學歷
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畢業學校
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主修學門系所
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學位
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時期
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美國加州大學戴維斯分校
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微生物學系
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博士
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2021
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國立中興大學
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生物科技學研究所
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碩士
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2012
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國立中興大學
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植物病理學系
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學士
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2010
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經歷 / 榮譽
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服務機關
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服務部門
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職稱
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時期
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中興大學
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微生物暨公共衛生學研究所
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博士後研究員
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2021-2023
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美國USDA
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National Institute of Food and Agriculture
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Pre-doctoral計畫主持人
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2019-2021
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美國UC Irvine
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生物安全第三等級處 (BSL3)
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Trainee and Trainer
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2015-2021
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研究方向
1. 病原菌-宿主交互作用 (Microbe-Host interaction)
我的研究團隊專注於探討細菌性病原菌如何操控宿主的先天免疫系統，以促進其存活的制病機制。本實驗室使用的病原菌是單核細胞增生李斯特菌（Listeria monocytogenes）。此菌若感染於兒童、老年人或免疫功能低下的個體，較可能導致嚴重且危及生命的症狀。此外，感染李斯特菌之懷孕婦女常造成不良妊娠結果，如引發流產或新生兒感染等。本研究室針對孕期間李斯特菌感染的分子機制，希望藉由解析李斯特菌與宿主之間的交互作用，幫助我們了解細菌病原體如何利用毒力因子破壞宿主防禦反應與胎盤相關之病理。
2. 環境污染-宿主交互作用 (Environment pollutant-host interaction)
全球大量生產的塑膠已導致微米級和奈米級塑膠顆粒成為嚴重的環境污染來源。近期研究顯示，這些塑膠顆粒能在多種人體組織中累積並引發細胞毒性。本研究室聚焦在塑膠污染導致的孕期併發症、探討塑膠微粒對胎盤功能的損害及其導致妊娠併發症的分子機制。我們結合細胞實驗、動物模型及人類胎盤組織分析，解析塑膠微粒對胎盤免疫功能及屏障功能的破壞機制。希望提升大眾對塑膠污染健康風險的認識，且減輕與塑膠相關的生殖危害。
研究室人員
期刊論文
Liu YC, Liao GR, Tsai AY, Kuan CY , Tseng CY , Tsai RS, Albrecht RA , Kuo RL, Cheng IC, Liang WT, Ou SC, Hsu WL. NS2 is a key determinant of compatibility in reassortant avian influenza virus with heterologous H7N9 derived NS segment. 2022. Virus Research. Vol. 324
Tsai AY*, Byndloss MX*, Seyffert N, Winter MG, Young BM, Tsolis RM. Tumor necrosis factor α (TNF-α) contributes to inflammatory pathology in the placenta during Brucella. 2022. Infection and Immunity. Vol. 90
Tsai AY, English BC, Tsolis RM. Hostile takeover: hijacking of endoplasmic reticulum function by T4SS and T3SS effectors creates a niche for intracellular pathogens. 2019. Microbiology Spectrum. Vol. 7
Byndloss MX*, Tsai AY*, Miller CN, Young BM, Seyffert N, Kerrinnes T, de Jong MF, Winter MG, Walker GT, Celli J, Tsolis RM. Brucella abortus infection of placental trophoblasts triggers ER stress-mediated cell death and fetal loss via T4SS-dependent activation of CHOP. 2019. mBio. Vol. 10
Chen IH, Tsai AY, Huang YP, Wu IF, Cheng SF, Hsu YH, Tsai CH. Nuclear-encoded pastidal carbonic anhydrase is involved in replication of Bamboo mosaic virus RNA in Nicotiana benthamiana. 2017. Frontiers in Microbiology. Vol. 8.
Keestra-Gounder AM, Byndloss MX, Seyffert N, Young BM, Chávez-Arroyo A, Tsai AY, Cevallos SA, Winter MG, Pham OH, Tiffany CR, de Jong MF, Kerrinnes T, Ravindran R, Luciw PA, McSorley SJ, Bäumler AJ, Tsolis RM. NOD1 and NOD2 signalling links ER stress with inflammation. 2016. Nature. Vol. 532
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