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinase,Journal of Biological Chemistry 271. (SCI)
 
46.Chen, H.-C. and Guan, J.-L. 1996 The association of focal adhesion kinase with a 200-kDa protein that is tyrosine phosphorylated in response to platelet-derived growth factor,European Journal of Biochemistry 235. pp. 495-500. (SCI)
 
47.Guan J.-L, and Chen, H.-C. 1996 Signal transduction in cell-matrix interactions,International Review of Cytology 168. pp.81-108. (SCI)
 
48.Chen, H.-C., Appeddu, P. A., Parsons, J. T., Hildebrand, J. D., Schaller, M. D., and Guan, J.-L. 1995 Interaction of focal adhesion kinase with cytoskeletal protein talin, Journal of Biological Chemistry 270:. pp.16995-16999. (SCI)
 
49.Chen, H.-C. and Guan, J.-L. 1994 Stimulation of phosphatidylinositol 3-kinase association with focal adhesion kinase by platelet-derived growth factor, Journal of Biological Chemistry 269. pp.31229-31233. (SCI)
 
50.Chen, H.-C. and Guan, J.-L. 1994 Association of focal adhesion kinase with its potential substrate phosphatidylinositol 3-kinase,Proceedings of the National Academy of Sciences USA. 91. pp.10148-10152. (SCI)
 
51.Xing, Z., Chen, H.-C., Nowlen, J. K., Taylor, S., Shalloway, D., and Guan, J.-L. 1994 Direct interaction of v-src with the focal adhesion kinase mediated by the src SH2 domain, Molecular Biology of the Cell 5. pp.413-421. (SCI)
B.研討會論文
 
1.Chen, T.-H , Chan, P.-C, Chen, C.-L and Chen, H.-C. 2010/03 Phosphorylation of Focal Adhesion Kinase on Tyrosine 194 by Met Leads to Its Activation through Relief of Autoinhibition,The 25th Joint Annual Conference of Biomedical Science. Taipei,Taiwan.March 27~28.
 
2.Chen, C.-L and Chen, H.-C. 2010/01 Functional Suppression of E-cadherin by Protein Kinase Cδ,The 18th Symposium on Recent Advances in Cellular and Molecular Biology, Kenting,. Taiwan, January .
 
3.Chan, P.-C, Sudhakar, J.-N, Lai, C.-C and Chen, H.-C. 2010/01 Differential Phosphorylation of the Docking Protein Gab1 by c-Src and the Hepatocyte Growth Factor Receptor Regulates Different Aspects of Cell Functions,The 18th Symposium on Recent Advances in Cellular and Molecular Biology. Kenting, Taiwan, January 20~22.
 
4.Pan, Y.-R and Chen, H.-C. 2010/01 Focal Adhesion Kinase is Essential for Podosome Rosette Assembly, but Dispensable for Individual Podosome Formation, The 18th Symposium on Recent Advances in Cellular and Molecular Biology. Kenting, Taiwan, January 20~22.
 
5.Chen, T.-H and Chen, H.-C. 2010/01 Phosphorylation of Focal Adhesion Kinase on Tyrosine 194 by Met Leads to Its Activation,The 18th Symposium on Recent Advances in Cellular and Molecular Biology, Kenting. Taiwan, January 20~22.
 
6.Lin, Y.-P and Chen, H.-C. 2010/01 Loss of Cell-cell Adhesions Induces Translocation of α-adducin into the Nucleus: a Role of α-adducin in Cell Proliferation,The 18th Symposium on Recent Advances in Cellular and Molecular Biology. Kenting, Taiwan, January 20~22 .
 
7.Chen, C.-L and Chen, H.-C. 2009 Functional suppression of E-cadherin by protein kinase Cdelta,前瞻性生物醫學暨科學新知研討會. (SCI)
 
8.Chen, H.-C. 2007/07 Phosphorylation of adducing by protein kinase C delta promotes cell motility,The 32nd FEBS Congress. Vienna, Austria, July 7-12, pp.132.
 
9.Chen, S.-Y. and Chen, H.-C.* 2007/05 Direct interaction of FAK with MET is required for FAK to promote hepatocyte growth factor-induced cell invasion,NHRI Conference on Cell Signaling and Developmental Biology. pp.14.
 
10.Chen, C.-L. and Chen, H.-C. 2007/02 Role of protein kinase C delta in cell motility,The 15th Symposium on Recent Advances in Cellular and Molecular Biology, Kenting, . Taiwan, February 1-3.
 
11.Chen, S.-Y. and Chen, H.-C. 2007 Direct interaction of FAK with MET is required for FAK to promote hepatocyte growth factor-induced cell invasion,The 22th Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan, March 17-18, pp.198.
 
12.Chen, C.-L. and Chen, H.-C. 2007 Role of protein kinase C delta in cell motility,The 22th Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan, March , pp.150 .
 
13.Chen, S.-Y. and Chen, H.-C. 2007 Direct interaction of FAK with MET is required for FAK to promote hepatocyte growth factor-induced cell invasion, The 15th Symposium on Recent Advances in Cellular and Molecular Biology, Kenting. Taiwan, February 1-3, pp.61.
 
14.Chen, H.-C. 2006/09 Direct interaction of FAK with MET is required for FAK to promote hepatocyte growth factor-induced cell invasion,European Biomarker Summit. Prague. Czech Republic, Sep. 26-27.
 
15.Chen, H.-C. 2006/09 Direct interaction of FAK with MET is required for FAK to promote hepatocyte growth factor-induced cell invasion,RNAi Europe. Prague, Czech Republic. Sep. 28-29.
 
16.Chen, H.-C.* 2006 Direct Interaction between focal adhesion kinase wand hepatocyte growth factor receptor,Tainan, Taiwan. November 25-26, pp.14.
 
17.Chen, H.-C.* 2006 Direct interaction between focal adhesion kinase and hepatocyte growth factor receptor,International Symposium on Cell signaling and Gene Regulation. Tainan, Taiwan, Nov. 25-26, pp.14.
 
18.Chang, L.-C. and Chen, H.-C. 2005/02 Effect of focal adhesion kinase Y397F mutant on v-Src-induced transforamtion,The 13th Symposium on Recent Advances in Cellular and Molecular Biology, Kenting. Taiwan, February 26-28.
 
19.Chen, H.-C.* 2005 Interaction of focal adhesion kinase with hepatocyte growth factor receptor, Symposium on Genomics Medicine Signal Transduction. Taipei, Taiwan. Nov. 4-5, pp.36.
 
20.Chung, M.-C. and Chen, H.-C. 2005 Activation of Src by Ras,The 13th Symposium on Recent Advances in Cellular and Molecular Biology, Kenting. Taiwan, February 26-28, pp.106.
 
21.Chan, P.-C.,* Chen, Y.-L., and Chen, H.-C. 2004/02 Src phosphorylates Grb2-associated binder 1 upon hepatocyte growth factor stimulation,The 12th Symposium on Recent Advances in Cellular and Molecular Biology, Kenting. Taiwan, February 2-4, pp.49.
 
22.Chen, S.-Y. and Chen, H.-C. 2004 Interaction of focal adhesion kinase with oncogene Tpr-Met.,The 12th Symposium on Recent Advances in Cellular and Molecular Biology, Kenting. Taiwan, February 2-4, , pp.103.
 
23.Chen, C.-L. and Chen, H.-C. 2004 Involvement of protein kinase C in hepatocyte growth factor signaling,The 12th Symposium on Recent Advances in Cellular and Molecular biology, Kenting. Taiwan, February 2-4, pp.102 .
 
24.Chen, H.-C.* 2004 Involvement of protein kinase C delta in hepatocyte growth factor signaling,Mini-symposium on Cell signaling and Gene expression. Tainan, Taiwan, November 24.
 
25.Chen, H.-C.* 2003 Role of Src in hepatocyte growth factor-stimulated Gab1 phosphorylation,The 3rd Fall Camp of Taiwan Society for Biochemistry and Molecular Biology. Tainan, Taiwan. November 14-16, pp.35.
 
26.Chen, H.-C.* 2003 Involvement of protein kinase C delta in hepatocyte growth factor signaling,International Symposium on Cell signaling and Gene expression. Tainan, Taiwan, October 22, pp.9.
 
27.Chen, B.-H.* and Chen, H.-C. 2003 Roles of Rho-associated kinase and myosin light chain kinase in morphological and migratory defects of focal adhesion kinase-null cells,The 11th Symposium on Recent Advances in Cellular and Molecular Biology, Kenting. Taiwan, January 20-22, pp.42.
 
28.Chan, P.-C.* and Chen, H.-C. 2003 Synergistic effect of focal adhesion kinase overexpression and hepatocyte growth factor stimulation on cell transformation,The 11th Symposium on Recent Advances in Cellular and Molecular Biology, Kenting. Taiwan, January 20-22, pp.40.
 
29.Chen, H.-C.* 2003 Roles of Rho-associated kinase and myosin light chain kinase in morphological and migratory defects of focal adhesion kinase-null cells,The 4th East Asia Biophysics Symposium. Taipei, Taiwan, November 3-6, pp.55.
 
30.Chen, Y.-L. and Chen, H.-C. 2002/03 Role of Src in hepatocyte growth factor-mediated Gab-1 phosphorylation,The 17th Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan, March 23-24, pp.159.
 
31.Hsieh, C.-L. and Chen, H.-C. 2002 Effect of calcium channel antagonist diltiazem and calcium ionophore A23187 on cyclosporine A-induced apoptosis of renal tubular cells, The 17th Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan, March 23-24.
 
32.Chen, H.-C. 2002 Role of integrins and focal adhesion kinase in cell transformation induced by latent membrane protein 1 of Epstein-Bar virus,The 10th International Symposium on Epstein-Bar Virus and Associated Malignant Diseases. Cairns, Australia, July 16-21, pp.163.
 
33.Chen, H.-C.* 2002 Roles of Rho-associated kinase and myosin light chain kinase in morphological and migratory defects of focal adhesion kinase-null cells,International Symposium on Tissue Remodeling: Growth, Apoptosis, and Differentiation. Tainan, Taiwan, October 21-22, pp.12 .
 
34.Chen, H.-C.* 2002 Role of focal adhesion kinase in hepatocyte growth factor signaling,The 10th Symposium on Recent Advances in Cellular and Molecular biology, Kenting. Taiwan, January 25-28, pp.20.
 
35.Chen, H.-C.* 2001 Elevated expression of focal adhesion kinase renders epithelial cells susceptible to transformation by hepatocyte growth factor,The 16th Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan, March 24-25, pp.68 .
 
36.Chen, H.-C.* 2001 Elevated expression of focal adhesion kinase renders epithelial cells susceptible to transformation by hepatocyte growth factor.,The 1st NHRI Conference on Signal Transduction. Tao-Yuan, Taiwan, February 9-10, pp.19 .
 
37.Liang, C.-C. and Chen, H.-C. 2001 Sustained activation of extracellular signal-regulated kinase is required for hepatocyte growth factor-induced integrin alpha2 expression and cell scattering,The 9th Symposium on Recent Advances in Cellular and Molecular Biology, Kenting. Taiwan, February 3-5, pp.76 .
 
38.Chen, B.-H. and Chen, H.-C. 2001 Suppression of myosin light kinase activity by focal adhesion kinase., The 9th Symposium on Recent Advances in Cellular and Molecular Biology, Kenting. Taiwan, February 3-5, pp.75.
 
39.Chen, H.-C.* 2001 Role of focal adhesion kinase in hepatocyte growth factor signaling,Symposium on Cell Signaling and Gene Expression. Kobe, Japan, November 26-27, pp.4.
 
40.Chan, P.-C, Liang, C.-C., and Chen, H.-C. 2001 Elevated expression of focal adhesion kinase renders epithelial cells susceptible to transformation by hepatocyte growth factor,The 9th SCBA International Symposium, Academia Sinica. Taipei, August 5-10, pp.414.
 
41.Chan, P.-C and Chen, H.-C. 2000 Suppression of UV-induced apoptosis by overexpression of focal adhesion kinase in MDCK cells,The 8th Symposium on Recent Advances in Cellular and Molecular Biology, Kenting. Taiwan, January 29-31, pp.72 .
E.技術報告
 
1.Chen, H.-C. 2005 Cell Scatter Assay,In Cell Migration: Developmental Methods and Protocols. pp.69-78.
 
2.Chen, H.-C. 2005 Boyden Chamber Assay,In Cell Migration: Developmental Methods and Protocols. pp.15-22.