劉英明 - 教授
劉英明 教授 繁體中文 English
專任教師
生理
04-22840416#717、718

肌肉蛋白,生物物理,細胞分子生理,分子馬達

實驗室介紹

學歷

畢業學校 主修學門系所 學位 時期
美國匹茲堡大學 生理學 博士 1987/09 - 1992/04
國立台灣大學 動物學系 學士 1980/10 - 1984/06

經歷 / 榮譽

服務機關 服務部門 職稱 時期
國立中興大學 生命科學系 教授 2005/08~迄今
國立中興大學 生命科學系 副教授 2002/08 - 2005/07
國立中興大學 動物學系 副教授 1994/08 - 2002/07
私立中山醫學大學 生理學系 副教授 1994/02 - 1994/07
美國哈佛大學 心血管研究部 博士後研究 1992/08 - 1994/01

研究方向

研究興趣
1 臍帶幹細胞生長與分化
2 細胞骨骼以及肌肉細胞之分子馬達
3 建立研究心血管功能的實驗動物模式
4 造骨蛋白之生物功能

研究主題
1 臍帶wharton's jelly 幹細胞生長與分化之分子調控
2 細胞骨骼以及肌肉分子馬達之細胞運動功能的研究
3 建立研究心血管功能的實驗動物模式
4 肌肉蛋白分子調控鈣離子活化肌肉收縮的分子機轉

目前研究計畫
1 利用心肌傷害之實驗動物鼠來研究綠茶多酚保護心肌受損的機制探討 (NSC 98-2320-B-005-001-MY2)

研究室人員

博士班
廖娟妙, 陳建佑

碩士班
彭康維,許源彰,邱冠穎,許建生

大學部

研究助理

博士後研究

畢業生

期刊論文

 
Kuo CH, Lee IC, Huang BJ, Chen CM, Liou YM (劉英明)*. Effects of Aldo-Keto Reductase Family 1 Member A on Osteoblast Differentiation Associated with Lactate Production in MC3T3-E1 Preosteoblastic Cells. Biochem Cell Biol. 2022 Oct 1;100(5):413-424. doi: 10.1139/bcb-2022-0108. Epub 2022 Jul 20. PMID: 35858481.
Lin YM, Situmorang JH, Guan JZ, Hsieh DJ, Yang JJ, Chen MY, Loh CH, Kuo CH, Lu SY, Liou YM (劉英明)*, Huang CY(黃志揚)*. ZAKβ Alleviates Oxidized Low-density Lipoprotein (ox-LDL)-Induced Apoptosis and B-type Natriuretic Peptide (BNP) Upregulation in Cardiomyoblast. Cell Biochem Biophys. 2022 Jul 1. doi: 10.1007/s12013-022-01080-6. Epub ahead of print. PMID: 35776316.
Inn-Chi Lee (李英齊)*, Jiann-Jou Yang, Ying-Ming Liou (劉英明), Wong SH. KCNQ2 Selectivity Filter Mutations Cause Kv7.2 M-Current Dysfunction and Configuration Changes Manifesting as Epileptic Encephalopathies and Autistic Spectrum Disorders. Cells. 2022 Mar 5;11(5):894.
Inn-Chi Lee (李英齊)*, Jiann-Jou Yang and Ying-Ming Liou (劉英明) (2021, Dec). Early Blood Glucose Level Post-Admission Correlates with the Outcomes and Oxidative Stress in Neonatal Hypoxic-Ischemic Encephalopathy. Antioxidants. Chung Shan Medical University and National Chung Hsing University grant: t NCHU-CSMU-11009.
郭家孝,陳建宇,陳全木,黃千威,劉英明*,Chia-Hsiao Kuo; Jiann-Yeu Chen; Chuan-Mu Chen; Cian Wei Huang,Ying-Ming Liou* (2021, Jan). Effects of varying gelatin coating concentrations on RANKL-induced osteoclastogenesis.. Experimental Cell Research, 400(2):112509. (SCI, 117/244,ONCOLOGY). MOST 106-2320-B-005-003-MY2. 本人為通訊作者.
Lee IC (李英齊)*, Yang JJ, Wong SH, Liou YM (劉英明), Li SY. (2020, Oct). Heteromeric Kv7.2 current changes caused by loss-of-function of KCNQ2 mutations are correlated with long-term neurodevelopmental outcomes. Sci Rep. , 10(1):13375.
陳建佑,張坤成,劉英明(通訊作者),Jan-Yow Chen, Kuan-Cheng Chang ,Ying-Ming Liou (Corresponding author) (2020, Jun). Matrix metalloproteinase 1 1 G/2 G gene polymorphism is associated with acquired atrioventricular block via linking a higher serum protein level. Scientific Reports, 10(1):9900.
Chen JY (陳建佑), Liou YM(劉英明), Chang KC. (2019, Jul). Gene Polymorphisms of Methylenetetrahydrofolate Reductase and Apolipoprotein E: Causes or Markers for Coronary Artery Disease?. Cardiology., 142(4):208-210.. (SCI, 103/136, CARDIAC & CARDIOVASCULAR SYSTEMS).
張主龍,陳建宇,施明智,王志略,劉英明*(中文),Chu-Lung Chan, JiannYeu Chen, Ming-Chih Shih, Chih-Lueh Albert Wang, Ying-Ming Liou* (2019, Jan). L-caldesmon alters cell spreading and adhesion force in RANKL-induced osteoclasts. Journal of Biomedical Science, 2019 Jan 24;26(1):12.. (SCI, 20/136,MEDICINE, RESEARCH &EXPERIMENTAL). MOST 106-2320-B005-003-MY2. 本人為通訊作者.
Liou YM, Chan CL, Huang R, Wang CA. (2018, Sep). Effect of L-Caldesmon on Osteoclastogenesis in RANKL-Induced RAW264.7 Cells.. JOURNAL OF CELLULAR PHYSIOLOGY, 2018 Sep;233(9):6888-6901. (SCI, 11/81,PHYSIOLOGY). MOST 105-2320-B-005-007. 本人為第一作者、通訊作 者.
Jan-Yow Chen, Jiung-Hsiun Liu, Hong-Dar Isaac Wu, Kuo-Hung Lin, KuanCheng Chang, Ying-Ming Liou* (2016, Jul). Transforming Growth Factor-β1 T869C Gene Polymorphism Is Associated with Acquired Sick Sinus Syndrome via Linking a Higher Serum Protein Level. PLOS ONE, 11(7):e0158676.. (SCI, 24/69,MULTIDISCIPLINARY SCIENCES). 本人為通訊

研討會論文

 
*Tsai, DC, SR Shieh, JY Chen, SW Tsai, #YM Liou. 2008/03 A study in vivo with cardio-protection of green tea extracts on rat myocardial infarction induced by coronary ligation,The 23rd Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan, March 17-18, 2008. .
*Li, RY, #YM Liou, TH Ying, Gin-Den Chen, JM Liao, DB Shieh 2008 Involvement of formin-2 expression in tyrosine kinase related cell growth of undifferentiated cultured human umbilical stem cells,The 23rd Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan, March 17-18, 2008. .
#Liou, YM, Watanabe, M, Ishiwata, SI. 2007 Reconstitution of calcium-regulated thin filaments into gelsolin-treated skinned smooth muscle of Taenia Caeci in guinea pigs,The 22th Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan, March 17-18, 2007.
Liou, YM, *SC Kuo 2007 Protective effects of green tea polyphenols of catechin and epigallocatechin-3-gallate on acidic pH reduction of Ca2+ sensitivity of cardiac muscle contraction,The 22nd Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan, March 17-18, 2007.
#Liou, YM, *JS Chen 2006 Age-dependent decreases in the expression levels of mouse brain formin-2. ,The 21st Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan, March 18-19, 2006..
W.Y. Chao, Y.M. Liou#. 2005/03 Study of fluorescence spectroscopy with protein-protein interaction among recombinant chicken skeletal troponin T,troponin C and troponin I The 20th Annual Conferences of Biomedical Science. Taipei, Taiwan, Mar 26-27, 2005. .
Liou, YM, M Watanabe, and S Ishiwata 2005/02 Studies with reconstitution of actin filaments into gelsolin-treated skinned smooth muscle strips of 49th American Biophysical Annual Meeting at Long Beach,CA, USA. , Feb 12-16..
*#Liou, YM, HL Chao. 2005 Effect of calcium and troponin I on the proximity relationship between the central helix of troponin C and the C-terminal end of troponin T,International Symposium Celebrating 40th Anniversary of Troponin Discovery, the 33rd NIPS Conference. Okazaki, JAPAN, October 25-28, 2005.
Liou, YM and JCH Chang. 2004 Differential effect of pH on calcium-induced conformational changes of cardiac troponin C in complex 48th American Biophysical Annual Meeting at Baltimore,MA, USA. , Feb 23-27, 2004. .
Liou, YM and MW Chen 2003 Calcium-Dependent Protein-Protein Interactions Induce Changes in Proximity Relationships of Cys-48 a 4th Eastern Asian Biophysical Symposium,Taipei, Taiwan, Nov. 3-7, 2003.
YP Wen*, JC Cheng, and YM Liou# 2002 Sex effect on troponin I degradation in avian blood serum,Annual Conferences of Biomedical Science..
YC Tseng*, JC Cheng, Y M Liou# 2002 Pyrene exercimer fluorescence assessing proximity changes of Cys-35 and Cys-84 in cardiac troponin C Annual Conferences of Biomedical Scienc.
Liou, Y.M, YC Tseng, JC Cheng 2002 Fluorescence spectroscopy discerning sarcomere length effect on conformational changes of Cys-35 and 46th American Biophysical Annual Meeting,at San Francisco, Ca, USA. , Feb 23-27. .
Cheng, J.C., et al. 2001 Effects of genetic background on myosin isozyme expression and ATPase activity of skeletal muscle in Annual Conferrence of Biomedical Scienc.
Goh, K.-S., et al 2001 Age-dependent polymorphic expression of troponin T in the pectoralis major muscle of domestic chicke Annual Conferrence of Biomedical Scienc.
Liou, YM, and MC Wu 2000 Effects of mechanical influence of varying sarcomere length on sulfhydryl reactivity of cardiac trop Biophys. J. 76: A257.
Goh, K.-S., et al. 2000 Polymorphic expression of myofilament protein troponin I in the pectoralis major muscle of domestic Annual conferrence of Chinese Animal Scienc.

研究計劃

年度
補助機關
計畫名稱
計畫起迄日期
2022
國家科學及技術委員會
探討差異性Akr1A1基因表現對間質幹細胞成脂與成骨分化的影響
2022/08/012023/07/31
2018
科技部
l-caldesmon 蛋白磷酸化對破骨細胞分化的影響
2018/08/012019/07/31
2017
科技部
l-caldesmon 蛋白磷酸化對破骨細胞分化的影響
2017/08/012018/07/31
2016
科技部
l-caldesmon 蛋白磷酸化對破骨細胞分化的影響
2016/08/012017/07/31
2013
科技部
探討gelsolin與caldesmon在TGF-beta訊息傳遞誘導乳癌幹細胞分化形成Invadosome的角色
2013/08/012014/07/31
2012
科技部
探討綠茶多酚在心臟缺血/再灌流傷害的保護機轉
2012/08/012013/07/31
2011
行政院國家科學委員會
綠茶多酚保護心肌傷害壓力下調適心臟細胞誘發程序性細胞死亡的機制探討
2011/08/012012/07/31
2010
行政院國家科學委員會
利用心肌傷害之實驗動物鼠來研究綠茶多酚保護心肌受損的機制探討
2010/08/012011/07/31
2009
行政院國家科學委員會
利用心肌傷害之實驗動物鼠來研究綠茶多酚保護心肌受損的機制探討
2009/08/012010/07/31
2007
行政院國家科學委員會
探討平滑肌細胞內肌動蛋白分子聚合/降解機轉
2007/08/012008/07/31
2006
行政院國家科學委員會
探討平滑肌細胞內肌動蛋白分子聚合/降解機轉
2006/08/012007/07/31
2004
行政院國家科學委員會
肌肉蛋白Troponin I,T,C分子間之交互作用與鈣離子活化肌肉收縮功能之探討
2004/08/012005/07/31