Lin, Ho - Professor
Lin, Ho Professor 繁體中文 English
Full-time teacher

Cell Biology, Tumor Biology, Physiology, Endocrinology, Neurobiology


Graduate from Major in Degree Period
National Yang Ming University, Taiwan Department of Physiology Ph.D. 1995 ~ 2000
Tunghai University, Taiwan Department of Biology B.S. 1991 ~ 1995

Experience / Honor

Organization Department Title Period
University of Texas Southwestern Medical Center Urology Visiting Professor 2012.02 - 2013.01
Journal "Adaptive Medicine" Editorial Board Associate Editor 2011.01-2012.12
National Chung Hsing University Department of Life Sciences Associate Professor 2009.02 to date
Society of Adaptative Science in Taiwan council member of council 2007 to date
National Chung Hsing University, Taiwan Department of Life Science Assistant Professor 2004.10~2009.01
National Health Research Institutes, Taiwan Division of Molecular and Genomic Medicine Postdoctoral Fellow 2000~2004


Research Interest
1 Signal transduction of tumor cells and drug effects
2 Cellular signal transduction in endocrinology
3 Molecular mechanism of neuronal differentiation (including neurodegenerative diseases)

Research Topic
1 Causes of cancers and their responses to drugs
2 Mechanisms of steroidogenesis and drug effects

Current Research Grant
1. Taiwan Ministry of Science and Technology
2. Taichung Veterans General Hospital

Lab Member

The current lab members include postdoctoral fellows, Ph.D. students, research assistants, master degree students, undergraduate students, high school students.

Anyone who is interested to join my lab is welcome to contact me at any time.

The foreign students, including graduate or undergraduate exchange student, are welcome to join our lab. We provide the different kinds of scholarship and the opportunity of research/teach assistant to support the living cost.

Journal Article

Lin LC, Gao AC, Lai, CH*, Hsieh JT*, and Lin H* 2017/01 Induction of neuroendocrine differentiation in castration resistant prostate cancer cells by adipocyte differentiation-related protein (ADRP) delivered by exosomes.,Cancer Letters. vol.391, no.74-82. (SCI)
Chen YA, Lien HM, Kao MC, Lo UG, Lin LC, Lin CJ, Chang SJ, Chen CC, Hsieh JT*, Lin H*, Tang CH*, and Lai CH* 2017/01 Sensitization of radioresistant prostate cancer cells by resveratrol isolated from Arachis hypogaea stems.,PLoS One. vol.12, pp.e0169204. (SCI)
Huang PH, Chen MC, Peng YT, Kao WH, Chang CH, Wang YC, Lai CH, Hsieh JT, Wang JH, Lee YT, Lin E, Yue CH, Wang HY, You SC, Lin H* 2016/12 Cdk5 directly targets nuclear p21CIP1 and promotes cancer cell growth, Cancer Research . vol.76, pp.6888-6900. (SCI)
Lai CK, Chen YA, Lin CJ, Lin HJ, Kao MC, Huang MZ, Lin YH, Chiang-Ni C, Chen CJ, Lo 2016/02 Molecular mechanisms and potential clinical applications of Campylobacter jejuni cytolethal distending toxin, Frontiers in Cellular and Infection Microbiology. vol.6, no.9. (SCI)
Hsiao HB, Hsieh CC, Wu JB, Lin H, and Lin WC* 2016/02 Kinsenoside inhibits the inflammatory mediator release in a type-II collagen induced arthritis mouse model by regulating the T cells response,BMC Complementary and Alternative Medicine. vol.16, no.80. (SCI)
Huang PH, Wang HY, Huang CC, Lee YT, Yue CH, Chen MC*, Lin H* 2016 Suppression of breast cancer cell growth by Her2-reduced AR serine 81 phosphorylation, Chinese Journal of Physiology. (SCI)
Lin CJ, Lai CK, Kao MC, Wu LT, Lo UG, Lin LC, Chen YA, Lin H*, Hsieh JT*, Lai CH*, Lin 2015/06 Impact of cholesterol on disease progression,Biomedicine. vol.5, no.7. (SCI)
Yue CH, Huang CY, Tsai JH, Hsu CW, Hsieh YH*, Lin H*, Liu JY* 2015/05 MZF-1/Elk-1 complex binds to protein kinase Cα promoter and is involved in hepatocellular carcinoma,PLoS One. vol.10, no.5. (SCI)
Lin HY, Huang BR, Yeh WL, Lee CH, Huang SS, Lai CH, Lin H, and Lu DY 2014/02 Antineuroinflammatory effects of lycopene via activation of adenosine monophosphate-activated protein kinase-α1/heme oxygenase-1 pathways,Neurobiology of Aging. vol.35, no.191-202. (SCI)
Chen MC, Hsu SL, Lin H*, and Yang TY* 2014 Retinoic acid and cancer treatment,Biomedicine. vol.4, no.4, pp.22. (SCI)
Shen SC, Shen CI, Lin H, Chen CJ, Chang CY, Chen SM, Lee HC, Lai PS, and Su HL* 2014 Susceptibility of human embryonic stem cell-derived neural cells to Japanese encephalitis ,PLoS One. vol.9, no.12. (SCI)
Lin E, Chen MC, Huang CY, Hsu SL, Huang WJ, Lin MS, Wu JCH, Lin H* 2014 All-trans retinoic acid induces DU145 cell cycle arrest through Cdk5 activation,Cellular Physiology and Biochemistry. vol.33, pp.1620-1630. (SCI)
Hsu FN, Chen MC, Lin KC, Peng YT, Li PC, Lin E, Chiang MC, Hsieh JT, and Lin H* 2013 Cyclin-dependent kinase 5 modulates STAT3 and androgen receptor activation through phosphorylation of Ser727 on STAT3 on prostate cancer cells,American Journal of Physiology-Endocrinology and Metabolism. vol.305, pp.E975-E986. (SCI)
Huang PH, Huang CY, Chen MC, Lee YT, Yue CH, Wang HY, and Lin H* 2013 Emodin and aloe-emodin suppress breast cancer cell proliferation through ERα inhibition,Evidence-based Complementary and Alternative Medicine. vol.2013, pp.376123. (SCI)
Hsiao HB, Lin H, Wu JB, and Lin WC 2013 Kinsenoside prevents ovariectomy-induced bone loss and suppresses osteoclastogenesis by regulating classical NF-κB pathways,Osteoporosis International, 24. pp.1663-1676. (SCI)
Lin E, Lin H, Hung GU, Wu JCH, Hsieh HL, Lin TC, Chen CC, Wang CH, Lin MS 2013 Spontaneous rupture of the bladder after a seizure,a pitfall of diagnosis. Surgical Science, 4.
Wang HY, Lin WY, Chen MC, Lin T, Chao CH, Hsu FN, Lin E, Huang CY, Luo TY, and Lin H* 2013 Inhibitory effects of Rhenium-188-labeled Herceptin on prostate cancer cell growth,a possible radioimmunotherapy to prostate carcinoma. International Journal of Radiation Biology, 89. no.1 , pp.346-355 . (SCI)
Chen MC, Huang CY, Hsu SL, Lin E, Ku CT, Lin H*, and Chen CM* 2012 Retinoic acid induces apoptosis of prostate cancer DU145 cells through Cdk5 over-activation, ECAM, 2012: 580736 . no.1. (SCI)
Lin HY, Yeh WL, Huang BR, Lin C, Lai CH, Lin H*, and Lu DY* 2012 Desipramine protects neuronal cell death and induces heme oxygenase-1 expression in Mes23.5 dopaminergic neurons,PLoS One, 7: e50138 . (SCI)
Lin H and Wang PS 2012 Inhibitory effects of digoxin on testosterone production in rat Leydig cells,Adaptive Medicine, 4. pp.165-172 .
Chang CT, Ho TY, Lin H, Liang JA, Huang HC, Li CC, Lo HY, Wu SL, Huang YF, and Hsiang CY 2012 5-Fluorouracil induced intestinal mucositis via nuclear Factor-kappaB activation by transcriptomic analysis and in vivo bioluminescence imaging,PLoS One, 7: e31808 . (SCI)
Lee YT*, Lin H, Guo JC, Yan SL, Hou HJ, Lai YS, Liu YH, Wu HS, and Hwang MH 2012 Laparoscopy-assisted Billroth I gastrectomy for ectopic pancreas in the prepyloric region,Case Report of Gastroenterology, 6. pp.712-719 .
Hsu FN, Chen MC, Chiang MC, Lin E, Lee YT, Huang PH, Lee GS, Lin H* 2011 Regulation of androgen receptor and prostate cancer growth by cyclin-dependent kinase 5,Journal of Biological Chemistry, 286. pp.33141-33149. (SCI)
Hsiao HB, Wu JB, Lin H, Lin WC*. 2011 Kinsenoside isolated from Anoectochilus formosanus suppresses lipopolysaccharide-stimulated inflammatory reactions in macrophages and endotoxin shock in mice,Shock, 35. pp.184-190.
Chang CT, Lin H, Ho TY, Li CC, Lo HY, Wu SL, Huang YF, Liang JA, Hsiang CY 2011 Comprehensive assessment of host responses to ionizing radiation by nuclear factor-κB bioluminescence imaging-guided transcriptomic analysis,PLoS One, 6: e23682 . pp.IF: 4.092. 14.1%. (SCI)
Hsu FN, Yang MS, Lin E, Tseng CF, Lin H*. 2011 The significance of Her2 on androgen receptor protein stability in the transition of androgen requirement in prostate cancer cells,American Journal of Physiology-Endocrinology and Metabolism, 300. pp.E902-E908 .
Lien HM, Kuo PT, Huang CL, Kao JY, Lin H, Yang DY, Lai YY. 2011 Study of the anti-proliferative activity of 5-substituted 4,7-dimethoxy-1,3-benzodioxole derivitives of SY-1 from Antrodia camphorate on human COLO 205 colon cancer cells, ECAM, 2011: 450526 . no.1. (SCI)
Chen CH, Lin H, Chuang SM, Lin SY, Chen JJW 2010 Acidic stress facilitates tyrosine phosphorylation of HLJ1 to associate with actin cytoskeleton in lung cancer cells,Experimental Cell Research, 316:. pp.2910-2921 .
Lee YT, Lin H, Chen KY, Wu HS, Hwang MH, Yan SL 2010 Life-threatening hemobilia caused by hepatic pseudoaneurysm after T-tube choledochostomy: report of a case,BMC Gastroenterology, 10: 81.
Chen MC, Lin H, Hsu FN, Huang PH, Lee GS, Wang PS 2010 The involvement of cAMP in nerve growth factor-triggered p35/Cdk5 activation and differentiation in PC12 cells,American Journal of Physiology-Cell Physiology. pp.C516-C527. (SCI)
Kuo HS, Hsu, FN, Chiang MC, You SC, Chen MC, Lo MJ, and Lin H* 2009 Retinoic acid causes Cdk5-dependent apoptosis of cervical cancer cell line,Chinese Journal of Physiology, 52. pp.23-30. (SCI)
Lin H*, Chen MC, and Ku CT 2009 Cdk5 regulates steroidogenic acute regulatory protein (StAR) and androgen production in mouse Leydig cells Endocrinology, 150,pp.396-403 . (SCI)
Lin H 2009 The versatile roles of cyclin-dependent kinase 5 in human diseases,Adaptive Medicine, 1. pp.22-25.
Lee WJ, Wu CS, Lin H, Lee IT, Wu CM, Tseng JJ, Chou MM, and Sheu WHH 2009 Visfatin-induced expression of inflammatory mediators in human endothelial cells through the NF-kB pathway Internatioanl Journal of Obesity 33,pp.465-472. (SCI)
Yan SL, Lin H, Kuo CL, Wu HS, Huang MH, and Lee YT 2008 Primary retroperitoneal mucinous cystadenoma,report of a case and review of the literature World Journal of Gastroenterology, 14. pp.5769-5772 .
Lee YT, Lin H, Wu HS, Kuo CL, Hwang MA, Tseng YC, and Hwang MH 2008 Large epidermoid cyst of the breast: report of a case Formosan Journal of Surgery 41,pp.221-225. (SCI)
Lin E, Lin H, Lin MS, Wu JCH, Chen WC, Chiu AW 2008 Laparoscopic excision of a paraganglioma located in the renal arteriovenous windows-a reasonable approach ,The Open Urology & Nephrology Journal, 1. pp.40-43.
Lin H*, Chen MC, Chiu CY, Song YM, and Lin SY 2007 Cdk5 regulates STAT3 activation and cell proliferation in medullary thyroid carcinoma cells,Journal of Biological Chemistry 282. pp.2776-2784 . (SCI)
Lin H, Lin TY, and Juang JL*. 2007 Abl deregulates Cdk5 kinase activity and subcellular localization for amyloid-induced Drosophila neu Cell Death & Differentiation 14,pp.607-615 . (SCI)
Lin H, Juang JL*, and Wang PS* 2004 Involvement of Cdk5/p25 in digoxin-triggered prostate cancer cell apoptosis. Journal of Biological Chemistry 279,pp.29302-29307 . (SCI)
Lin H, Wang SW, Wang RY, and Wang PS*. 2001 Stimulatory effect of lactate on testosterone production by rat Leydig cells,Journal of Cellular Biochemistry 83. pp.147-154 . (SCI)
Lin H, Chien CH, Lin YL, Chen CF, and Wang PS*. 2000 Inhibition of testosterone secretion by S-petasin in rat testicular interstitial cells,Chinese Journal of Physiology 43. pp.99-103 . (SCI)
Chiao YC, Lin H, Wang SW, and Wang PS*. 2000 Direct effects of propylthiouracil on testosterone secretion in rat testicular interstitial cells,British Journal of Pharmacology 130. pp.1477-1482 . (SCI)
Chang LL, Lo MJ, Kan SF, Huang WJ, Chen JJ, Kau MM, Wang JL, Lin H, Tsai SC, Chiao YC, Yeh JY, Wun WS, and Wang PS* 1999 Direct effects of prolactin on corticosterone release by zona fasciculata-reticularis cells from mal Journal of Cellular Biochemistry 73,pp. 563-572 . (SCI)
Lin H, Tsai SC, Chen JJ, Chiao YC, Wang SW, Wang GJ, Chen CF, and Wang PS*. 1999 Effects of evodiamine on the secretion of testosterone in rat testicular interstitial cells,Metabolism 48. pp.1532-1535 . (SCI)
Huang WJ, Yeh JY, Tsai SC, Lin H, Chiao YC, Chen JJ, Lu CC, Hwang SW, Wang SW, Chang LS, and Wang PS*. 1999 Regulation of testosterone secretion by prolactin in male rats,Journal of Cellular Biochemistry 74. pp.111-118 . (SCI)
Kau MM, Lo MJ, Wang SW, Tsai SC, Chen JJ, Chiao YC, Yeh JY, Lin H, Shum AY, Fang VS, Ho LT, and Wang PS*. 1999 Inhibition of aldosterone production by testoterone in male rats.,Metabolism 48. pp.1108-1114 . (SCI)
Lo MJ, Kau MM, Chen JJ, Yeh JY, Lin H, Wang SW, and Wang PS 1999 Age-related differences in corticosterone secretion in female rats,Metabolism 48. pp.535-541 . (SCI)
Kau MM, Lo MJ, Tsai SC, Chen JJ, Lu CC, Lin H, Wang SW, and Wang PS*. 1999 Effects of estradiol on aldosterone secretion in ovariectomized rats,Journal of Cellular Biochemistry 73. pp.137-144 . (SCI)
Wang SW, Lin H, Hwang WJ, and Wang PS* 1999 Inhibition of testosterone secretion by digitoxin in rat testicular interstitial cell,Journal of Cellular Biochemistry 74. pp.74-80 . (SCI)
Lin H, Wang SW, Tsai SC, Chen JJ, Chiao YC, Lu CC, Huang WJ, Wang GJ, Chen CF and Wang PS* 1998 Inhibitory effect of digoxin on testosterone secretion through mechanisms involving decreases of cyc British Journal of Pharmacology 125,pp.1635-1640 . (SCI)
Wang SW, Lin H, Tsai SC, Hwu CM, Chiao YC, Lu CC, Chen JJ, Wang GJ, Chou CJ, Lin LC, and Wang PS*. 1998 Effects of methanol extract of Chansu on the hypothalamic-pituitary-testis function in rats,Metabolism 47. pp.1211-1216 . (SCI)
Doong ML, Lu CC, Kau MM, Tsai SC, Chiao YC, Chen JJ, Yeh JY, Lin H, Huang SW, Chen TS, Chang FY, and Wang PS* 1998 Inhibition of gastric emptying and intestinal transit by amphetamine through a mechanism involving a British Journal of Pharmacology 124,pp.1123-1130 . (SCI)
Tsai SC, Chen JJ, Chiao YC, Lu CC, Lin H, Yeh JY, Lo MJ, Kau MM, Wang SW, and Wang PS*. 1997 The role of cyclic AMP production,calcium channel activation and enzyme activities in the inhibitio British Journal of Pharmacology 122. pp.949-955 . (SCI)
Wang SW, Chiao YC, Tsai SC, Lu CC, Chen JJ, Shih HC, Chen YH, Lin H, Hwu CM, and Wang PS 1997 Inhibition of bufalin on pituitary and testicular function in rats,Journal of Pharmacology and Experimental Therapy 283. pp.528-532 . (SCI)

Symposium Presentation

Yang MS, Hsu FN, and Lin H* 2008 2008 Changes of survival signalings between androgen-dependent and -independnet status in prostate cancer cells,The 23th Joint Annual Conference of Biochemical Science. Taipei, Taiwan, March 29~30. (Oral Session #44) .
Lee, GS and Lin H*. 2008 2008 Roscovitine inhibits proliferation of prostate cancer cells possibly through Cdk5 inhibition,The 23th Joint Annual Conference of Biochemical Science. Taipei, Taiwan, March 29~30. (Oral Session #8) .
Liu CY, Lin LL, Chiang MC, Lin H*. 2008 2008 The role of EGFR translocation in prostate cancer cells,The 23th Joint Annual Conference of Biochemical Science. Taipei, Taiwan, March 29~30. (Oral Session #6) .
Lin LL, Hsu FN, and Lin H*. 2008 2008 Cdk5 interferes cyclin D1-dependent regulation of androgen receptor,The 23th Joint Annual Conference of Biochemical Science. Taipei, Taiwan, March 29~30.
You SC, Kuo HS, Lin LL, and Lin H*. 2007 2007 All-trans-Retinoic Acid (RA)-induced protein interaction between Cdk5 and p21 CIP1 promote G1 arrest 15th Symposium on Recent Advances in Cellular and Molecular Biology,Kenting, Taiwan, 1-3, February, 2007. (Poster # 80) .
Lin H*, Chen MC, and Wang PS 2007 2007 Nicotine decreases testosterone production and Leydig cell viability through Cdk5 hyperactivation. Program and Abstract of the 40th Annual Meeting of the Society for the Study of Reproduction,San Antonio, USA 21-25, July, 2007. (poster # 414) .
Chiu CY, Peng HC, and Lin H*. 2007 2007 The role of cdk5 in GDNF-induced proliferation of human medullary thyroid carcinoma cells,The 22nd Joint Annual Conference of Biochemical Science. Taipei, Taiwan, March 17~18, 2007. (Oral Session #002) .
Hsu FN, Lin LL, Huang WH, and Lin H* 2007 2007 Cdk5 regulates proliferation of prostate cancer 5\r\ncells through androgen receptor phosphorylation 15th Symposium on Recent Advances in Cellular and Molecular Biology,Kenting, Taiwan, 1-3, February, 2007. (Poster # 74) .
Chen CC and Lin H 2006 2006 The role pf p35/Cdk5 in N-cadherin/beta-catenin-related adhesion in prostate cancer cells,The 21th Joint Annual Conference of Biochemical Science. Taipei, Taiwan, March 18~19. (Poster Session #504) .
Ku CT, Chiu CY, You SC, and Lin H. 2006 2006 Retinoic acid-induced differentiation of prostate cancer cell line, DU145, is through upergulation o The 21th Joint Annual Conference of Biochemical Science. Taipei, Taiwan, March 18~19.
Kuo HS, Chiang MC, Tseng SH, and Lin H. 2006 2006 Relationship between Cdk5/p35 and p53 proteins in retinoic acid-induced differentiation of HeLa cell The 21th Joint Annual Conference of Biochemical Science,Taipei, Taiwan, March 18~19. (Poster Session #294) .
Tseng CF, Hsu FN, and Lin H. 2006 2006 The involvement of Cdk5 and p35 in Her2/ErbB3-dependent androgen receptor signaling pathway,The 21th Joint Annual Conference of Biochemical Science. Taipei, Taiwan, March 18~19. (Oral Session #028) .
Li GS, Tsai SY, and Lin H. 2006 2006 The role of Cdk5/p35 in NGF-induced differentiation of PC12, The 21th Joint Annual Conference of Biochemical Science. Taipei, Taiwan, March 18~19. (Poster Session #313) .
Lin H, Chen MC 2005 2005 The biological functions of cyclin-dependent kinase 5 and p35 protein in androgen production of mous Program and Abstract of the 38th Annual Meeting of the Society for the Study of Reproduction,Quebec, Cananda. 24-27, July, 2005 (Program # 751) .
Lin H. 2005 2005 The roles of cdk5 and p35 protein in androgen production of mouse leydig cells,The 20th Joint Annual Conference of Biochemical Science.
Lin H, Chen MC, Juang JL, and Wang PS 2004 2004 A possible curative effect of digoxin on prostate cancer,Twelfth International Congress of Endocrinology, Lisbon, Portugal. August 31~September 4 (Oral Session # 16) .

Research Project

Cdk5蛋白對於多囊性卵巢疾病之扮演角色的探討 (WR2)