劉英明[ 教授 ]

肌肉生理生化研究室
辦公室電話: (04) 22840416 # 717
實驗室電話: (04) 22840416 # 718
傳   真:
實驗室位置: 生命科學大樓 716 室
最高學歷: 美國匹茲堡大學生理學博士
專長領域: 肌肉蛋白,生物物理,細胞分子生理,分子馬達  
電子信箱: ymlion@dragon.nchu.edu.tw
實驗室網站:  
 
 
畢業學校 主修學門系所 學位 時期
美國匹茲堡大學 生理學 博士 1987/09 - 1992/04
國立台灣大學 動物學系 學士 1980/10 - 1984/06
 
服務機關 服務部門 職稱 時期
國立中興大學 生命科學系 教授 2005/08~迄今
國立中興大學 生命科學系 副教授 2002/08 - 2005/07
國立中興大學 動物學系 副教授 1994/08 - 2002/07
私立中山醫學大學 生理學系 副教授 1994/02 - 1994/07
美國哈佛大學 心血管研究部 博士後研究 1992/08 - 1994/01
 
研究興趣
1 臍帶幹細胞生長與分化
2 細胞骨骼以及肌肉細胞之分子馬達
3 建立研究心血管功能的實驗動物模式
4 造骨蛋白之生物功能

研究主題
1 臍帶wharton's jelly 幹細胞生長與分化之分子調控
2 細胞骨骼以及肌肉分子馬達之細胞運動功能的研究
3 建立研究心血管功能的實驗動物模式
4 肌肉蛋白分子調控鈣離子活化肌肉收縮的分子機轉

目前研究計畫
1 利用心肌傷害之實驗動物鼠來研究綠茶多酚保護心肌受損的機制探討 (NSC 98-2320-B-005-001-MY2)
 
博士班
廖娟妙, 陳建佑

碩士班
彭康維,許源彰,邱冠穎,許建生

大學部

研究助理

博士後研究

畢業生
 
A.期刊論文
 
1.Sy HN, Wu SL, Wang WF, Chen CH, Huang YT, Liou YM, Chiou CS, Pawlak CR, Ho YJ. 2010 MPTP-induced dopaminergic degeneration and deficits in object recognition in rats are accompanied by neuroinflammation in the hippocampus. ,Pharmacol Biochem Behav. (SCI)
 
2.Wang AL, *Liou Y-M (co-first author), Pawlak CR, Ho YJ 2010 Involvement of NMDA receptors in both MPTP-induced neuroinflammation and deficits in episodic-like memory in Wistar rats,BEHAV BRAIN RES (2009, in pressdoi:10.1016/j.bbr.2009.11.006). (SCI)
 
3.Shieh DB, Li RY, Liao JM, Chen GD, Liou YM*. 2009 Effects of Genistein on β-catenin Signaling and Subcellular Distribution of Actin-Binding Proteins in Human Umbilical CD105-Positive Stromal Cells,(2009, Accepted on 12/2/09) . (SCI)
 
4.Wang WF, Wu SL, Liou YM, Wang AL, Pawlak CR, Ho YJ 2009 MPTP lesion causes neuroinflammation and deficits in object recognition in Wistar rats,Behavioral Neuroscience.123. pp.1261-1270. (SCI)
 
5.*Liou YM, Hsieh SR, Wu TJ. 2009 Green tea and cardiac health,CAB Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources. 4. no.020, pp.TCVGH- NCHU 967602, TCVGH- NCH.
 
6.Shieh SR, Tsai DC, Chen JY, Tsai SW, * Liou YM 2009 Green tea extract protects rats against myocardial infarction associated with left anterior descending coronary artery ligation,Articles in PresS. Pflugers Archiv - European Journal of Physiology 458. pp.631-342. (SCI)
 
7.Liou YM, Watanabe M, Yumoto M, Ishiwata S 2009 Regulatory mechanism of smooth muscle contraction studied with gelsolin-treated strips of Taenia Caeci in Guinea Pig,Am J Physiol Cell Physiol 296. pp.C1024-C1033. (SCI)
 
8.Chang CP, Liu JC, Liou YM, Chang SS, Chen JY 2008 The role of false lumen size in prediction of in-hospital complications after acute type B aortic dissection,J Am Coll Cardiol. 52. pp.1170-1176. (SCI)
 
9.Tsai, SW, Wu, SK, Liou, YM, Shu SG 2008 Early development in Williams Syndrome. Pediatrics International,Pediatr Int. 50. pp.221-224. (SCI)
 
10.*Liou, YM, Kuo SC, Hsieh SR 2008 Differential effects of a green tea derived polyphenol (-)-epigallocatechin-3-gallate on the acidosis-induced decrease in the Ca2+ sensitivity of cardiac and skeletal muscle,Pflugers Archiv-EJP,456. pp.787-800. (SCI)
 
11.Ying-Ming Liou, H. Chao 2007 Fluorescence spectroscopic analysis of the proximity changes between the central helix of troponin C Biochimica et Biophysica Acta (BBA) ,Proteins & Proteomics 1174. pp.466-473 . (SCI)
 
12.Jiuan-Miaw Liao, Pei-Chen Huang, Shwu-Fen Pan, Mei-Jung Chen, Kwong-Chung Tung, Hsien-Yu Peng, Chih-Cheng Shih, Ying-Ming Liou, Gin-Den Chen, and Tzer-Bin Lin 2007 Spinal glutamatergic NMDA-dependent pelvic nerve-to-external urethra sphincter reflex potentiation c Am J Physiol (Renal Physiol) 292,pp.F1791-1801. (SCI)
 
13.J. Liao, H. Ting, S. Lee, C. Yang, Y. Liou, M. Peng, S. Tsai, C. Lin, T. Li 2006 Electroacupuncture-induced pressor and chronotropic effects in anesthetized rats,Autonomic Neuroscience,124. pp.18-25. (SCI)
 
14.*Liou Y.M., L.Y. Chang, J.M. Liaw, M.J. Jiang. 2005 Osteopontin Gene Expression in the Aorta and the Heart of Propylthiouracil-Induced Hypothyroid Mice Journal of Biomedical Science,vol.12, pp.869-880. (SCI)
 
15.*Liou, Y.M. and JCH Chang 2004 Differential pH Effect on Calcium-Induced Conformational Changes of Cardiac Troponin C Complexed wit J,Biochem 136 (5) . pp.683-692. (SCI)
 
16.Liou, Y.M. and M.W. Chen 2003 Calcium-Dependent Protein-Protein Interactions Induce Changes in Proximity Relationships of Cys-48 a Eur, J Biochem. 270. pp.2092-3100. (SCI)
 
17.*Liou, Y.M, YC Tseng, JC Cheng 2002 Spectrofluorometric Analysis of Length-Dependent Conformational Changes in Cardiac Troponin C. J. Muscle Res, Cell Molti.23. pp.309-315. (SCI)
 
18.Lung, F.T., C.H. Chen, H.Y. Chen, C.C. Liou, and Y.M. Liou 2002 Binding potency of peptide fragments of type 1 collagen cross-linked N-Telopeptide measured by an En Protein and Peptide Letters 9(5),pp.451-457. (SCI)
 
19.*Liou, Y.-M, MJ Jiang and MC Wu 2002 Changes in Thiol Reactivity and Extractability of Myofibril Bound Cardiac Troponin C in Porcine Mali J. Biochem,Tokyo 32(2). pp.317-325. (SCI)
 
20.*Liou, Y.M. 2001 Effects of Sarcomere length and Ca2+ Binding on SH reactivity of myofilament bound troponin C in por Jpn,J. Physiol. 51. pp.385-388. (SCI)
 
21.Liaw, R.-B., H.C. Chang, Y.Y. Lai, C.T. Liu, I.C. Lu, Y.M. Liou, and M.C. Wu. 2001 Porcine Strss Gene of Berkshire Breed Detected by MS-PCR and DNA Sequencing,J. Chin. Anim. Sci. 29.
 
22.*Liou, Y.-M, M.J. Jiang and M.C. Wu. 2000 Altered Expression of Cardiac Myosin Isozymes Associated with the Malignant Hyperthermia Genotype in Anesthesiology 93,pp.1312-1319. (SCI)
B.研討會論文
 
1.*Tsai, DC, SR Shieh, JY Chen, SW Tsai, #YM Liou. 2008/03 A study in vivo with cardio-protection of green tea extracts on rat myocardial infarction induced by coronary ligation,The 23rd Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan, March 17-18, 2008. .
 
2.*Li, RY, #YM Liou, TH Ying, Gin-Den Chen, JM Liao, DB Shieh 2008 Involvement of formin-2 expression in tyrosine kinase related cell growth of undifferentiated cultured human umbilical stem cells,The 23rd Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan, March 17-18, 2008. .
 
3.#Liou, YM, Watanabe, M, Ishiwata, SI. 2007 Reconstitution of calcium-regulated thin filaments into gelsolin-treated skinned smooth muscle of Taenia Caeci in guinea pigs,The 22th Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan, March 17-18, 2007.
 
4.Liou, YM, *SC Kuo 2007 Protective effects of green tea polyphenols of catechin and epigallocatechin-3-gallate on acidic pH reduction of Ca2+ sensitivity of cardiac muscle contraction,The 22nd Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan, March 17-18, 2007.
 
5.#Liou, YM, *JS Chen 2006 Age-dependent decreases in the expression levels of mouse brain formin-2. ,The 21st Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan, March 18-19, 2006..
 
6.W.Y. Chao, Y.M. Liou#. 2005/03 Study of fluorescence spectroscopy with protein-protein interaction among recombinant chicken skeletal troponin T,troponin C and troponin I The 20th Annual Conferences of Biomedical Science. Taipei, Taiwan, Mar 26-27, 2005. .
 
7.Liou, YM, M Watanabe, and S Ishiwata 2005/02 Studies with reconstitution of actin filaments into gelsolin-treated skinned smooth muscle strips of 49th American Biophysical Annual Meeting at Long Beach,CA, USA. , Feb 12-16..
 
8.*#Liou, YM, HL Chao. 2005 Effect of calcium and troponin I on the proximity relationship between the central helix of troponin C and the C-terminal end of troponin T,International Symposium Celebrating 40th Anniversary of Troponin Discovery, the 33rd NIPS Conference. Okazaki, JAPAN, October 25-28, 2005.
 
9.Liou, YM and JCH Chang. 2004 Differential effect of pH on calcium-induced conformational changes of cardiac troponin C in complex 48th American Biophysical Annual Meeting at Baltimore,MA, USA. , Feb 23-27, 2004. .
 
10.Liou, YM and MW Chen 2003 Calcium-Dependent Protein-Protein Interactions Induce Changes in Proximity Relationships of Cys-48 a 4th Eastern Asian Biophysical Symposium,Taipei, Taiwan, Nov. 3-7, 2003.
 
11.YP Wen*, JC Cheng, and YM Liou# 2002 Sex effect on troponin I degradation in avian blood serum,Annual Conferences of Biomedical Science..
 
12.YC Tseng*, JC Cheng, Y M Liou# 2002 Pyrene exercimer fluorescence assessing proximity changes of Cys-35 and Cys-84 in cardiac troponin C Annual Conferences of Biomedical Scienc.
 
13.Liou, Y.M, YC Tseng, JC Cheng 2002 Fluorescence spectroscopy discerning sarcomere length effect on conformational changes of Cys-35 and 46th American Biophysical Annual Meeting,at San Francisco, Ca, USA. , Feb 23-27. .
 
14.Cheng, J.C., et al. 2001 Effects of genetic background on myosin isozyme expression and ATPase activity of skeletal muscle in Annual Conferrence of Biomedical Scienc.
 
15.Goh, K.-S., et al 2001 Age-dependent polymorphic expression of troponin T in the pectoralis major muscle of domestic chicke Annual Conferrence of Biomedical Scienc.
 
16.Liou, YM, and MC Wu 2000 Effects of mechanical influence of varying sarcomere length on sulfhydryl reactivity of cardiac trop Biophys. J. 76: A257.
 
17.Goh, K.-S., et al. 2000 Polymorphic expression of myofilament protein troponin I in the pectoralis major muscle of domestic Annual conferrence of Chinese Animal Scienc.