Lai, Tsai-Chun  - Assistant professor
Lai, Tsai-Chun Assistant professor 繁體中文 English
Full-time teacher

Vascular Physiology, Inflammation, Air Pollutant PM2.5, Oxidative Stress, Mitochondrial Fission, Autophagy, Reprodictive Endocrinology, Adipose-Derived Stem Cells.



Graduated from Major in Degree Period
National Taiwan University Graduate Institute of Physiology PhD 2011.09~2018.06
National Taiwan University Graduate Institure of Physiology MS 2009.09~2011.06
National Chung Hsing University Department of Life Sciences BS 2005.09~2009.06

Experience / Honor

Organization Department Title Period
National Chung Hsing University Department of Life Science Assitant Professor 2023.02~
National Taiwan University Graduate Institute of Anatomy and Cell Biology Post-doctral research 2019.11~2023.01



Research topic: air pollutant-particulate matter (PM2.5)-related studies

  • The combined effect of PM2.5 and other metabolic diseases on cardiovascular disease:related machnisms of oxidative stress, mitochondrial fission and mitophagy on endothelial inflammation.
  • The effect of PM2.5 on endocrine and reproductive system:role of mitochodial fission, mitophagy and autophagy on steriodogenesis.
  • Seek for the effective and potential drugs for amelioration of these diseases.
  • Any novel ideas are welcome to discuss with me!

Weclome to join us~

Journal Article

Lai TC*, Lee CW, Hsu MH, Chen YC, Lin SR, Lin SW, Lee TL, Lin SY, Hsu SH, Tsai JS, Chen YL. 2023/12 Nanocurcumin Reduces High Glucose and Particulate Matter-Induced Endothelial Inflammation: Mitochondrial Function and Involvement of miR-221/222. International Journal of Nanomedicine. 18:7379-7402. [IF: 8.0; Pharmacology & pharmacy, 17/278=6.12%; Q1]. (SCI)
Kuo YH, Lai TC*, Chang CH, Hsieh HC, Yang FM, Hu MC. 2023/08 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole (DRB) induces apoptosis in breast cancer cells through inhibiting of Mcl-1 expression. Scientific Reports. 13(1):12621. [IF: 4.6; Multidisciplinary sciences, 22/73=30.14%; Q2]. (SCI)
Lai TC*, Chen YC, Cheng HH, Lee TL, Tsai JS, Lee IT, Peng KT, Lee CW, Hsu LF, Chen YL. 2022/03 Combined exposure to fine particulate matter and high glucose aggravates endothelial damage by increasing inflammation and mitophagy: the involvement of vitamin D. Particle and Fibre Toxicology. 19:25. [IF: 9.112; Toxicology, 4/94=4.25%; Q1]. (SCI)
Chen YC, Sung HC, Chuang TY, Lai TC*, Lee TL, Lee CW, Lee IT, Chen YL. 2021/07 Vitamin D(3) decreases TNF-ɑ-induced inflammation in lung epithelial cells through a reduction in mitochondrial fission and mitophagy. Cell Biology and Toxicology. 1-24. [IF: 6.819; Toxicology, 9/94=9.57%; Q1]. (SCI)
Lee TL, Lai TC*, Lin SR, Lin SW, Chen YC, Pu CM, Lee IT, Tsai JS, Lee CW, Chen YL. 2021/01 Conditioned medium from adipose-derived stem cells attenuates ischemia/reperfusion-induced cardiac injury through the microRNA-221/222/PUMA/ETS-1 pathway. Theranostics. 11(7):3131-3149. [IF: 11.60; Medicine, research & experimental, 13/140=9.28%; Q1]. (SCI)
Lai TC*, Lee TL, Chang YC, Chen YC, Lin SR, Lin SW, Pu CM, Tsai JS, Chen YL. 2020/12 MicroRNA-221/222 Mediates ADSC-Exosome-Induced Cardioprotection Against Ischemia/Reperfusion by Targeting PUMA and ETS-1. Frontiers in Cell and Developmental Biology. 8:569150. [IF: 6.08; Developmental biology, 6/40=15.00%; Q1]. (SCI)
Lee TL, Lee MH, Chen YC, Lee YC, Lai TC*, Lin HY, Hsu LF, Sung HC, Lee CW, Chen YL. 2020/12 Vitamin D Attenuates Ischemia/Reperfusion-Induced Cardiac Injury by Reducing Mitochondrial Fission and Mitophagy. Frontiers in Pharmacology. 11:604700. [IF: 5.98; Pharmacology & pharmacy, 50/279=17.92%; Q1]. (SCI)
Chen YC, Chuang TY, Liu CW, Liu CW, Lee TL, Lai TC*, Chen YL. 2020/08 Particulate matters increase epithelial-mesenchymal transition and lung fibrosis through the ETS-1/NF-ĸB-dependent pathway in lung epithelial cells. Particle and Fibre Toxicology. 17(1):41. [IF: 9.112; Toxicology, 4/94=4.25%; Q1]. (SCI)
Lai TC*, Hu MC. 2019/03 Regulation of liver receptor homologue-1 by DDB2 E3 ligase activity is critical for hepatic glucose metabolism. Scientific reports. 9(1):5304. [IF: 4.997; Multidisciplinary sciences, 19/73=26.03%; Q2]. (SCI)
Lai TC*, Li HF, Li YS, Hung PY, Shyu MK, Hu MC. 2017/06 Proximal GATA-binding sites are essential for human HSD3B1 gene transcription in the placenta. Scientific reports. 7(1):4271. [IF: 4.997; Multidisciplinary sciences, 19/73=26.03%; Q2]. (SCI)
Yang FM, Feng SJ, Lai TC*, Hu MC. 2015/10 A calreticulin-dependent nuclear export signal is involved in the regulation of liver receptor homologue-1 protein folding. Biochemical Journal. 471(2):199-209. [IF: 3.76; Biochemistry & molecular biology, 175/297=57.23%]. (SCI)

Research Project

2023 NSTC To evaluate the effect of particulate matter and high glucose on endothelial injury: the role of mitochondrial fission and mitophagy 2023/08/01-2024/07/31