李龍緣[ 副教授 ]

辦公室電話: 04-22840416#602
實驗室電話: 04-22840416#603
傳      真 :
實驗室位置: 生命科學大樓602室
最 高 學 歷 : 台大醫學院微生物所博士
專 長 領 域 : 癌症生物學、幹細胞生物學、分子細胞生物學 
電 子 信 箱 : lyuan@dragon.nchu.edu.tw
實驗室網站:  
 
年份 標題
2012 行政院國家科學委員會吳大猷先生紀念獎
2011 中國醫藥大學系所績優導師
2010 中國醫藥大學醫學院教學優良教師獎
2006 美國癌症研究學會 Scholar-in-Training Award
2006 美國安德森癌症中心 Trainee Excellence Award
2002 台大醫學院博士班研究生傑出著作獎
2002 第 10 屆細胞及分子生物新知研討會徐千田優秀論文獎
1995 台灣微生物學會嚴智鍾教授獎學金
1995 劉瑞恆先生紀念獎學金
1992 林公熊徵學田獎學金
 
 
 
癌症訊息傳遞及表觀基因調控、幹細胞分化調控、新藥/新療法研發
 
 
A.期刊論文
 
1.Y-H. Chen, Y-C Liu, C-J Chung, S-P Yeh, J Hsu, M-C Hung, H-L Su and L-Y Li*. 2016/08 EZH2 and HDAC9c regulate age-dependent mesenchymal stem cell differentiation into osteoblasts and adipocytes., Stem Cells . (SCI)
 
2.Li, C-W., Xia, W., Lim, S-O., Hsu, Jennifer L., Huo, L., Wu, Y., Li, L-Y., Lai, C-C.,Chang, S-S., Hsu, Y-H., Sun, H-L., Kim, J., Yamaguchi, H., Lee, D-F., Wang, H., Wang, Y., Chou 2016/03 AKT1 Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer through Phosphorylation-Dependent Twist1 Degradation., Cancer Research, . vol.76, pp.1451-1462,. (SCI)
 
3.P-H Lin, W-H Kuo, A-C Huang, Y-S Lu, C-H Lin, S-H Kuo, M-Y Wang, C-Y Liu, F T-F Cheng, M-H Yeh, H-Y Li, Y-H Yang, Y-H Hsu, S-C Fan, L-Y Li, S-L Yu, K-J Chang,P-L Chen, Y-H Ni, C-S Huang. 2016/02 Multiple gene sequencing for risk assessment in patients with early-onset or familial breast cancer, Oncotarget, . vol.7, pp.8310-8320. (SCI)
 
4.Ko HW, Lee HH, Huo L, Xia W, Yang CC, Hsu JL, Li LY, Lai CC, Chan LC, Cheng CC, Labaff AM, Liao HW, Lim SO, Li CW, Wei Y, Nie L, Yamaguchi H, Hung MC 2016 GSK3β inactivation promotes the oncogenic functions of EZH2 and enhances methylation of H3K27 in human breast cancers,Oncotarget. vol.7, pp.57131-57144. (SCI)
 
5. Dai, H-Y., Chen, H-Y., Lai, W-J., Hung, M-C., Li, L-Y.* 2015/09 Targeted expression of BikDD combined with metronomic doxorubicin induces synergistic antitumor effect through Bax activation in hepatocellular carcinoma.,Oncotarget,. vol.6, pp.23807-23819. (SCI)
 
6.Yang, C-C., Labaff, A., Wei, Y., Nie, L., Xia, W., Huo, L., Yamaguchi, H., Hsu, Y-H., Hsu, J. L., Liu, D., Lang, J., Du, Y., Lien, H-C., Li, L-Y., Deng, R., Chan, L-C., Yao, J.,Kleer, C. G., Hortobag 2015 Phosphorylation of ezh2 at t416 by cdk2 contributes to the malignancy of triple negative breast cancers. , Am J Transl Res . vol.7, pp.1009-1020. (SCI)
 
7.Lein, M-Y., Liu, L-C., Wang, H-C., Yeh, M-H., Chen, C-J., Yeh, S-P., Bai, L-Y., Liao, Y-M., Lin, C-Y., Hsieh, C-Y., Lin, C-C., Li, L-Y., Lin, P-H., Chiu, C-F. 2014 Safety and Efficacy of Pegylated Liposomal Doxorubicin-based Adjuvant Chemotherapy in Patients with Stage I-III Triple-negative Breast Cancer , Anticancer Res.. vol.34, pp.7319-7326. (SCI)
 
8.Su, C-H., Hsiao, C-L., Chang, W-S., Liu, L-C., Wang, H-C., Tsai, C-W., Li, L-Y., Tsai, C-H., Bau, D-T. 2014 Evaluation of the contribution of cyclooxygenase 2 genotypes to breast cancer in Taiwan, Anticancer Res.. vol.34, pp.6711-6716. (SCI)
 
9.. Liu, Y-C., Kao, Y-T., Huang, W-K., Lin, K-Y., Wu, S-C., Hsu, S-C., Schuyler, S-C., Li,L-Y., Lu, L. F., Lu, J. 2014 CCL5/RANTES is important for inducing osteogenesis of human mesenchymal stem cells and is regulated by dexamethasone. ,Biosci Trends. . vol.8, pp.138-143. (SCI)
 
10.Chang, T-Y., Chung, C-Y., Chuang, W-M., Li, L-Y., Jeng, L-B. and Ma, W-L. 2014 Durable Expression of Minicircle DNA-Liposome-delivered Androgen Receptor cDNA in Micewith Hepatocellular Carcinoma. , BioMed Research International. vol.9, pp. 156356. (SCI)
 
11. Huo, L., Li, C-W., Huang, T-H., Lam, Y. C., Xia, W., Tu, C., Chang, W-C., Hsu, J. L., LeeD-F., Nie, L., Yamaguchi, H., Wang, Y., Lang, J., Li, L-Y., Chen, C-H., Mishra, L. and,Hung, M-C. 2014 Activation of Keap1/Nrf2 signaling pathway by nuclear epidermal growth factor receptor in cancer cells,Am J Transl Res. vol.6, pp.649-663. (SCI)
 
12.Chou, R-H., Wang, Y-N., Hsieh, Y-H., Li, L-Y., Xia, W., Chang, W-C., Chang, L-C., Cheng, C-C., Lai, C-C., Hsu, J. L., Chang, W-J., Chiang, S-Y., Lee, H-J., Liao, H-W.,Chuan 2014 EGFR modulates DNA synthesis and repairs through Tyr phosphorylation of Histone H4. ,Dev Cell . vol.30, pp.224-237. (SCI)
 
13.Li, L-Y.*. 2014 EZH2: novel therapeutic target for human cancer. , BioMedicine,. vol.4, pp.1-6. (SCI)
 
14. Chang, W-S., Lin, S-S., Li, F-J., Tsai, C-W., Li, L-Y., Lien, C-S., Liao, W-L., Wu, H-C.Tsai, C-H., Shih, T-C., Bau, D-T. , 2013 Significant Association of Caveolin-1 (CAV1) Genotypes with Upper Urothelial Tract Cancer. ,Anticancer Res. . vol.33, pp.4907-4912. (SCI)
 
15.. Lin, P-H., Lin, C-C., Yang, H-I., Li, L-Y., Bai, L-Y., Chiu, C-F., Liao, Y-M., Lin, C-Y.,Hsieh, C-Y., Lin, C-Y., Ho, C-M., Yang, S-F., Peng, C-T., Tsai, F-J., Yeh, S-P. 2013 Prognostic impact of allogeneic hematopoietic stem cell transplantation for acute myeloid leukemiapatients with internal tandem duplication of FLT3. ,Leukemia Research,. vol.37, pp. 287-292. (SCI)
 
16. Lin, P-H., Yeh, M-H., Liu, L-C., Chen, C-J., Tsui, Y-C., Su, C-H., Wang, H-C., Liang, J-A., Chang, H-W., Wu, H-S., *Li, L-Y. and Chiu, C-F. 2013 Clinical and pathologic risk factors of tumor recurrence in patients with node-negative early breast cancer after mastectomy. ,Journal of Surgical Oncology,. vol.108, pp.352-7. (SCI)
 
17. Chen, Y-H., Hung, M-C. and Li, L-Y.*. 2012 EZH2: a pivotal regulator in controlling cell differentiation., Am J Transl Res . vol.4, pp.364-375. (SCI)
 
18.. Liu, M., Lee, D-F., Chen, C-T., Yen, C-J., Li, L-Y.*, Lee, H-J., Chang, C-J., Chang, W-C.,Hsu, J-M., Kuo, H-P., Xia, W., Wei, Y., Chiu, P-C., Chou, C-K., Du, Y., Dhar, D., Karin,M., Chen, C-H. 2012 IKKα activation of NOTCH links tumorigenesis via FOXA2 suppression., Molecular Cell. vol.45, pp.171-184. (SCI)
 
19. Song, H., Li, C-W., LaBaff, A. M., Lim, S-O., Li, L-Y., Kan, S-F., Chen, Y., Zhang, K., Lang, J-Y., Xie, X., Wang, Y., Huo, L-F., Hsu, S-C., Chen, X-M., Zhao, Y-M. and HungM-C. , 2011 Acetylation of EGF receptor contributes to tumor cell resistance to histone deacetylase inhibitors., Biochem. Biophys. Res. Commun.. vol.404, pp.68-73. (SCI)
 
20. Hsu, J-M., Chen, C-T., Chou, C-K., Kuo, H-P., Li, L-Y., Lin, C-Y., Lee, H-J., WangY-N., Liu, M., Liao, H-W., Shi, B., Lai, C-C., Bedford, M. T., Tsai, C-H. and Hung, M-C. , 2011 Crosstalk between Arg1175 methylation and Tyr1173 phosphorylation negatively modulates EGFR-mediated ERK activation., Nature Cell Biology . vol.13, pp.174-181. (SCI)
 
21. Sher, Y-P, Liu, S-J., Chang, C-M., Lien, S-P., Chen, C-H., Han, Z., Li, L-Y., Chen, J-S.,Wu, C-W. and Hung, M-C. 2011 Cancer-targeted gene therapy elicits protective anti-tumor immunity against lung cancer. , Mol Cancer Ther . vol.10, pp.637-647. (SCI)
 
22. Huang, W-C., Chen, Y-J., Li, L-Y., Wei, Y-L., Hsu, S-C., Tsai, S-L., Chiu, P-C., Huang,W-P., Wang, Y-N., Chen, C-H., Chang, W-C., Chang, W-C., Chen, A. J-E., Tsai, C-H.Hung, M-C., 2011 Nuclear translocation of EGFR by AKT-dependent phosphorylation enhances BCRP/ABCG2 expression in gefitinib-resistant cells.,Journal of Biological Chemistry . vol.286, pp.:20558-20568. (SCI)
 
23.Cai, C., Li, H., Yen, C-J., Kuo, H-P., Lee, D-F., Lang, J., Huo, L., Cheng, X., Chen, Y-J.,Li, C-W., Jeng, L-B., Hsu, J. L., Li, L-Y., Tan, A., Curley, S. A., Ellis, L. M., Dubois, R. N. 2011 APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis., J Clin Invest.. vol.121, pp.4526-4536. (SCI)
 
24. Wei, Y., Chen, Y-H., Li, L-Y.*, Lang, J., Yeh, S-P., Shi, B., Yang, C-C., Yang, J-Y., Lin,C-Y., Lai, C-C. and Hung, M-C. 2011 CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymalstem cells. ,Nature Cell Biology. vol.13, pp.87-94. (SCI)
 
25. Chen, Y-H., Yeh, F-L., Yeh, S-P., Ma, H-T., Hung, S-C., Hung, M-C. and Li, L-Y.* 2011 MITR is a switch that promotes osteogenesis and inhibits adipogenesis of mesenchymal stemcells by inactivating PPARγ-2. ,Journal of Biological Chemistry. vol.286, pp.10671-10680. (SCI)
 
26. Li, L-Y.*, Dai, H-Y., Yeh, F-L., Kan, S-F., Lang, J-Y., Hsu, J-L., Jeng, L-B., Chen, Y-H., Sher, Y-P., Lin, W-C. and Hung, M-C. 2011 Targeted hepatocellular carcinoma proapoptic BikDD gene therapy.,Oncogene. vol.30, pp.1773-83. (SCI)
 
27. Li, L-Y*, Chen, H., Hsieh, Y-H., Wang, Y-N., Chu, H-J., Chen, Y-H., Chen, H-Y., Chien,P-J., Ma, H-T., Tsai, H-C., Lai, C-C., Sher, Y-P., Lien, H-C., Tsai, C-H. and Hung, M-C. 2011 Nuclear ErbB-2 enhances translation and cell growth by activation of rRNA gene transcription., Cancer Research . vol.71, pp.4269-4279. (SCI)
 
28.Guven, E. O., Chen, Y-H., Li, L-Y., Hsu, M-C., Coleman, R. L., Calin, G. A., Denkbas, E.B., Lim, J. Y., Lee, J-S., Kundra, V., Birrer, M. J., Hung, M-C., Lopez-Berestein, G. andSood, A. K. 2010 Regulation of tumor angiogenesis by EZH2., Cancer Cell . vol.18, pp.185-197. (SCI)
 
29. Huo, L., Wang, Y-N., Xia, W., Hsu, S-C., Lai, C-C., Li, L-Y., Chang, W-C., Wang, Y., Hsu, M-C, Yu, Y-L., Huang, T-H, Ding, Q., Chen, C-H., Tsai, C-H. and Hung, M-C. 2010 RNA helicase A is a DNA-binding partner for EGFR-mediated transcriptional activation in the nucleus. ,PNAS. vol.107, pp.16125-16130. (SCI)
 
30. Chou, C-K., Lee, D-F., Sun, H-L., Li, L-Y., Lin, C-Y., Huang, W-C., Hsu, J-M., Kuo, H-P.,Yamaguchi, H., Wang, Y-N., Liu, M., Wu, H-Y., Liao, P-C., Yen, C-J. and Hung, M-C. 2009 The suppression of MAD1 by AKT-Mediated phosphorylation activates MAD1 target genes transcription , Mol Carcinog. vol.48, pp.1048-1058,. (SCI)
 
31. Kuo, H-P., Lee, D-F., Xia, W., Lai, C-C., Li, L-Y. and Hung, M-C. 2009 Phosphorylation of ARD1 by IKK beta contributes to its destabilization and degradation., Biochem. Biophys. Res. Commun.. vol.389, pp.156-161. (SCI)
 
32. Lee, D-F., Kuo, H-P., Liu, M., Chou, C-K., Xia, W., Du, Y., Shen, J., Chen, C-T., Huo,L., Hsu. M-C., Li, C-W., Ding, Q., Liao, T-L., Lai, C-C., Lin, A-C., Chang, Y-H., Tsai, S-F., Li, L-Y. and Hung, 2009 KEAP1 E3 ligase-mediated downregulation of NF-κB signaling by targeting IKKβ.,Molecular Cell . vol.36, pp.131-140. (SCI)
 
33.Sher, Y-P., Tzeng, T-F., Kan, S-F., Hsu, J., Xie, X., Han, Z., Lin, W-C., Li, L-Y.* and Hung, M-C. 2009 Cancer targeted gene therapy of BikDD inhibits orthotopic lung cancer growth and improves long-term survival. , Oncogene . vol.28, pp.3286-3295. (SCI)
 
34. Yang, J-Y., Zong, C. S., Xia, W., Yamaguchi, H., Ding, Q., Xie, X., Lang, J-Y., Lai, C-C., Chang, C-J., Huang, W-C., Huang, H., Kuo, H-P., Lee, D-F., Li, L-Y., Lien, H-C., Cheng,X., Chang, K-J., Hsi 2008 ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation. ,Nature Cell Biology . vol.10, pp.138-148. (SCI)
 
35. Ding, Q., Huo, L., Yang, J-Y., Xia, W., Wei, Y., Liao, Y., Chang, C-J., Yang, Y., Lai, C-C.,Lee, D-F., Yen, C-J., Chen, Y-J., Hsu, J-M., Kuo, H-P., Lin, C-Y., Tsai, F-J., Li, L-Y., TsaiC-H. 2008 Down-regulation of myeloid cell leukenia-1 through inhibiting Erk/Pin 1 pathway by Sorafenib facilitates chemosensitization in breast cancer , Cancer Research . vol.68, pp.:6109-6117. (SCI)
 
36.. Ding, Q., He, X., Hsu, J-M., Xia, W., Chen, C-T., Li, L-Y., Lee, D-F., Liu, J-C., Zhong, Q.,Wang, X. and Hung, M-C. 2007 Degradation of Mcl-1 by β-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization. , Molecular and Cellular Biology . vol.27, pp.4006-4017. (SCI)
 
37. Ding, Q., He, X., Xia, W., Hsu, J-M., Chen, C-T., Li, L-Y., Lee, D-F., Yang, J-Y., Xie, X.,Liu, J-C. and Hung, M-C. 2007 Myeloid cell leukemia-1 inversely correlates with glycogen synthase kinase-3β activity and associates with poor prognosis in human breast cancer. ,Cancer Research . vol.67, pp.4564-4571. (SCI)
 
38.. Lee, D-F., Kuo, H-P., Chen, C-T., Hsu, J-M., Chou, C-K., Wei, Y., Sun, H-L., Li, L-Y., Ping, B., Huang, W-C., He, X., Hung, J-Y., Lai, C-C., Ding, Q., Su, J-L., Yang, J-Y., Sahin,A. A., 2007 Hortobagyi, G. N., Tsai, F-J., Tsai, C-H. and Hung, M-C. IKKβ suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR Pathway. ,Cell . vol.130, pp.440-455. (SCI)
 
39.. Li, L-Y., Liu, M-Y., Shih, H-M., Tsai, C-H. and Chen, J-Y. 2006 Human cellular protein VRK2 specifically interacts with Epstein-Barr virus BHRF1, a homologue of Bcl-2, and enhancescell survival. ,J. Gen. Virol.. vol.87, pp.2869-2878. (SCI)
 
40.. Wang, S-C., Nakajima, Y., Yu, Y-L., Xia, W., Chen, C-T., Yang, C-C., McIntush, E. W., LiL-Y., Hawke, D. H., Kobayashi, R. and Hung, M-C. 2006 Tyrosine phosphorylation controls , PCNA function through protein stability. ,Nature Cell Biology . vol.8, pp.1359-1368. (SCI)
 
41. Giri, D. K. ¥ , Ali-Seyed, M. ¥ , Li, L. Y. ¥ (co-first author), Lee, D. F., Ling, P.Bartholomeusz G., Wang, S. C. and Hung, M. C.. 2005 Endosomal transport of ErbB-2:mechanism for nuclear entry of the cell surface receptor. ,Mol. Cell. Biol. vol.25, pp.11005-11018. (SCI)
 
42.. Chou, S. P., Tsai, C. H., Li, L. Y., Liu, M. Y., and Chen, J. Y.. 2004 Characterization of a novel monoclonal antibody to the BHRF1 protein of Epstein-Barr virus. ,Hybrid Hybridomics. . vol.23, pp.29-37. (SCI)
 
43.. Li, L. Y., Shih, H. M., Liu, M. Y., and Chen, J. Y.. 2001 The cellular protein PRA1 modulates the anti-apoptotic activity of Epstein-Barr virus BHRF1, a homologue of Bcl-2, throughdirect interaction. , J. Biol. Chem.. vol.276, pp. 27354-27362. (SCI)
 
44.. Liu, M. Y., Shih, Y. Y., Li, L. Y., Chou, S. P., Sheen, T. S., Chen, C. L., Yang, C. S., and Chen, J. Y.. 2000 Expression of the Epstein-Barr virus BHRF1 gene, a homologue of Bcl-2, in nasopharyngeal carcinoma tissue, J. Med. Virol. vol.61, pp. 241-250. (SCI)
 
45. Chen, S. L., Lin, Y. K., Li, L. Y., Tsao, Y. P., Lo, H. Y., Wang, W. B., and Tsai, T. C.. 1996 E5 proteins of human papillomavirus types 11 and 16 transactivate the c-fos promoter through the NF1 binding element., J. Virol. . vol.70, pp. 8558-8563. (SCI)
 
46. Tsao, Y. P., Li, L. Y., Tsai, T. C., and Chen, S. L.. 1996 Human papillomavirus type 11 and 16 E5 represses p21 (WafI/SdiI/CipI) gene expression in fibroblasts and keratinocytes., J. Virol. . vol.70, pp.7535-7539. (SCI)
 
47. Tsao, Y. P., Kuo, S. W., Li, S. F., Tsai, T. C., Li, L. Y., and Chen, S. L.. 1995 Human papillomavirus 11 E5a delays the growth restriction induced by temperature shift intemperature-sensitive simian virus 40 T antigen-immortalized keratinocytes ,Biochem. Biophys. Res. Commun. . vol.217, pp.712-720. (SCI)