林玉儒 - 助理教授
林玉儒 助理教授 繁體中文 English
專任教師
生醫科技

合成生物學、微生物細胞療法、天然物代謝體學、蛋白質體學

學歷

畢業學校 主修學門系所 學位 時期
國立臺灣大學 生化科技學系所 博士  
國立臺灣大學 植物病理與微生物學系暨研究所 碩士  
東吳大學 微生物學系 學士  

經歷 / 榮譽

服務機關 服務部門 職稱 時期
中央研究院 生物多樣性研究中心 博士後研究員 2016-01~2020-07
美國能源部 Joint Genome institute 訪問學者 2018-01~2018-04
東吳大學 微生物學系 兼任助理教授 108-01~109-07
德國馬克思普朗克研究中心 Max-Planck-Institut für biophysikalische Chemie 訪問學者 2012-08~2013-18

研究方向

My lab focused on working on biopharmaceuticals and synthetic biology. We have established a "Probiotic Factory" platform to produce next generation antibiotics (antimicrobial peptides) or natural products, and to engineer microbial hosts for expressing functional proteins. Our future reaserch intersts to use the genome editing technology and the glycan engineering approach for developing living medicines on pharmaceutical, agriculture and aquaculture.

研究室人員


 

 

期刊論文

 
202301 Yu‐Ju Lin, Jui‐Jen Chang, Huai‐Ting Huang, Chih‐Ping Lee, Yeh‐Fang Hu, Mao‐Lun Wu, Chih‐Yang Huang & Fan‐Hua Nan Improving red‐color performance, immune response and resistance to Vibrio parahaemolyticus on white shrimp Penaeus vannamei by an engineered astaxanthin yeast ,Scientific Reports13:2248
202206 Ganies Riza Aristya, Yu-Ju Lin, Jo-Shu Chang, Jui-Jen Chang, and Hong-Wei Yen Polyhydroxybutyrate (PHB) production from crude glycerol by genetic engineering of Rhodotorula glutinis ,Bioresource Technology Reports18, 101048
202201 Hsiang-Chieh Chuang, Huai-Ting Huang, Novi-Rosmala Dewi, Hsi-Hua Hsiao, Bo-Ying Chen, Zhen-Hao Liao, Meng-Chou Lee, Po-Tsang Lee, Yu-Sheng Wu, Yu-Ju Lin and Fan-Hua Nan Effect of methylmercury exposure on bioaccumulation and nonspecific immune respsonses in Hybrid Grouper Epinephelus fuscoguttatus × Epinephelus lanceolatus ,Animals12, 147
202112 Zaenal Abidin, Huai-Ting Huang, Zhen-Hao Liao, Bo-Ying Chen, Yu-Sheng Wu, Yu-Ju Lin and Fan-Hua Nan Moringa oleifera leaves’extract enhances nonspecific immune responses, resistance against Vibrio alginolyticus, and growth in whiteleg shrimp (Penaeus vannamei) ,Animals12, 42
202111 Novi Rosmala Dewi, Huai-Ting Huang, Yu-Sheng Wu, Zhen-Hao Liao, Yu-Ju Lin, Po-Tsang Lee, Fan-Hua Nan Guava (Psidium guajava) leaf extract enhances immunity, growth, and resistance against Vibrio parahaemolyticus in white shrimp Penaeus vannamei ,Fish & Shellfish Immunology118, 1-10
202108 Huai-Ting Huang, Zhen-Hao Liao, Yu-Sheng Wu, Yu-Ju Lin, Yi Shiun Kang, Fan-Hua Nan Effects of Bidens alba and Plectranthus amboinicus dietary supplements on nonspecific immune responses, growth, and resistance to Vibrio alginolyticus in white leg shrimp (Penaeus vannamei) ,Aquaculture
202106 Dillirani Nagarajan, Ganies Riza Aristya, Yu-Ju Lin, Jui-Jen Chang, Hong-Wei Yen and Jo-Shu Chang Microbial cell factories for the production of polyhydroxyalkanoates ,Essays in Biochemistry
202105 Zhen-Hao Liao, María Joaquina Ibarra-Arana, Jian-Cheng Chen, Huai-Ting Huang, Yu-Ju Lin, Fan-Hua Nan The effects of dietary supplement of Ulva fasciata, fermented soybean and probiotics on the growth of Apostichopus japonicus ,Aquaculture Nutrition
202005 Ming-Hsuan Lee, Tsui-Ling Hsu, Jinn-Jy Lin, Yu-Ju Lin, Yi-Ying Kao, Jui-Jen Chang, Wen-Hsiung Li Constructing a human complex type N-linked glycosylation pathway in Kluyveromyces marxianus ,PLOS ONE15(5): e0233492
202001 Anandharaj M, Lin YJ, Rani RP, Nadendla EK, Ho MC, Huang CC, Cheng JF, Chang JJ, Li WH Constructing a yeast to express the largest cellulosome complex on the cell surface. ,Proc Natl Acad Sci U S Apnas.1916529117
201912 Chia-Hua Lin, Chia-Yen Lu, Ann-Tze Tseng, Chien-Jui Huang, Yu-Ju Lin, and Chao-Ying Chen The ptsG Gene Encoding the Major Glucose Transporter of Bacillus cereus C1L Participates in Root Colonization and Beneficial Metabolite Production to Induce Plant Systemic Disease Resistance ,Molecular Plant-Microbe InteractionsVol. 33, No. 2, 2020, pp. 256–271.
201911 Chung-Chih Tseng, Yu-Ju Lin, Wangta Liu, Hao-Yeh Lin, Hsin-Yu Chou, Caroline Thia, Jou Hsien Wu, Jo-Shu Chang, Zhi-Hong Wen, Jui-Jen Chang, Hui-Min David Wang Metabolic engineering probiotic yeast produces 3S, 3′S-astaxanthin to inhibit B16F10 metastasis ,Food and Chemical Toxicology135: 110993
201909 Hsien‐Lin Liu, Jui‐Jen Chang, Caroline Thia, Yu‐Ju Lin, Shou‐Chen Lo, Chieh‐Chen Huang and Wen‐Hsiung Li Characterizing an engineered carotenoid-producing yeast as an anti-stress chassis for building cell factories ,Microbial Cell Factories18: 155
201806 J. J. Chang, M. Anandharaj, C. Y. Ho, K. Tsuge, T. Y. Tsai, H. M. Ke, Y. J. Lin, M. D. Ha Tran, W. H. Li, C. C. Huang. Biomimetic strategy for constructing Clostridium thermocellum cellulosomal operons in Bacillus subtilis. ,Biotechnology for Biofuels11:157
201806 Hong-Wei Pi, Marimuthu Anandharaj, Yi-Ying Kao, Yu-Ju Lin, Jui-Jen Chang & Wen-Hsiung Li. Engineering the oleaginous red yeast Rhodotorula glutinis for simultaneous β-carotene and cellulase production. ,Scientific Reports8:10850
201805 Ming-Hsuan Lee, Jinn-Jy Lin, Yu-Ju Lin, Jui-Jen Chang, Huei-Mien Ke, Wen-Lang Fan, Tzi-Yuan Wang & Wen-Hsiung Li. Genome-wide prediction of CRISPR/Cas9 targets in Kluyveromyces marxianus and its application to obtain a stable haploid strain. ,Scientific Reports9;8(1):7305
201711 Yu-Ju Lin*, Jui-Jen Chang, Chyi-How Lay, Caroline Thia, Yueh-Chin Wu, Yu-Han Hou, Chieh-Chen Huang, and Wen-Hsiung Li. Constructing a Cellulosic Yeast Host with an Efficient Cellulase Cocktail. ,Biotechnology and Bioengineering115:751-761
201707 Lin Y. J., Chang J.-J, Lin H. Y., Thia C., Kao Y. Y, Huang C.-C., and Li W.-H. Metabolic engineering a yeast to produce astaxanthin. ,Bioresource Technology245:899-905
201508 Yu-Ju Lin, Wen-Ti Liu, Holger Stark, Ching-Tsan Huang Expression of enterovirus 71 virus-like particles in transgenic enoki (Flammulina velutipes). ,Applied Microbiology and Biotechnology99(16):6765-74
201303 Yu-Ju Lin, Li-Hsin Huang, Ching-Tsan Huang Enhancement of Heterologous Gene Expression in Flammulina velutipes Using Polycistronic Vectors Containing a Viral 2A Cleavage Sequence ,PLoS ONE8(3): e59099
201005 Huang C, Yang KH, Liu YH, Lin YJ, and Chen CY Suppression of southern corn leaf blight by a plant growth promoting rhizobacterium Bacillus cereus C1L ,Annals of Applied Biology157: 45-53
200912 Yu-Ju Lin;Yen-Ting Wang;Hong-Ren Yang;Pi-Han Wang Detection of quiescent infection of mango stem end rot pathogen Lasiodiplodia theobromae in shoot and pre-plucked mango fruit by seminested PCR ,Plant Pathology Bulletin18(4): 225-235
200910 Huang Chien-Jui, Shu-Huei Guo, Shu-Chun Chung, Yu-Ju Lin, Chao-Ying Chen Analysis of the Involvement of Chitin-Binding Domain of ChiCW in Antifungal Activity, and Engineering a Novel Chimeric Chitinase with High Enzyme and Antifungal Activities ,Journal of Microbiology and Biotechnology19(10):1169-75

專利

 
Jui-Jen Chang, Caroline Thia, Hao-­Yeh Lin, Yu-­Ju Lin, Chieh-­Chen Huang, and Wen-­Hsiung Li RECOMBINANT POLYNUCLEOTIDE SEQUENCE FOR PRODUCING ASTAXANTHIN AND USES THEREOF,PCT/US15/31273.
張瑞仁 CHANG, JUI JEN; 王惠民 WANG, HUI MIN; 林玉儒 LIN, YU JU; 周鑫佑 CHOU, HSING YU; 林浩業 LIN, HAO YEH; 黃俊穎 HUANG, JYUN YING; 程凱若 THIA, CAROLINE; 劉力衡 LIU, LI HENG USE OF ASTAXANTHIN FOR MANUFACTURING COMPOSITIONS FOR INHIBITING OR TREATING SKIN DISORDERS,201938139.
張瑞仁 CHANG, JUI-JEN; 程凱若 THIA, CAROLINE; 林浩業 LIN, HAO-YEH; 林玉儒 LIN, YU-JU; 黃介辰 HUANG, CHIEH-CHEN; 李文雄 LI, WEN-HSIUNG 用以製備蝦紅素之重組多核苷酸序列及其用途,I681052.

研究計劃

年度
補助機關
計畫名稱
計畫起迄日期
2022
國家科學及技術委員會
建構功能性水產益生菌高通量篩選平台及其精準抗病基因編輯技術開發
2022/08/012023/07/31
2022
行政院農業委員會漁業署
臺灣蝦類產業發展與輔導計畫
2022/01/012022/12/31
2022
其他公司
檢測類胡蘿蔔素
2022/01/012022/12/31
2021
行政院農業委員會漁業署
臺灣蝦類產業發展與輔導計畫
2021/01/012021/12/31
2021
行政院農業委員會漁業署
建立白蝦區域病原檢測站計畫
2021/08/012021/12/31
2021
國家科學及技術委員會
以細胞免疫活性建構水產益生菌篩選平台及其功能性細胞編輯技術開發
2021/03/012022/07/31
2021
全瑩生技股份有限公司
蝦紅素生產菌株基因轉殖優化
2021/10/222022/02/28