國立中興大學生命科學系

Education

Graduated from	Major in	Degree	Period
National Yang-Ming University	Institute of Physiology, College of Medicine	Ph.D	2006/09-2013/04
National Chung-Hsing University	Department of Life Sciences, College of Life Sciences	B.S	2000/09-2004/06

Experience / Honor

Organization	Department	Title	Period
National Chung-Hsing University	Department of Life Sciences, College of Life Sciences	Assistant Professor	2024/08-present
National Health Research Institutes	Institute of Cellular and System Medicine	Post-doctoral Fellow	2017-2023
National Yang-Ming University	Institute of Brain Science	Post-doctoral Fellow	2014-2017
National Yang-Ming University	Brain Research Center	Post-doctoral Fellow	2013-2014

Honors, Awards and Prize

Elected paper in 2019 NHRI Research Day, Miaoli, Taiwan, 2019

Research Paper Publication Award of Post-doctoral Fellow, Ministry of Science and Technology, Taipei, Taiwan, 2015

Excellent Research Paper Publication Award and Scholarship, National Yang-Ming University, Taipei, Taiwan, 2015

Excellent Research Paper Publication Award and Scholarship, National Yang-Ming University, Taipei, Taiwan, 2013

Scholarship and Research Award of Best Ph.D Thesis, National Yang-Ming University, Taipei, Taiwan, 2013

Tadokoro 1st Prize for Best Oral Presentation, the 9th Asian & Oceanian Epilepsy Congress (AOEC 2012), 22nd-25th March 2012, Manila, Philippines, 2012

Research

Brain injuries trigger a cascade of neuroinflammatory responses, leading to further damage to brain tissue. The inflammatory responses in the brain are associated with neuronal death, changes in synaptic plasticity, and the chronic progression of various neurological diseases such as traumatic brain injury, stroke, and epilepsy. Interestingly, a significant increase in neurogenesis in the hippocampal dentate gyrus observed in animal models in response to varies initial precipitating injuries. This increase in neurogenesis has traditionally been thought to compensate for damaged neurons. However, the characteristics and electrophysiological properties of these newly generated neurons, as well as their location, differ from those produced under normal physiological conditions. This leads to structural and functional abnormalities in the hippocampal circuitry, which are closely associated with subsequent cognitive deficits and pathological consequences. Based on these observations, we focus on investigating the effects of neuroinflammatory responses on neurogenesis and their involvement in the mechanisms of neurological diseases. Our research topics include:

1. The relationship between hippocampal abnormal neurogenesis induced by brain injury and thalamic diaschisis (functional disconnection), as well as their impact on cognitive function.

2. The effect of soluble epoxide hydrolase activity on abnormal neurogenesis in the hippocampus following sensorimotor cortical damage.

3. The pathological mechanisms underlying ischemic stroke-related dysosmia.

Lab Member

PhD student::

李淳幼

Undergraduate trainee:

張廷軒楊鈺寬林利剛蔡子彬羅涵郁江琦

Journal Article

Yeh CF, Chuang TY, Lan MY, Lin YY, Huang WH and [*Hung YW]. 2024. Soluble epoxide hydrolase inhibitor ameliorates olfactory dysfunction, modulates microglia polarization, and attenuates neuroinflammation after ischemic brain injury. Journal of Neuroimmune Pharmacology (accepted)【SCI】I.F. 5.2, 40/354 (11.3%) PHARMACOLOGY & PHARMACY (*corresponding author)

Yeh CF, Lan MY, Lin CC, [Hung YW], Huang WH, Lai YL. 2024. Dual blockade of IL-4 and IL-13 with dupilumab ameliorates sensorineural olfactory dysfunction in mice with eosinophilic sinonasal inflammation. Rhinology (accepted)【SCI】I.F. 4.8, 3/65 (4.6%) OTORHINOLARYNGOLOGY

#Huang WH, [#Hung YW], #Hung W, Lan MY and *Yeh CF. 2024. Murine model of eosinophilic chronic rhinosinusitis with nasal polyposis inducing neuroinflammation and olfactory dysfunction. Journal of Allergy and Clinical Immunology (in press)【SCI】I.F. 14.2, 1/28 (1.8%) ALLERGY (#equal contribution)

[Hung YW], Lu GL, Chen HH, Tung HH and *Lee SL. 2023. Gliptins normalize posttraumatic hippocampal neurogenesis and restore cognitive function after controlled cortical impact on sensorimotor cortex. Biomedicine & Pharmacotherapy 165: 115270.【SCI】I.F. 7.5, 22/278 (7.91%) PHARMACOLOGY & PHARMACY

[Hung YW], Wang Y and *Lee SL. 2020. DPP-4 inhibitor reduces striatal microglial deramification after sensorimotor cortex injury induced by external force impact. FASEB Journal 34: 6950-6964.【SCI】I.F. 4.966, 9/93 (9.6%) BIOLOGY

Yeh CF, Chuang TY, [Hung YW], Lan MY, Tsai CH, Huang HX and *Lin YY. 2019. Soluble epoxide hydrolase inhibition enhances anti-inflammatory and antioxidative process, modulates microglia polarization and promotes recovery after ischemic stroke. Neuropsychiatric Disease and Treatment 15: 2927-2941【SCI】I.F. 2.228, 84/146 (57.53%) PSYCHIATRY

Yeh CF, Chuang TY, [Hung YW], Lan MY, Tsai CH, Huang HX and *Lin YY. 2019. Development of a Modified Surgical Technique for Simulating Ischemic Cerebral Cortex Injury in Rats. In Vivo 33: 1175-1181.【SCI】I.F. 1.609, 102/136 (75%) MEDICINE, RESEARCH & EXPERIMENTAL

Yeh CF, Chuang TY, [Hung YW], Lan MY, Tsai CH, Huang HX and *Lin YY. 2019. Inhibition of soluble epoxide hydrolase regulates monocyte/macrophage polarization and improves neurological outcome in a rat model of ischemic stroke. Neuroreport 30: 567-572.【SCI】I.F. 1.146, 247/267 (92.5%) NEUROSCIENCES

[Hung YW], Lin YH, Chan CY, Wang WS, Chiu CF, Chiu CC, Chiu HW, Tsai WH and *Hung SW. 2019. Pharmacokinetic study of amoxicillin in Japanese eel Anguilla japonica by high performance liquid chromatography with fluorescence detection. Aquaculture Reports 13: 100184.【SCI】I.F. 1.887, 20/52 (38.46%) FISHERIES

[Hung YW], Lin YH, Chen MH, Wang WS, Chiu CF, Chiu CC, Chiu HW, Tsai WH, and *Hung SW. 2018. Pharmacokinetic study of florfenicol in Bester sturgeon, a cultured hybrid of Huso huso×Acipenser ruthenus by high performance liquid chromatography equipped with UV detector. Aquaculture 495: 558-567.【SCI】I.F. 2.710, 17/106 (16.03%) MARINE & FRESHWATER BIOLOGY

[Hung YW] and *Lin YY. Targeting soluble epoxide hydrolase for temporal lobe epilepsy. 2016. Journal of Clinical & Experimental Neuroimmunology 1: 109.

[Hung YW], Hung SW, Wu YC, Wong Lin-Kin, Lai MT, Shih YH, *Lee TS, *Lin YY. 2015. Soluble epoxide hydrolase activity regulates inflammatory responses and seizure generation in two mouse models of temporal lobe epilepsy. Brain Behavior and Immunity 43: 118-129.【SCI】I.F. 5.889, 28/252 (11.11%) NEUROSCIENCES (This paper was awarded the Research Paper Publication Award of Post-doctoral Fellow)

[Hung YW], Lai MT, Tseng YJ, Chou CC, and *Lin YY. 2013. Monocyte chemoattractant protein-1 affects migration of hippocampal neural progenitors following status epilepticus in rats. Journal of Neuroinflammation 10: 11. 【SCI】I.F. 4.902, 48/252 (19.04%) NEUROSCIENCES

[Hung YW], Yang DI, Huang PY, Lee TS, Kuo TBJ, Yiu CH, Shih YH, and *Lin YY. 2012. The duration of sustained convulsive seizures determines the pattern of hippocampal neurogenesis and the development of spontaneous epilepsy in rats. Epilepsy Research 98: 206-215.【SCI】I.F. 2.290, 87/192 (45.31%) CLINICAL NEUROLOGY

Symposium Presentation

*Cheng CH, [Hung YW], Hung SW, Wang PN. 2024 Effects of multimodal intervention on plasma brain-derived neurotrophic factor (BDNF) and electrophysiological responses in older adults with subjective cognitive decline (SCD).The 64th Annual Meeting of Society for Psychophysiological Research, Prague, Czech Republic. (Poster)

[Hung YW], Lu GL, Chen HH *Lee SL. 2022 Dipeptidyl Peptidase-4 Inhibitors Attenuate Hippocampal Aberrant Neurogenesis and Cognitive Decline Following Sensorimotor Traumatic Brain Injury. 2022 NHRI Research Day, Miaoli, Taiwan. (Poster)

[Hung YW], and *Lee SL. 2021 Effect of Dipeptidyl Peptidase-4 Inhibitors on Hippocampal Aberrant Neurogenesis, Neuronal Ectopia and Cognitive Decline Following Sensorimotor Traumatic Brain Injury. 2021 NHRI Research Day, Miaoli, Taiwan. (Poster)

[Hung YW], Wang Y, *Lee SL. 2020 Selective Neuroprotective Effect of Dipeptidyl Peptidase-4 Inhibitors in Experimental Traumatic Brain Injury. 2020 NHRI Research Day, Miaoli, Taiwan. (Poster)

[Hung YW], Wang Y, *Lee SL. 2019 Divergent Effects of Gliptins on the Pathological Outcomes in a Mouse Model of Traumatic Brain Injury. The 49th Annual Meeting of the Society for Neuroscience, Chicago, IL, USA. (Poster)

[Hung YW], Wang Y, *Lee SL. 2019. Keystone Symposium on Molecular and Cellular Biology, Neurodegerertive Diseases: New Insights and Therapeutic Opportunities. (poster)

[Hung YW], Wang Y, *Lee SL. 2019 Favorable protective effect of sitagliptin against traumatic brain injury in mice. 2019 NHRI Research Day, Miaoli, Taiwan. (Oral, This paper was awarded for elected paper in 2019 NHRI Research Day)

[Hung YW], Tseng YJ, Wu YC, *Lin YY. 2016 Involvement of toll-like receptor 2 in inflammatory responses and seizure generation in two mouse models of temporal lobe epilepsy. The 46th Annual Meeting of the Society for Neuroscience, San Diego, CA, USA. (Poster)

[Hung YW], Chou CC, Lai MT, Tseng YJ, *Lin YY. 2012 Monocyte chemoattractant protein-1 affects ectopic migration of neural progenitors within the hippocampal dentate gyrus of rats with status epilepticus. The 9th Asian & Oceanian Epilepsy Congress, Manila, Philippines. (Oral, This paper was awarded the Tadokoro Prize, Best Platform Presentation, 1st Prize)

[Hung YW]: Invited Speaker for “Research Highlights of Young Investigators in the Asian & Oceanian Region” The 9th Asian & Oceanian Epilepsy Congress (AOEC 2012), Manila, Philippines.

*Lin YY, Lai MT, [Hung YW], Lee TS. 2010. Soluble epoxide hydrolase regulates hippocampal neuroinflammation in adult mice after pilocarpine-induced status epilepticus. The 64th Annual Meeting of the American Epilepsy Society. (Poster)

[Hung YW], Huang PY, Wang CH, *Lin YY. 2009. Duration of status epilepticus affects the neurogenesis in the dentate gyrus of adult rats. The 24th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan. (Poster)

Huang PY, [Hung YW], Chiou SH, Fu YS, *Lin YY. 2009. Roles of human umbilical mesenchymal cell transplantation in experimental temporal lobe epilepsy of rats. The 24th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan. (Poster)