Immunology. Medical Microbiology. Microbial Pathogenesis. Zoonosis.
|
Graduate from |
Major in |
Degree |
Period |
|
University of California, Davis |
Microbiology |
Ph.D. |
2021 |
|
National Chung Hsing University |
Graduate Institute of Biotechnology |
M.S. |
2012 |
|
National Chung Hsing University |
Plant Pathology |
B.S. |
2010 |
Our research team investigates how bacterial pathogens manipulate the host innate immune system to promote their survival and pathogenesis. We focus on Listeria monocytogenes, a major foodborne pathogen that poses a severe health risk to vulnerable populations such as children, the elderly, and immunocompromised individuals. Infections in these groups often lead to life-threatening conditions. Moreover, Listeria infection during pregnancy is associated with adverse outcomes, including miscarriage, stillbirth, and neonatal infection.
Our studies aim to elucidate the molecular mechanisms underlying Listeria infection during pregnancy, with a particular emphasis on its interactions with host cells. By dissecting the strategies used by Listeria to deploy virulence factors, evade immune defenses, and disrupt placental function, we seek to advance our understanding of host-pathogen dynamics and placenta-associated pathologies.
The extensive global production of plastics has resulted in the pervasive presence of micro- and nanoplastic particles, now recognized as a significant source of environmental contamination. Emerging evidence indicates that these particles can accumulate in human tissues and exert cytotoxic effects, raising concerns about their impact on reproductive health.
Our research focuses on the role of plastic particle exposure in pregnancy complications, specifically investigating how these particles compromise placental function and contribute to adverse pregnancy outcomes. Using a multidisciplinary approach that integrates in vitro cell models, animal studies, and analysis of human placental tissues, we aim to unravel the molecular mechanisms by which plastic particles impair placental immune regulation and barrier integrity. Ultimately, this research seeks to enhance public awareness of the health risks posed by plastic pollution and inform strategies to mitigate plastic-related reproductive hazards.