學歷
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畢業學校
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主修學門系所
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學位
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時期
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美國加州大學戴維斯分校
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微生物學系
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博士
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2021
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國立中興大學
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生物科技學研究所
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碩士
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2012
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國立中興大學
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植物病理學系
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學士
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2010
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經歷 / 榮譽
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服務機關
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服務部門
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職稱
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時期
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中興大學
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微生物暨公共衛生學研究所
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博士後研究員
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2021-2023
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美國USDA
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National Institute of Food and Agriculture
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Pre-doctoral計畫主持人
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2019-2021
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美國UC Irvine
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生物安全第三等級處 (BSL3)
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Trainee and Trainer
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2015-2021
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研究方向
Research Interests: host-pathogen interaction
Our group focuses on basic mechanisms by which bacterial pathogens can manipulate the host’s innate immune system for survival. The model organism utilized in the lab is Listeria monocytogenes, an intracellular pathogen that has been shown as a great model organism to study molecular biology. Elucidating the interaction of L. monocytogenes and the host enables us to uncover new principles of how bacterial pathogens deploy virulence factors to undermine the host defense responses.
L. monocytogenes infection in children, elderly or immunocompromised individuals could experience severe, life-threatening symptoms. Further, neonatal infections caused by L. monocytogenes in pregnant women could lead to adverse pregnancy outcomes.
Our research interrogates the molecular mechanisms of L. monocytogenes infection during pregnancy, a work that also has implications for understanding other placental pathologies.
研究室人員
期刊論文
Liu YC, Liao GR, Tsai AY, Kuan CY , Tseng CY , Tsai RS, Albrecht RA , Kuo RL, Cheng IC, Liang WT, Ou SC, Hsu WL. NS2 is a key determinant of compatibility in reassortant avian influenza virus with heterologous H7N9 derived NS segment. 2022. Virus Research. Vol. 324
Tsai AY*, Byndloss MX*, Seyffert N, Winter MG, Young BM, Tsolis RM. Tumor necrosis factor α (TNF-α) contributes to inflammatory pathology in the placenta during Brucella. 2022. Infection and Immunity. Vol. 90
Tsai AY, English BC, Tsolis RM. Hostile takeover: hijacking of endoplasmic reticulum function by T4SS and T3SS effectors creates a niche for intracellular pathogens. 2019. Microbiology Spectrum. Vol. 7
Byndloss MX*, Tsai AY*, Miller CN, Young BM, Seyffert N, Kerrinnes T, de Jong MF, Winter MG, Walker GT, Celli J, Tsolis RM. Brucella abortus infection of placental trophoblasts triggers ER stress-mediated cell death and fetal loss via T4SS-dependent activation of CHOP. 2019. mBio. Vol. 10
Chen IH, Tsai AY, Huang YP, Wu IF, Cheng SF, Hsu YH, Tsai CH. Nuclear-encoded pastidal carbonic anhydrase is involved in replication of Bamboo mosaic virus RNA in Nicotiana benthamiana. 2017. Frontiers in Microbiology. Vol. 8.
Keestra-Gounder AM, Byndloss MX, Seyffert N, Young BM, Chávez-Arroyo A, Tsai AY, Cevallos SA, Winter MG, Pham OH, Tiffany CR, de Jong MF, Kerrinnes T, Ravindran R, Luciw PA, McSorley SJ, Bäumler AJ, Tsolis RM. NOD1 and NOD2 signalling links ER stress with inflammation. 2016. Nature. Vol. 532
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