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Hung, Hui-Chih - Professor
Hung, Hui-Chih Professor 繁體中文 English
Full-time teacher
Biotechnology
04-22840416#615、616
hchung@dragon.nchu.edu.tw
https://orcid.org/0000-0003-0180-1822

Molecular Enzymology; Protein Sciences

Education

Graduate from Major in Degree Period
National Defense Medical Center Graduate Institute of Life Sciences Ph. D. 08/1995~07/1999
National Defense Medical Center Institute of Biochemistry Master 08/1993~07/1995
Taipei Medical University School of Nutrition and Health Sciences Bachelor 09/1989~06/1993

Experience / Honor

Experience

Organization Department Title Period
National Chung Hsing University Department of Life Sciences Distinguished Professor 08/2011~present
National Chung Hsing University Department of Life Sciences Professor 08/2009~present
The Taiwan Society for Biochemistry and Molecular Biology The 25th & 26th member of council 04/2015~present
Academia Sinica Institute of Biological Chemistry Visiting Scholar 07/2019~08/2019
University of Washington USA Mitochondria & Metabolism Center Visiting Scholar 09/2018~01/2019
National Chung Hsing University Office of Research and Development Dean 02/2016~07/2018
National Chung Hsing University Office of Research and Development Deputy Dean 09/2012-01/2016
The Taiwan Society for Biochemistry and Molecular Biology The 24th General Secretary 06/2012-04/2015
National Chung Hsing University Institute of Genomics and Bioinformatics Director 09/2008~07/2014
National Chung Hsing University Department of Life Sciences Associate Professor 02/2006-07/2009
National Chung Hsing University Department of Life Sciences Assistant Professor 08/2002-01/2006
National Chung Hsing University Department of Zoology Assistant Professor 02/2002~07/2002
National Defense Medical Center Department of Biochemistry Postdoctoral Fellow 08/1999~01/2002

Honor

Year

Title

2011

Research Award for Junior Research Investigators, Academia Sinica　

2011~present

National Chung Hsing University Distinguished Professor

2009

Excellent Research Award (Top 10), National Chung Hsing University　

2007

Outstanding Young Scientist Award, National Chung Hsing University　

2006

Excellent Research Award (Top 10), National Chung Hsing University (NCHU)

2001

Postdoctoral Researcher Award, National Health Research Institutes

Research

Topic 1: Human Mitochondrial NAD(P)+-Dependent Malic Enzyme: A drug target in metabolism and anti-oxidation of cancer cells
m-NAD(P)-ME is essentially expressed in tumor mitochondria. Current proteomic studies indicated that m-NAD(P)-ME is overexpressed in many types of cancer cell lines. Although m-NAD(P)-ME may preferentially use NAD+ under physiological conditions, the enzyme can generate NADH and NADPH in the mitochondria and, therefore, may play dual roles in energy production and reductive biosynthesis. In tumor cells, glutamine and glutamate, not glucose, are the major energy sources, and m-NAD(P)-ME may play an important role in glutaminolysis, the metabolism of glutamine, for energy production in rapidly proliferating cells. In our lab, we study the enzymatic mechanism and regulation of human m-NAD(P)-ME, and target the human m-NAD(P)-ME for the development of cancer therapy in combination of current chemotherapeutic agents.

Topic 2: Protein-protein Interaction between Human Antizyme and Antizyme-interacting Proteins: Determinants of protein degradation in a ubiquitin-independent pathway
Antizyme (AZ) is the key regulator of ODC degradation, degraded through a ubiquitin-dependent 26S proteosomal degradation. AZ is originally identified as a negative modulator of ODC due to its role in facilitating the degradation of ODC. The binding of AZ promotes the dissociation of ODC homodimers and targets ODC for degradation by the 26S proteasome. ODC is a rate-limiting enzyme of cellular polyamine biosynthesis pathway, which is required for cell growth and proliferation. Therefore, AZ has been regarded as a tumor suppressor that negatively regulates cancer cell proliferation and transformation by inhibiting ODC activity and polyamine transport. In addition to ODC, AZ has been shown to bind to and facilitate the ubiquitin-independent degradation of cell cycle-regulating proteins, e.g. cyclin D1, Aurora-A kinase and Smad1 and a protein that regulates centrosome duplication, Mps1. In our lab, we study the molecular mechanism of AZ and its binding proteins ODC, AZI, and cyclin D1 in terms of quaternary structure and function including binding and degradation.

Topic 3: Peptidylarginine Deiminase 4-Catalyzed Citrullination and the Functional Influences: From catalytic mechanism to substrate identification
Protein citrullination is a posttranslational modification that converts a positively charged arginine to a neutral citrulline. This process is catalyzed by peptidylarginine deiminase (PAD, EC 3.5.3.15), which is a calcium-dependent enzyme that catalyzes the conversion of arginyl to citrullyl residues, accompanied by ammonia production. On target proteins, the conversion of positively charged arginine to neutral citrulline may cause a structural or conformational change. PAD type IV (PAD4) is the only isoform that can be localized in the nucleus and have been shown to be associated with rheumatoid arthritis and cancers. In our lab, we study the enzymatic mechanism of PAD4 in terms of the catalytic ability, the substrate-binding preference, and the quaternary structure. Moreover, we have been identified several novel substrates of PAD4, showing its involvement of various biochemical pathways. We are elucidating the functional consequences of these substrates to have a better understanding of the role of PAD4 during disease progression.

Journal Article

 
Yang YF, Wang CM, Hsiao IH, Liu YL, Lin WH, Lin CL, Hung HC*, Liu GY. 2022/03 Peptidylarginine deiminase 2 promotes T helper 17-like T cell activation and activated T cell-autonomous death (ACAD) through an endoplasmic reticulum stress and autophagy coupling mechanism, Cell Mol Biol Lett. 27(1):19. doi: 10.1186/s11658-022-00312-0. (Corresponding author). (SCI)
Liu YL, Hsiao IH, Lin YH, Lin CL, Jan MS, Hung HC*, Liu GY. 2022/01 Ornithine decarboxylase functions in both autophagy and apoptosis in response to ultraviolet B radiation injury, J Cell Physiol. 2022 Jan 12. doi: 10.1002/jcp.30678. Online ahead of print. (Corresponding author).
Yang YF, Lee CY, Hsieh JY, Liu YL, Lin CL, Liu GY, Hung HC*. 2021/08 Regulation of Polyamine Homeostasis through an Antizyme Citrullination Pathway,J Cell Physiol. 2021;1-18 doi: 10.1002/jcp.30252. (Corresponding author). (SCI)
Chang CC, Tsou SH, Chen WJ, Ho YJ, Hung HC*, Liu GY, Singh SK, Li HH, Lin CL. 2021/08 miR-302 Attenuates Mutant Huntingtin-Induced Cytotoxicity through Restoration of Autophagy and Insulin Sensitivity,Int. J. Mol. Sci. 22 (16):8424. doi: 10.3390/ijms22168424.. (SCI)
Hsieh JY, Yang HP, Tewary SK, Cheng HC, Liu YL, Tai SC, Chen WL, Hsu CH, Huang TJ, Chou CJ, Huang YN, Peng CT, Ho MC, Liu GY, Hung HC*. 2021/01 Single nucleotide variants lead to dysregulation of the human mitochondrial NAD(P)+-dependent malic enzyme,iSCIENCE. 24(2):102034. doi: 10.1016/j.isci.2021.102034. (Corresponding author). (SCI)
Liu YC, Liu YL, Hsieh JY, Wang CH, Lin CL, Liu GY, Hung HC*. 2020/12 Baicalein, 7,8-Dihydroxyflavone and Myricetin as Potent Inhibitors of Human Ornithine Decarboxylase, Nutrients 12(12):E3867. doi: 10.3390/nu12123867. (Corresponding author). (SCI)
Chang CC, Li HH, Tsou SH, Hung HC*, Liu GY, Korolenko TA, Lai TJ, Ho YJ, Lin CL. 2020/05 The Pluripotency Factor Nanog Protects against Neuronal Amyloid β-Induced Toxicity and Oxidative Stress through Insulin Sensitivity Restoration, Cells 9(6):1339. doi: 10.3390/cells9061339. (SCI)
Hsieh JY, Liu YC, Cheng IT, Lee CJ, Wang YH, Fang YS, Liu YL, Liu GY, Hung HC*. 2019/12 Critical Factors in Human Antizymes that Determine the Differential Binding, Inhibition, and Degradation of Human Ornithine Decarboxylase, Biomolecules 9(12). pii: E864. (corresponding author). (SCI)
Cheng YW, Chang CC, Chang TS, Li HH, Hung HC*, Liu GY, Lin CL. 2019/06 Aβ stimulates microglial activation through antizyme-dependent downregulation of ornithine decarboxylase, J Cell Physiol. 234(6):9733-9745. (SCI)
Hsieh JY, Shih WT, Kuo YH, Liu GY, Hung HC*. 2019/06 Functional Roles of Metabolic Intermediates in Regulating the Human Mitochondrial NAD(P)+-Dependent Malic Enzyme,Sci Rep. 9(1):9081. doi: 10.1038/s41598-019-45282-0. (corresponding author). (SCI)
Liu YL, Lee CY, Huang YN, Chen HY, Liu GY, Hung HC*. 2017/05 Probing the Roles of Calcium-Binding Sites during the Folding of Human Peptidylarginine Deiminase 4, Sci. Rep. 7(1):2429. (corresponding author). (SCI)
Lee CY, Lin CC, Liu YL, Liu GY, Liu JH, Hung HC*. 2017/02 Molecular Interplay between the Dimer Interface and the Substrate-Binding Site of Human Peptidylarginine Deiminase 4, Sci. Rep. 7:42662. (corresponding author). (SCI)
Chang HH, Liu GY, Dwivedi N, Sun B, Okamoto Y, Kinslow JD, Deane KD, Demoruelle MK, Norris JM, Thompson PR, Sparks JA, Rao DA, Karlson EW, Hung HC*, Holers VM, Ho IC. 2016/10 A molecular signature of preclinical rheumatoid arthritis triggered by dysregulated PTPN22, JCI Insight. 1(17):e90045. (SCI)
Liu YC, Lee CY, Lin CL, Chen HY, Liu GY, Hung HC*. 2015/09 Multifaceted interactions and regulation between antizyme and its interacting proteins cyclin D1, ornithine decarboxylase and antizyme inhibitor, Oncotarget 6(27):23917-23929. (corresponding author). (SCI)
Wu HY, Chen SF, Hsieh JY, Chou F, Wang YH, Lin WT, Lee PY, Yu YJ, Lin LY, Lin TS, Lin CL, Liu GY, Tzeng SR, Hung HC*, Chan NL. 2015/09 Structural basis of antizyme-mediated regulation of polyamine homeostasis, Proc. Natl. Acad. Sci. USA 112(36):11229-34. (corresponding author). (SCI)
Tung WF, Chen WJ, Hung HC*, Liu GY, Tung JN, Huang CC, Lin CL. 2015/08 4-Phenylbutyric Acid (4-PBA) and Lithium Cooperatively Attenuate Cell Death during Oxygen-Glucose Deprivation (OGD) and Reoxygenation, Cell Mol. Neurobiol. 35(6):849-859. (SCI)
Hsieh JY, Li SY, Tsai WC, Liu JH, Lin CL, Liu GY, Hung HC*. 2015/08 A small-molecule inhibitor suppresses the tumor-associated mitochondrial NAD(P)+-dependent malic enzyme (ME2) and induces cellular senescence, Oncotarget 6(24):20084-98. (corresponding author). (SCI)
Liao YF, Tzeng YM, Hung HC*, Liu GY. 2015/06 Dibenzoylmethane, hydroxydibenzoylmethane and hydroxymethyldibenzoylmethane inhibit phorbol-12-myristate 13-acetate induced breast carcinoma cell invasion, Mol. Med. Rep. 11(6):4597-4604. (SCI)
Li HH, Lu FJ, Hung HC*, Liu GY, Lai TJ, Lin CL. 2015/05 Humic Acid Increases Amyloid β-Induced Cytotoxicity by Induction of ER Stress in Human SK-N-MC Neuronal Cells, Int J. Mol. Sci. 16(5):10426-10442. (SCI)
Chang YL, Gao HW, Chiang CP, Wang WM, Huang SM, Ku CF, Liu GY, Hung HC*. 2015/03 Human Mitochondrial NAD(P)+-Dependent Malic Enzyme Participates in Cutaneous Melanoma Progression and Invasion, J. Invest. Dermatol. 135: 807-815. (corresponding author). (SCI)
Liao CL, Chen CM, Chang YZ, Liu GY, Hung HC*, Hsieh TY, Lin CL. 2014/10 Pine (Pinus morrisonicola Hayata) Needle Extracts Sensitize GBM8901 Human Glioblastoma Cells to Temozolomide by Downregulating Autophagy and O6-Methylguanine-DNA Methyltransferase Expression, J Agric Food Chem 62: 10458-10467. (SCI)
Hsieh JY, Li SY, Chen MC, Yang PC, Chen HY, Chan NL, Liu JH, Hung HC*. 2014/10 Structural characteristics of the nonallosteric human cytosolic malic enzyme, Biochim. Biophys. Acta. 1844: 1773-1783. (corresponding author). (SCI)
Lee CY, Liu YL, Lin CL, Liu GY, Hung HC* 2014/08 Functional roles of the dimer-interface residues in human ornithine decarboxylase, PLoS One 9(8): e104865. (corresponding author). (SCI)
Hsieh JY, Liu JH, Yang PC, Lin CL, Liu GY, Hung HC*. 2014/06 Fumarate Analogs Act as Allosteric Inhibitors of the Human Mitochondrial NAD(P)+-Dependent Malic Enzyme, PLoS One 9(6): e98385. (corresponding author). (SCI)
Hsu PC, Liao YF, Lin CL, Lin WH, Liu GY, Hung HC*. 2014/03 Vimentin Is Involved in Peptidylarginine Deiminase 2-Induced Apoptosis of Activated Jurkat Cells, Mol. Cells 37: 426-434. (corresponding author). (SCI)
Liu YL, Tsai IC, Chang CW, Liao YF, Liu GY, Hung HC*. 2013/01 Functional roles of the non-catalytic calcium-binding sites in the N-terminal domain of human peptidylarginine deiminase 4, PLoS One 8(1): e51660. (corresponding author). (SCI)
Murugan S, Hung HC*. 2012/12 Biophysical characterization of the dimer and tetramer interface interactions of the human cytosolic malic enzyme, PLoS One 7(12): e50143. (corresponding author). (SCI)
Liu YC, Hsu DH, Huang CL, Liu YL, Liu GY, Hung HC*. 2011/11 Determinants of the differential antizyme-binding affinity of ornithine decarboxylase, PLoS One 6(11): e26835. (corresponding author). (SCI)
Hsieh JY, Chen MC, Hung HC*. 2011/09 Determinants of nucleotide-binding selectivity of malic enzyme, PLoS One 6(9):e25312. (corresponding author). (SCI)
Hsieh JY, Yang JY, Lin CL, Liu GY, Hung HC*. 2011/09 Minimal antizyme Peptide fully functioning in the binding and inhibition of ornithine decarboxylase and antizyme inhibitor, PLoS one 6(9): e24366. (corresponding author). (SCI)
Wu CL, Liao YF, Hung YC, Lu KH, Hung HC*, Liu GY. 2011/09 Ornithine decarboxylase prevents dibenzoylmethane-induced apoptosis through repressing reactive oxygen species generation, J. Biochem. Mol. Toxicol. 25(5): 312-9. (SCI=2.042; Ranking: 57/92=62.0%, TOXICOLOGY, 2016). (SCI)
Liu YL, Chiang YH, Liu GY, Hung HC*. 2011/06 Functional role of dimerization of human peptidylarginine deiminase 4 (PAD4), PLoS one 6(6): e21314. (corresponding author). (SCI)
Liu YC, Liu YL, Su JY, Liu GY, Hung HC*. 2011/04 Critical Factors Governing the Difference in Antizyme-Binding Affinities between Human Ornithine Decarboxylase and Antizyme Inhibitor, PLoS one 6(4): e19253. (corresponding author). (SCI)
Wang MF, Liao YF, Hung YC, Lin CL, Hour TC, Lue KH, Hung HC*, Liu GY. 2011/04 Hydroxydibenzoylmethane induces apoptosis through repressing ornithine decarboxylase in human promyelocytic leukemia HL-60 cells, Exp. Mol. Med. 43(4): 189-96. (SCI)
Hsieh WC, Hsu PC, Liao YF, Young ST, Wang ZW, Lin CL, Tsay GJ, Lee H, Hung HC*, Liu GY. 2010/10 Overexpression of ornithine decarboxylase suppresses thapsigargin-induced apoptosis, Mol. Cells 30(4): 311-318. (corresponding author). (SCI)
Chang HP, Liang WC, Lyu RC, Chi MC, Wang TF, Su KL, Hung HC*, Lin LL. 2010/07 Effects of C‐terminal truncation on autocatalytic processing of Bacillus licheniformis gamma‐glutamyl transpeptidase, Biochemistry (Mosc) 75: 919‐929. (SCI)
Su KL, Liao YF, Hung HC*, Liu GY. 2009/09 Critical factors determining dimerization of human antizyme inhibitor, J. Biol. Chem. 284(39): 26768-26777. (corresponding author). (SCI)
Su KL, Chang KY, Hung HC*. 2009/08 Effects of structural analogues of the substrate and allosteric regulator of the human mitochondrial NAD(P)+-dependent malic enzyme, Bioorg. Med. Chem. 17(15): 5414-5419. (corresponding author). (SCI)
Hsieh JY, Su KL, Ho PT, Hung HC*. 2009/07 Long-range interaction between the enzyme active site and a distant allosteric site in the human mitochondrial NAD(P)+-dependent malic enzyme, Arch. Biochem. Biophys. 487(1): 19-27. (corresponding author). (SCI)
Hsieh JY, Chen SH, Hung HC*. 2009/07 Functional roles of the tetramer organization of malic enzyme, J. Biol. Chem. 284(27), 18096-18105. (IF=4.125; Ranking: 74/290=25.5%, BIOCHEMISTRY & MOLECULAR BIOLOGY, 2016) (corresponding author). (SCI)
Hsieh JY, Liu JH, Fang YW, Hung HC*. 2009/05 Dual roles of Lys57 at the dimer interface of human mitochondrial NAD(P)+-dependent malic enzyme, Biochem. J. 420(2): 201-209. (corresponding author). (SCI)
Hsieh JY, Chiang YH, Chang KY, Hung HC*. 2009/02 Functional role of fumarate site Glu59 involved in allosteric regulation and subunit-subunit interaction of human mitochondrial NAD(P)+-dependent malic enzyme, FEBS J. 276(4): 983-994. (corresponding author). (SCI)
Hsieh JY, Hung HC*. 2009/02 Engineering of the cofactor specificities and isoform-specific inhibition of malic enzyme, J. Biol. Chem. 284(7): 4536-4544. (corresponding author). (SCI)
Hsieh JY, Liu GY, Hung HC*. 2008/11 Influential factor contributing to the isoform-specific inhibition by ATP of human mitochondrial NAD(P)+-dependent malic enzyme: functional roles of the nucleotide binding site Lys346, FEBS J. 275(21): 5383-5392. (corresponding author). (SCI)
Hsu PC, Hung HC*, Liao YF, Liu CC, Tsay GJ, Liu GY. 2008/10 Ornithine Decarboxylase Attenuates Leukemic Chemotherapy Drugs-Induced Cell Apoptosis and Arrest in Human Promyelocytic HL-60 Cells, Leukemia Research 32(10), 1530-1540. (SCI)
Liao YF, Hung HC*, Hsu PC, Kao MC, Hour TC, Tsay GJ, Liu GY. 2008/07 Ornithine decarboxylase interferes within macrophage-like differentiation and matrix metalloproteinase-9 activation signaling by tumor necrosis factor alpha via NF-kB, Leukemia Research 32(7): 1124-1140. (SCI)
Liao YF, Hung HC*, Hour TC, Hsu PC, Kao MC, Tsay GJ, Liu GY. 2008/02 Curcumin induces apoptosis through ornithine decarboxylase-dependent pathway in human promyelocytic leukemia HL-60 cells, Life Sciences 82(7-8): 367-375. (SCI)
Su KL, Wen TH, Chou CY, Chang GG, Liu GY, Hung HC*. 2007/07 Structural variation manipulates the differential oxidative susceptibility and conformational stability of apolipoprotein E isoforms, Proteins: Struc. Funct. Bioinform. 68(1), 363-374. (corresponding author). (SCI)
Hung HC*, Lin CY, Liao YF, Hsu PC, Tsay GJ, Liu GY. 2007/05 The functional haplotype of peptidylarginine deiminase IV (S55G, A82V and A112G) associated with susceptibility to rheumatoid arthritis dominates apoptosis of acute T leukemia Jurkat cells, Apoptosis 12(3), 475-487. (first author). (SCI)
Liu GY, Liao YF, Hsu PC, Chang WH, Hsieh MC, Lin CY, Hour TC, Kao MC, Tsay GJ, Hung HC*. 2006/10 Antizyme, a natural ornithine decarboxylase inhibitor, induces apoptosis of haematopoietic cells through mitochondrial membrane depolarization and caspases’ cascade, Apoptosis 11(10), 1773-1788. (corresponding author). (SCI)
Hsieh JY, Liu GY, Chang GG, Hung HC*. 2006/08 Determinants of the dual cofactor specificities and substrate cooperativity of human mitochondrial NAD(P)+-dependent malic enzyme: the functional roles of Glutamine 362, J. Biol. Chem. 281(32), 23237-23245. (corresponding author). (SCI)
Hsu PC, Hour CT, Liao YF, Hung YC, Liu CC, Chang WH, Kao MC, Tsay GJ, Hung HC*, Liu GY. 2006/05 Increasing Ornithine Decarboxylase Activity Is Another Way of Prolactin Preventing Methotrexate-Induced Apoptosis: CROSSTALK BETWEEN ODC AND BCL-2, Apoptosis 11(3), 389-399. (SCI)
Liu GY, Liao YF, Chang WH, Liu CC, Hsieh MC, Hsu PC, Tsay GJ, Hung HC*. 2006/02 Overexpression of peptidylarginine deiminase IV features in apoptosis of haematopoietic cells, Apoptosis 11(2), 183-196. (corresponding author). (SCI)
Liao YF, Hsieh HC, Liu GY, Hung HC*. 2005/12 A Continuous Spectrophotometric Assay Method for Peptidylarginine Deiminase Type 4 Activity, Anal. Biochem. 347(20):176-181. (SCI)
Hung HC*, Kuo MW, Chang GG, Liu GY. 2005/11 Characterization of the functional role of allosteric site Asp102 in the regulatory mechanism of human mitochondrial NAD(P)+-dependent malic enzyme, Biochem. J. 392(Pt 1): 39-45. (SCI)
Hung HC*, Chien YC, Hsieh JY, Chang GG, Liu GY. 2005/09 The Functional Roles of ATP Binding Residues in the Catalytic Site of Human Mitochondrial NAD(P)+-Dependent Malic Enzyme, Biochemistry 44(38): 12737-12745. (SCI)
Huang CC, Hsu PC, Hung YC, Liao YF, Liu CC, Hour TC, Kao MC, Tsay GJ, Hung HC*, Liu GY. 2005/08 Ornithine decarboxylase prevents methotrexate-induced apoptosis by reducing intracellular reactive oxygen species production, Apoptosis 10(4): 895-907. (SCI)
Liao YF, Chang WH, Tsay GJ, Hour TC, Hung HC*, Liu GY. 2005/06 The PKC delta inhibitor, rottlerin, induces apoptosis of haematopoietic cell lines through mitochondrial membrane depolarization and caspases’ cascade, Life Sci. 77(6): 707-719. (SCI)
Liu GY, Hung YC, Hsu PC, Liao YF, Chang WH, Tsay GJ, Hung HC*. 2005/05 Ornithine decarboxylase prevents tumor necrosis factor alpha-induced apoptosis by decreasing intracellular reactive oxygen species, Apoptosis 10(3): 569-581. (SCI)
Hsu WC, Hung HC*, Tong L, Chang GG. 2004/06 Dual Functional Roles of ATP in Human Mitochondrial Malic Enzyme, Biochemistry 43(23): 7382-7390. (SCI)
Kuo CW, Hung HC*, Tong L, Chang GG. 2004/02 Metal-Induced Reversible Structural Interconversion of Human Mitochondrial NAD(P) -Dependent Malic Enzyme, Proteins: Struc. Funct. Bioinform. 54(3): 404-411. (SCI)
Hung HC*, Chen YH, Liu GY, Lee HJ, Chang GG. 2003/07 Equilibrium Protein Folding-Unfolding Process Involving Multiple Intermediates, B. Math. Biol. 65(4): 553-570. (SCI)
Yang Z, Zhang H, Hung HC*, Kuo CC, Tsai LC, Yuan HS, Chou WY, Chang GG, Tong L. 2002/02 Structural studies of the pigeon cytosolic NADP+-dependent malic enzyme, Protein Sci. 11(2): 332-341. (SCI)
Hung HC*, Chang GG. 2001/12 Multiple unfolding inetrmediates of human placental alkaline phosphatase in the equilibrium urea denaturation, Biophys. J. 81(6): 3456-3471. (SCI)
Hung HC*, Chang GG. 2001/01 Differentiation of the slow binding mechanism for magnesium ion activation and zinc ion inhibition of human placental alkaline phosphatase, Protein Sci. 10(1): 34-45. (SCI)
Chou WY, Kuo CC, Hung HC*, Huang TM, Chang GG. 2001 Metal binding site of pigeon liver malic enzyme, J. Med. Sci. 21, 201-206. (SCI)
Hung HC*, Chang GG, Yang Z, Tong L. 2000/11 Slow binding mechanism of malic enzyme: A general case, Biochemistry 39(46), 14095-14102. (SCI)
Yang Z, Batra R, Floyd DL, Hung HC*, Chang GG, Tong L. 2000/08 Potent and competitive inhibition of malic enzyme by lanthanide ions, Biochem. Biophys. Res. Commun. 274(2), 440-444. (SCI)
Chang GG, Huang TM, Hung HC*. 2000/07 Reverse micelles as the life process mimicking systems, Proc. Natl. Sci. Counc. Repub. China B 24(3), 89-100. (SCI)
Hung HC*, Huang TM, Chang GG. 1999 Partitioning of 4-nitrophenol in Aerosol-OT Reverse micelles, J. Chem. Soc. Perkin Trans. 2, 2177-2182. (SCI)
Hung HC*, Chang GG. 1998/10 Biphasic denaturation of human placental alkaline phosphatase in guanidinium chloride, Proteins: Struc. Funct. Genet. 33(1), 49-61. (SCI)
Hung HC*, Huang TM, Chang GG. 1998/02 Inhibitory effects of magnesium ion on the human placental alkaline phosphatase-catalyzed reaction in a reverse micellar system, J. Protein Chem. 17(2), 99-106. (SCI)
Huang TM, Hung HC*, Chang GG. 1998/02 Solvent kinetic isotope effects on the placental alkaline phosphatase in reverse micelles, Biochem. J. 330 (Pt1), 267-275. (SCI)
Hung HC*, Huang TM, Chang GG. 1997 Reverse micelles as model system to study leaving group effects on alkaline phosphatase-catalysed hydrolysis, J. Chem. Soc. Perkin Trans. 2, 2757-2760. (SCI)

Symposium Presentation

 
Hung HC*. 2020/02 Targeting Pyruvate Metabolism in the Metabolic Reprogramming of Acute Myeloid Leukemia, The 27th Symposium on Recent Advances in Cellular and Molecular Biology. Pingtung, Taiwan. February 5-7, 2020. (Invited Speaker).
Huang YN, Liu GY, Hung HC*. 2019/11 Mitochondrial NAD(P)+-Dependent Malic Enzyme and Its Specific Inhibitor Rewire Cell Metabolism in Leukemia, 2019 Annual Meeting of the Taiwan Society of Biochemistry & Molecular Biology. Taipei, Taiwan. November 15-17, 2019. (Invited Speaker).
Huang YN, Liu GY, Hung HC*. 2019/11 Targeting Human Mitochondrial NAD(P)+-Dependent Malic Enzyme and the Metabolic Reprogramming in Acute Myeloid Leukemia, 2019 Annual Meeting of Taiwan Society for Mitochondrial Research and Medicine. Taipei, Taiwan. November 9, 2019. (Invited Speaker).
CY Lee, Liu GY, Hung HC*. 2019/09 PAD4 regulates p53 function through protein citrullination, The 57th Annual Meeting of the Biophysical Society of Japan. Miyazaki, Japan. September. 24-26, 2019. (Invited Speaker).
Yang YF, Hsieh JY, Liu GY, Hung HC*. 2018/03 Ubiquitination Sites Essential for Degradation of Human Antizyme Inhibitor, The 33rd Joint Annual Conference of Biomedical Science, Taipei, Taiwan. March 24-25, 2018.
Yang HP, Hsieh JY, Liu GY, Hung HC*. 2018/03 Investigation of ubiquitination sites on human antizyme 2, The 33rd Joint Annual Conference of Biomedical Science, Taipei, Taiwan. March 24-25, 2018.
Tai SC, Chen WL, Hsieh JY, Hung HC*, Liu JH, Liu GY. 2018/03 Structural Studies of the Allosteric-Site and SNP mutants of Human mitochondrial NAD(P)+-Dependent Malic Enzyme, The 33rd Joint Annual Conference of Biomedical Science, Taipei, Taiwan. March 24-25, 2018.
Huang YN, Wu KH, Hsieh JY, Peng CT, Liu GY, Hung HC*. 2018/03 Human Mitochondrial NAD(P)+-Dependent Malic Enzyme Induces Leukemogenesis via Metabolic Reprogramming, The 33rd Joint Annual Conference of Biomedical Science, Taipei, Taiwan. March 24-25, 2018.
Hsu HY, Hsieh JY, Liu GY, Hung HC*. 2018/03 Natural Compound for Malic Enzyme Inhibition in Lung Cancer Cell Lines, The 33rd Joint Annual Conference of Biomedical Science, Taipei, Taiwan. March 24-25, 2018.
Cheng HC, Hsieh JY, Liu GY, Hung HC*. 2018/03 Study of the Single-Nucleotide Polymorphisms of the Human Mitochondrial NAD(P)+-Dependent Malic Enzyme Enzyme Activity and Senescence of Lung Cancer Cells, The 33rd Joint Annual Conference of Biomedical Science, Taipei, Taiwan. March 24-25, 2018.
Lee CY, Liu GY, Hung HC*. 2017/07 A Novel Mechanism Regulating Polyamine Homeostasis through an Antizyme Citrullination Pathway, 2nd International conference on Tumor & Cancer Immunology and Immunotherapy, Chicago, USA. July 17-18, 2017.
Liu GY, Liu YL, Liu Stanley, Wen-Hao Lin WH, Hung HC*. 2016/07 T Helper Subset Cell Activation and ACAD Dedicated by Peptidylarginine Deiminase 2, 16th IUBMB Conference, Vancouver, Canada. July 17-21, 2016.
Lee CY, Lin CC, Liu YL, Liu GY, Liu JH, Hung HC*. 2016/07 Molecular Interplay between the Dimer Interface and Substrate-Binding Site of Human Peptidylarginine Deiminase 4, 16th IUBMB Conference, Vancouver, Canada. July 17-21, 2016.
Lee CY, Chang MJ, Lin WH, Liu GY, Hung HC* 2015/09 PAD4 regulates cellular polyamine production through citrullinating the negative regulator antizyme, 14th Human Proteome Organization World Congress (HUPO): Translating Proteomics and Allied -Omics to the clinic, Vancouver, Canada. Sep 27-30, 2015.
Liu GY, Lin YH, Hung HC*. 2015/07 Ornithine decarboxylase participates in autophagy by ultraviolet B-induced cell injury, 29th Annual Symposium of the Protein Society, Barcelona, Spain. July 22-25, 2015.
Liu GY, Lin WH, Hung HC*. 2015/07 Peptidylarginine Deiminase 2 Assigns Activated T Cell Autonomous Death, 29th Annual Symposium of the Protein Society, Barcelona, Spain. July 22-25, 2015.
Hsieh JY, Liu YL, Liu GY, Hung HC*. 2015/07 Functional elements of a human antizyme essential for binding and inhibiting human ornithine decarboxylase, 29th Annual Symposium of the Protein Society, Barcelona, Spain. July 22-25, 2015.
Hung HC*, Pan L. 2014 A tea polyphenol epigallocatechin gallate (EGCG) displays a superior effect on enzyme inhibition of human ornithine decarboxylase, 23rd Biennial Congress of the European Association for Cancer Research. Munich, Germany. July 5–8.
Liu YL, Huang YN, Chen HY, Liu GY, Hung HC*. 2013 Folding Pathway of Human Peptidylarginine Deiminase 4, 21st International Conference on Analytical Ultracentrifugation, Hydrodynamics, Thermodynamics and Complementary Methods. Atami, Japan. September 23-28.
Liu YC, Cheng IT, Liu YL, Liu GY, Hung HC*. 2013 Critical Factors Determining the Differential Ornithine Decarboxylase-Binding Affinities between Human Antizyme 1 and Antizyme 3, 21st International Conference on Analytical Ultracentrifugation, Hydrodynamics, Thermodynamics and Complementary Methods. Atami, Japan. September 23-28.
Lee CY, Liu YL, Liu GY, Hung HC*. 2013 Functional Residues Contributing to Dimerization and Catalysis of Human Ornithine Decarboxylase, 21st International Conference on Analytical Ultracentrifugation, Hydrodynamics, Thermodynamics and Complementary Methods. Atami, Japan. September 23-28.
Liu YC, Cheng IT, Liu YL, Liu GY, Hung HC*. 2013 Study on Structure and Function of Human Cyclin D1 and Antizyme, 28st Annual Meeting of Biomedical Society. Taipei, Taiwan. March 23-24.
Liu YL, Liu GY, Hung HC*. 2012 Roles of the N-terminal Site Calcium Ions in Enzyme Catalysis and Stability of Peptidylarginine Deiminase 4 (PAD4), 13th FAOBMB International Congress of Biochemistry and Molecular Biology. Bangkok, Thailand. November 25-29.
Lee AY, Hung HC*, Liu GY. 2012 Pinus morrisonicola Hayata Extract Induces Apoptosis Effect on Leukemia Jurkat T Cell, 2012 The Taiwan Society for Biochemistry and Molecular Biology winter camp. Nantou, Taiwan. December 6-8.
Murugan S, Hung HC*. 2012 Biophysical Characterization of Dimer and Tetramer Interface Interactions of the Human Cytosolic Malic Enzyme, 13th FAOBMB International Congress of Biochemistry and Molecular Biology. Bangkok, Thailand. November 25-29.
Hung HC* 2011 Determinants of the differential antizyme-binding affinity of ornithine decarboxylase and antizyme inhibitor, The 16th Biophysics Conference. National Dong Hwa University, Taiwan. May 18-21.
Hung HC*. 2009 Tetramer organization and enzyme regulation of malic enzyme, “2009 Taiwan Enzyme Mechanism Conference” Institute of Biological Chemistry. Academia Sinica, Taiwan. December 15.
Su KL, Hung HC*. 2009 Critical Factors Determining Dimer Formation of Human Antizyme Inhibitor., 23rd Annual Symposium of the Protein Society. Boston, USA. July 25-29.
Hung HC*, Hsieh JY, Liu GY. 2008 Contribution of Critical Residue to ATP Sensitivity and Substrate Cooperativity of Human Mitochondrial NAD(P)+-Dependent Malic Enzyme: Functional Roles of Lys 346, 33rd FEBS Congress & 11th IUBMB Conference, Biochemistry of Cell Regulation. Athens, Greece. June 28-July 3.
Liu GY, Liao YF, Hung HC*. 2008 Peptidylarginine deiminase II participate in the activated T cell apoptosis,3 3rd FEBS Congress and 11th IUBMB Conference, Biochemistry of Cell Regulation. Athens, Greece. June 28-July 3.
Hung HC*, Chang KY, Liu GY. 2007 The Functional Roles of Allosteric Site Glutamate 59 Involving the Human Malic Enzyme Regulation, 32th FEBS Congress. Vienna, Austria: F1-60, p279, July 7-12.
Liao YF, Hung HC*, Lin CY, Liu GY. 2007 Curcumin induces apoptosis through generation of reactive oxygen species: its suppression by expression of ornithine decarboxylase, 32th FEBS Congress. Vienna, Austria: C2-57, p163, July 7-12.
Lin CY, Liao YF, Hsu PC, Hung HC*, Liu GY 2007 Ornithine decarboxylase prevents cancer chemotherapeutic drugs-induced apoptosis in HL-60 cells, 32th FEBS Congress. Vienna, Austria: C2-64, p165, July 7-12.
Liu GY, Lin CY, Hung HC*. 2007 Establishment of the dual luciferase frameshift assay in the acute T leukemia Jurkat cells, 32th FEBS Congress. Vienna, Austria: F1-60, p295, July 7-12.
Su KL, Chou CY, Chang GG, Liu GY, Hung HC*. 2006 The differential oxidative stability and conformational stability in human apolipoprotein E3 and E4 Arginine 158, 21st Annual Meeting of Biomedical Society. Taipei, Taiwan. March 18-19.
Ho PT, Liu GY, Chang GG, Hung HC*. 2006 Characterization of the interactions between Asp102 and Arg98 in allosteric site involving the regulatory mechanism of human mitochondrial NAD(P)+-dependent malic enzyme, 21st Annual Meeting of Biomedical Society. Taipei, Taiwan. March 18-19.
Hsieh JY, Liu GY, Chang GG, Hung HC*. 2006 Involvement of glutamine 362 in the cofactor binding and substrate cooperativity of human mitochondrial NAD(P)+-dependent malic enzyme, 21st Annual Meeting of Biomedical Society. Taipei, Taiwan. March 18-19.
Hsieh HC, Liao YF, Liu GY, Chang GG, Hung HC*. 2006 Characterization of the enzymatic activity of peptidylarginine deiminase 4: the pathogenic roles of single nucleotide polymorphism, 21st Annual Meeting of Biomedical Society. Taipei, Taiwan. March 18-19.
Liu GY, Hung HC*. 2005 Overexpression of peptidylarginine deiminase IV enhances apoptosis of haematopoietic cells, 30th FEBS Congress & 9th IUBMB Conference. Budapest, Hungary: O1-145P, p41, July 2-7.
Hung HC*, Wen DS, Su KL, Chang GG, Chou CY, Shiao MS, Liu GY. 2005 Role of Salt-bridges in Mediating the Differential Degradation of Apolipoprotein E Isoforms, Symposium of the National Research Program for Genomic Medicine (VI). Taipei, Taiwan.
Hung HC*, Wen DS, Su KL, Chang GG, Chou CY, Shiao MS, Liu GY. 2005 Influence of salt bridges on the differential oxidative degradation and conformational stability of apolipoprotein E isoforms, Symposium of the National Research Program for Genomic Medicine (VII), . Taipei, Taiwan.
Hsu PC, Hung YC, Liao YF, Hung HC*, Tsay GJ, Liu GY. 2004 Increasing Expression and Activity of Ornithine Decarboxylase is a Way to Prevent Methotrexate-Induced Apoptosis by Prolactin in HL-60 Cells, 2004 Joint Meeting of The Chinese Society of Immunology, Taiwan & The Rheumatology Association. Taipei, Taiwan ROC: 40-41, December 11-12.
Liao YF, Liu CC, Hung HC*, Tsay GJ, Liu GY. 2004 Ornithine Decarboxylase (ODC) Inhibits 92-kDa Type IV Collagenase/Gelatinase (MMP-9) Activation in HL60 Cells during Differentiation Induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), 2004 Joint Meeting of The Chinese Society of Immunology, Taiwan & The Rheumatology Association. Taipei, Taiwan ROC: 99-100, December 11-12.
Hung YC, Hsu PC, Liao YF, Hung HC*, Tsay GJ, Liu GY. 2004 Ornithine Decarboxylase Prevents Methotrexate-Induced Apoptosis by Reducing Intracellular Reactive Oxygen Species, 2004 Joint Meeting of The Chinese Society of Immunology, Taiwan & The Rheumatology Association. Taipei, Taiwan ROC: 99-100, December 11-12.
Hung YC, Hsu PC, Liao YF, Hung HC*, Tsay GJ, Liu GY. 2004 Ornithine decarboxylase prevents tumor necrosis factor alpha-induced apoptosis by decreasing intracellular reactive oxygen species, 2004 Joint Meeting of The Chinese Society of Immunology, Taiwan & The Rheumatology Association. Taipei, Taiwan ROC: 25-26, December 11-12.
Liu CC, Liao YF, Hung HC*, Tsay GJ, Liu GY. 2004 Ornithine Decarboxylase Resists Cisplatin, Etoposide and Paclitaxel-Induced Apoptotic Insults in Human Leukemia HL-60 cells, 2004 Joint Meeting of The Chinese Society of Immunology, Taiwan & The Rheumatology Association. Taipei, Taiwan ROC: 100, December 11-12.
Hung HC*, Wen DS, Su KL, Chang GG, Liu GY. 2004 Oxidative susceptibility and resistance of apolipoprotein E: Alzheimer’s disease related studies,Symposium of the National Research Program for Genomic Medicine (V). Nankang, Taipei, Taiwan.
Hung YC, Liao YF, Hung HC*, Tsay GJ, Liu GY 2003/11 Ornithine decarboxylase prevents peroxynitrit (OONO.-)- and hydrogen peroxide (H2O2)-induced apoptosis through decrease mitochondrial membrane potiential (?ym) in human promyelocyic leukemia HL-60 cells, 2003 Joint Meeting of The Chinese Society of Immunology, Taiwan & The Rheumatology Association. ROC Taichung, Taiwan: 33, November 22-23.
Hsu PC, Hung YC, Liao YF, Hung HC*, Tsay GJ, Liu GY 2003 Effect of glutathion and peroxynitrite induced the activation of matrix metalloproteinase 2 and matrix metalloproteinase 9 in RAW264.7 cells, 2003 Joint Meeting of The Chinese Society of Immunology, Taiwan & The Rheumatology Association. ROC Taichung, Taiwan: 106, November 22-23.
Hung HC* 2003 Oxidative stress and resistance of apolipoprotein E: Alzheimer’s disease related studies, Symposium of the National Research Program for Genomic Medicine (IV). Taipei, Taiwan.
Hung HC*, Liu GY, Chang GG. 2001 Computer data fitting in the equilibrium protein folding process involving multiple intermediates, Computer Science and Biology GCB 2001. Braunschweig, Germany.
Hung HC*, Chang GG. 1998 Enzymatically fully active intermediate of human placental alkaline phosphatase during guanidinium chloride denaturation, 12th Symposium of the Protein Society. San Diago, CA, USA, pp.102.
Hung HC*, Chang GG. 1998 Multiphasic denaturation of human placental alkaline phosphatase, Symposium on Enzyme Structure and Function. Nantou, Taiwan.
Chang GG, Hung HC*. 1998 Conformational stability of human placental alkaline phosphatase, Symposium on Enzyme: Structure and Function. Nantou, Taiwan.
Hung HC*, Chang GG. 1997 Anomalous effects of guanidinium chloride on human placental alkaline phosphatase, The Third Symposium on Resent Advances in Biophysics P2. Nantou, Taiwan.

Research Project

年度
補助機關
計畫名稱
計畫起迄日期
2022
國家科學及技術委員會
人類 p53 蛋白之新穎後轉譯修飾研究：探討瓜胺酸化p53 蛋白之結構和功能，以及細胞應激所誘導之獨特瓜胺酸化模式
2022/08/012023/07/31
2022
教育部
111年度「精準健康產業跨領域人才培育計畫」夥伴學校
2022/02/012023/01/31
2022
其他公司
分析級超高速離心機
2022/01/012022/12/31
2021
教育部
110度「生醫產業與新農業跨領域人才培育計畫」之B類「生醫產業與新農業創新創業人才培育計畫」
2021/02/012022/01/31
2021
其他公司
分析級超高速離心機
2021/01/012021/12/31
2021
國家科學及技術委員會
探討蛋白質瓜胺酸化對TP53蛋白功能調節之影響
2021/08/012022/07/31
2020
科技部
探討人類粒線體NAD(P)+-依賴型蘋果酸?之單一核?酸變異性及乙醯化所引發之代謝重置
2020/08/012021/07/31
2020
教育部
109年度生醫產業與新農業跨領域人才培育計畫B類生醫產業與新農業創新創業人才培育計畫(內含彈性經費25,000元)
2020/02/012021/01/31
2020
其他公司
分析級超高速離心機(單位績效)
2020/01/012020/12/31
2019
科技部
製造無融合蛋白的纖維細胞生長因子於細胞治療之應用
2019/11/012020/10/31
2019
通用幹細胞股份有限公司
製造無融合蛋白的纖維細胞生長因子於細胞治療之應用
2019/11/012020/10/31
2019
科技部
抗酶蛋白的N-末端泛素化和瓜胺酸化之研究：抗酶蛋白後轉譯修飾之生物意義
2019/08/012020/07/31
2019
其他公司
分析級超高速離心機(單位績效)
2019/01/012019/12/31
2019
教育部
108年度「生醫產業與新農業跨領域人才培育計畫」之B類「生醫產業與新農業創新創業人才培育計畫」
2019/02/012020/01/31
2018
科技部
探討抗酶促進型以及NAD(P)H [苯]醌氧化酶1抑制型之泛素非依賴型蛋白質降解途徑
2018/08/012020/01/31
2018
其他公司
分析級超高速離心機(單位績效)
2018/01/012018/12/31
2018
教育部
107年度「生醫產業與新農業跨領域人才培育計畫」之B類「生醫產業與新農業創新創業人才培育計畫」
2018/03/142019/01/31
2017
其他公司
中部科學工業園區委辦評估投資案審查費(單位績效)
2017/01/012017/12/31
2017
教育部
生技產業創新創業人才培育計畫-醫藥生技產業教學實習推動中心
2017/01/012017/12/31
2017
科技部
探討抗酶促進型以及NAD(P)H [苯]醌氧化酶1抑制型之泛素非依賴型蛋白質降解途徑
2017/08/012018/07/31
2017
科技部
探討人類粒線體NAD(P)+-依賴型蘋果酸酶之後轉譯修飾以及單一核苷酸多型性對其結構與功能之影響
2017/08/012019/07/31
2016
科技部
探討人類粒線體NAD(P)+-依賴型蘋果酸酶之後轉譯修飾以及單一核苷酸多型性對其結構與功能之影響
2016/08/012017/07/31
2016
生工有限公司
製造具經濟價值之人類重組生物醫用蛋白及酵素並發展反應試劑套組(1/2)
2016/06/012017/05/31
2016
教育部
105年度教育部生技產業創新創業人才培育計畫-醫藥生技產業教育實習推動中心
2016/01/012016/12/31
2016
其他公司
中部科學工業園區委託評估投資案審查費(單位績效)
2016/01/012016/12/31
2016
科技部
探討抗酶促進型以及NAD(P)H [苯]醌氧化酶1抑制型之泛素非依賴型蛋白質降解途徑
2016/08/012017/07/31
2016
科技部
製造具經濟價值之人類重組生物醫用蛋白及酵素並發展反應試劑套組(1/2)
2016/06/012017/05/31
2015
教育部
104年度生技產業創新創業人才培育計畫-醫藥生技產業教育實習推動中心
2015/01/272015/12/31
2015
其他公司
分析級超高速離心機(單位績效)
2015/01/012015/12/31
2015
科技部
探討人類粒線體NAD(P)+-依賴型蘋果酸酶之後轉譯修飾以及單一核苷酸多型性對其結構與功能之影響
2015/08/012016/07/31
2014
科技部
人類胜肽精胺酸脫亞胺酶之目標受質蛋白與胜肽片段專一性，及其結合蛋白特性之鑑定(3/3)
2014/08/012015/07/31
2014
科技部
從蛋白質結構與功能角度探討人類蘋果酸之異構專一特性:異位調節、次單元-次單元交互作用、及異構專一性小分子藥物
2014/08/012015/07/31
2014
其他公司
分析級超高速離心機(單位績效)
2014/01/012014/12/31
2013
其他公司
分析級超高速離心機對外服務收入
2013/01/012013/12/31
2013
科技部
人類胜肽精胺酸脫亞胺酶之目標受質蛋白與胜肽片段專一性，及其結合蛋白特性之鑑定(2/3)
2013/08/012014/07/31
2013
科技部
從蛋白質結構與功能角度探討人類蘋果酸之異構專一特性:異位調節、次單元-次單元交互作用、及異構專一性小分子藥物
2013/08/012014/07/31
2012
科技部
人類胜肽精胺酸脫亞胺肽之目標受質蛋白與胜肽片段專一性，及其結合蛋白特性之鑑定(1/3)
2012/08/012013/07/31
2012
科技部
從蛋白質結構與功能角度探討人類蘋果酸之異構專一特性:異位調節、次單元-次單元交互作用、及異構專一性小分子藥物
2012/08/012013/07/31
2012
其他公司
分析級超高速離心機對外服務收入
2012/01/012012/12/31
2011
行政院國家科學委員會
探討人類細胞週期素D1 (cyclin D1)與抑?蛋白(antizyme)複合物結合位之特性及其應用
2011/08/012012/07/31
2011
瑞基海洋生物科技股份有限公司
製造抗氧化及耐熱之重組核酸抑制蛋白應用於核酸擴增試劑
2011/11/012012/10/31
2011
行政院國家科學委員會
製造抗氧化及耐熱之重組核酸抑制蛋白應用於核酸擴增試劑
2011/11/012012/10/31
2010
行政院國家科學委員會
人類蘋果酸不同異構型之酵素動力學研究及異位調節機制之探討
2010/08/012011/07/31
2009
行政院國家科學委員會
以生物物理學及結構生物學方法探討人類鳥胺酸脫羧，抗，與抗抑制劑 三者之間交互作用之機制及其生物意義
2009/08/012010/07/31
2008
行政院國家科學委員會
從蛋白質結構與功能角度探討蘋果酸之異位調節機制
2008/08/012009/07/31
2007
行政院國家科學委員會
從蛋白質結構與功能角度探討蘋果酸之異位調節機制
2007/08/012008/07/31
2006
行政院國家科學委員會
人類粒腺體NAD(P)+-依賴型蘋果酸j.之分子調控機制(3/3)
2006/08/012007/07/31
2006
教育部
尖端生物技術科技人才培育計畫-生物資訊與系統生物學教學資源中心
2006/04/182006/12/31
2005
行政院國家科學委員會
人類粒腺體NAD(P)+-依賴型蘋果酸之分子調控機制(2/3)
2005/08/012006/07/31
2005
行政院國家科學委員會
人類脂蛋白元E與β-類澱粉蛋白質凝集化及去凝集化之分析-阿滋海默症相關研究(3/3)
2005/05/012006/04/30
2004
行政院國家科學委員會
人類粒腺體NAD(P)+-依賴型蘋果酸ｊ.之分子調控機制(1/3)
2004/08/012005/07/31
2004
行政院國家科學委員會
人類脂蛋白元E與β－澱粉蛋白質凝集化及去凝集化之分析－阿滋海默症相關研究(2/3)
2004/05/012005/04/30
2003
行政院國家科學委員會
人類脂蛋白元E與β-類澱粉蛋白質凝集化及去凝集化之分析—阿茲海默症相關研究
2003/05/012004/04/30
2002
行政院國家科學委員會
人類粒腺體NAD(P)+-依賴型蘋果酸j.之異位調節機制
2002/08/012003/07/31
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